Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study

Shin, Ji-Hee; Ahn, Yong Ju; Chung, Won‐Hyong; Lim, Mi Young; Hong, Seungpyo; Kim, Joong‐Hark; Park, Mi Houn

doi:10.3389/fnut.2021.743620

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…Their enhanced ability to ferment and metabolize carbohydrates and lipids may link to the development of obesity [23,24]. Dietary compounds, such as fiber and fat, are one of the important modulators of gut microbiome composition [25]. Dietary fiber is a functional food component that can greatly impact the composition, diversity, and abundance of bacteria in the microbiome.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Effects of Weight-Loss Meal Replacement Programs with Various Macronutrient Distributions on Gut Microbiome and Metabolic Parameters: A Pilot Study

Song,

Shon,

Yang

et al. 2023

Nutrients

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It has emerged the gut microbiome is crucially linked to metabolic health and obesity. Macronutrient distribution has been discussed as a key parameter in weight-loss programs, but little is known about its impact on the gut microbiome. We investigated the effects of weight-loss meal replacement programs with different macronutrient ratios on the gut microbiota and metabolic parameters in subjects with overweight and obesity. Three low-calorie meal replacement programs with different ratios of carbohydrates, proteins, and lipids were designed: a balanced diet (Group B, 60:15:30), a high-lipid−low-carbohydrate diet (Group F, 35:20:55), and a protein-enriched diet (Group P, 40:25:35). Sixty overweight or obese participants were provided with the meals twice daily for 3 weeks. In all groups, diet intervention resulted in reduced body weight and BMI. The relative abundance of Bacteroidetes and Firmicutes phyla decreased and increased, respectively, which increased the Firmicutes/Bacteroidetes (F/B) ratio in all subjects, particularly in Groups B and P. Alpha- and beta-diversity were augmented at the phylum level in Group P. In conclusion, short-term interventions with weight-loss meal replacement programs increased butyrate-producing bacteria and the F/B ratio. Moreover, the protein-enriched diet significantly increased alpha- and beta-diversity compared to the balanced diet and the high-lipid−low-carbohydrate diet.

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Section: Introductionmentioning

confidence: 99%

Short-Term Effects of Weight-Loss Meal Replacement Programs with Various Macronutrient Distributions on Gut Microbiome and Metabolic Parameters: A Pilot Study

Song,

Shon,

Yang

et al. 2023

Nutrients

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show abstract

Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut microbiome

Whelan,

Alexander,

Gaiani

et al. 2024

Nat Microbiol

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Understanding the bacterial compositional network associations between oral and gut microbiome within healthy Koreans

Jeong

Ahn²,

Mun

et al. 2023

Journal of Oral Microbiology

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Oral microbial ecosystem could influence intestinal diseases, but there have been insufficient studies demonstrating the association of microbial composition between the oral cavity and the intestinal system. Thus, we aimed to investigate the compositional network within the oral microbiome related to gut enterotype from saliva and stool samples collected from 112 healthy Korean subjects. Here, we performed bacterial 16S amplicon sequencing from clinical samples. Then, we determined oral microbiome type related to individual’s gut enterotype for healthy Korean. The co-occurrence analysis was performed to interactivity prediction of microbiome within saliva samples. As a result, it could be classified into two Korean oral microbiome types (KO) and four oral–gut-associated microbiome types (KOGA) according to distribution and significant differences of oral microflora. The co-occurrence analysis showed various bacterial compositional networks linked around Streptococcus and Haemophilus within healthy subjects. The present study was first approach in healthy Koreans to identify the oral microbiome types related to the gut microbiome and investigate their characteristics. Hence, we suggest that our results could be potential healthy control data for identifying differences in microbial composition between healthy people and oral disease patients and studying microbial association with the gut microbial environment (oral–gut microbiome axis).

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Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study

Cited by 3 publications

References 59 publications

Short-Term Effects of Weight-Loss Meal Replacement Programs with Various Macronutrient Distributions on Gut Microbiome and Metabolic Parameters: A Pilot Study

Short-Term Effects of Weight-Loss Meal Replacement Programs with Various Macronutrient Distributions on Gut Microbiome and Metabolic Parameters: A Pilot Study

Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut microbiome

Understanding the bacterial compositional network associations between oral and gut microbiome within healthy Koreans

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