Effect of saffron, black seed, and their main constituents on inflammatory cytokine response (mainly TNF-α) and oxidative stress status: an aspect on pharmacological insights

Vafaeipour, Zeinab; Rahbardar, Mahboobeh Ghasemzadeh; Hosseinzadeh, Hossein

doi:10.1007/s00210-023-02501-w

Cited by 5 publications

(3 citation statements)

References 156 publications

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“…The mechanism of action of saffron in reducing the carbohydrate profile has been studied in many in vivo and in vitro studies [ 123 , 124 , 125 , 126 ]. These carotenoids have been shown to increase insulin sensitivity, improve pancreatic beta cell function, enhance the production and activity of antioxidant enzymes, and decrease oxidative stress indices and inflammation markers such as TNF-alpha [ 123 , 124 , 126 , 127 ]. Another study has suggested that saffron consumption and exercise could improve diabetic parameters through redox-mediated mechanisms and the GLUT4/AMPK pathway to trap glucose uptake [ 125 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis

Garza,

Pérez-Calahorra,

Rodrigo-Carbó

et al. 2024

Nutrients

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Background: The Mediterranean Diet (MedDiet) is the dietary pattern par excellence for managing and preventing metabolic diseases, such as Type 2 Diabetes (T2DM). The MedDiet incorporates spices and aromatic herbs, which are abundant sources of bioactive compounds. The aim of this study was to analyze the effect of all aromatic herbs and spices included in the MedDiet, such as black cumin, clove, parsley, saffron, thyme, ginger, black pepper, rosemary, turmeric, basil, oregano, and cinnamon, on the glycemic profile in T2DM subjects. Methods: PubMed, Web of Science, and Scopus databases were searched for interventional studies investigating the effect of these aromatic herbs and spices on the glycemic profile in T2DM subjects. Results: This systematic review retrieved 6958 studies, of which 77 were included in the qualitative synthesis and 45 were included in the meta-analysis. Our results showed that cinnamon, turmeric, ginger, black cumin, and saffron significantly improved the fasting glucose levels in T2DM subjects. The most significant decreases in fasting glucose were achieved after supplementation with black cumin, followed by cinnamon and ginger, which achieved a decrease of between 27 and 17 mg/dL. Conclusions: Only ginger and black cumin reported a significant improvement in glycated hemoglobin, and only cinnamon and ginger showed a significant decrease in insulin.

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Section: Discussionmentioning

confidence: 99%

Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis

Garza,

Pérez-Calahorra,

Rodrigo-Carbó

et al. 2024

Nutrients

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“…Upon LPS stimulation, TLR4 uses MyD88 junction protein to transmit signals that activate NF-κB and induce inflammatory cytokines 37 , 38 . Recent studies revealed that TLR4/Myd88/NF-κB is a signaling pathway that improves IL-6, TNF-α, and TGF-β production 39 – 41 . The results of this study indicate significantly increased protein expression of key nodes of the TLR4/Myd88/NF-κB pathway in the esophagus of mice modeled for esophageal cancer in situ, and the same changes in protein expression were observed in esophageal cancer cells after LPS treatment in vitro.…”

Section: Discussionmentioning

confidence: 99%

Bacteroidetes promotes esophageal squamous carcinoma invasion and metastasis through LPS-mediated TLR4/Myd88/NF-κB pathway and inflammatory changes

Wu,

Guo,

Zhang

et al. 2024

Sci Rep

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Gut microbiota plays a crucial role in gastrointestinal tumors. Additionally, gut microbes influence the progression of esophageal cancer. However, the major bacterial genera that affect the invasion and metastasis of esophageal cancer remain unknown, and the underlying mechanisms remain unclear. Here, we investigated the gut flora and metabolites of patients with esophageal squamous cell carcinoma and found abundant Bacteroides and increased secretion and entry of the surface antigen lipopolysaccharide (LPS) into the blood, causing inflammatory changes in the body. We confirmed these results in a mouse model of 4NQO-induced esophageal carcinoma in situ and further identified epithelial–mesenchymal transition (EMT) occurrence and TLR4/Myd88/NF-κB pathway activation in mouse esophageal tumors. Additionally, in vitro experiments revealed that LPS from Bacteroides fragile promoted esophageal cancer cell proliferation, migration, and invasion, and induced EMT by activating the TLR4/Myd88/NF-κB pathway. These results reveal that Bacteroides are closely associated with esophageal cancer progression through a higher inflammatory response level and signaling pathway activation that are both common to inflammation and tumors induced by LPS, providing a new biological target for esophageal cancer prevention or treatment.

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“…In traditional Persian medicine, saffron has been recommended as a natural remedy for insomnia and sleep disturbances (Taherzadeh et al, 2020). Recent pharmacological research has demonstrated that saffron stigma possesses several beneficial effects, including anxiolytic (Hosseinzadeh & Noraei, 2009; Pitsikas & Tarantilis, 2020), antinociceptive (Hosseinzadeh & Shariaty, 2007; Hosseinzadeh & Younesi, 2002), anticonvulsant (Hosseinzadeh & Khosravan, 2002), antidepressant (Ghasemi et al, 2015; Hosseinzadeh et al, 2004), neuroprotective (Bedrood et al, 2023) properties that are based on its antioxidant (Hosseinzadeh et al, 2008; Hosseinzadeh et al, 2009; Kiashemshaki et al, 2021), anti‐inflammatory (Vafaeipour et al, 2023), and antiapoptotic (Mohammadzadeh et al, 2022; Rajabian et al, 2023) properties.…”

Section: Herbal Sleep‐inducing Medicinesmentioning

confidence: 99%

Therapeutic potential of hypnotic herbal medicines: A comprehensive review

Ghasemzadeh Rahbardar,

Hosseinzadeh

2024

Phytotherapy Research

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Insomnia affects millions of people worldwide, prompting considerable interest in herbal remedies for its treatment. This review aims to assess the therapeutic potential of such remedies for insomnia by analyzing current scientific evidence. The analysis identified several herbs, including Rosmarinus officinalis, Crocus sativus, Rosa damascena, Curcuma longa, Valeriana officinalis, Lactuca sativa, Portulaca oleracea, Citrus aurantium, Lippia citriodora, and Melissa officinalis, which show promise in improving overall sleep time, reducing sleep latency, and enhancing sleep quality. These plants act on the central nervous system, particularly the serotonergic and gamma‐aminobutyric acid (GABA)ergic systems, promoting sedation and relaxation. However, further research is necessary to fully understand their mechanisms of action, optimal dosages, and treatment protocols. Combining herbal medicines with conventional treatments may offer an effective natural alternative for those seeking medication. Nevertheless, individuals should consult their healthcare provider before using herbal remedies for insomnia. While this review provides evidence supporting their use, additional high‐quality studies are needed to firmly establish their clinical efficacy.

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Effect of saffron, black seed, and their main constituents on inflammatory cytokine response (mainly TNF-α) and oxidative stress status: an aspect on pharmacological insights

Cited by 5 publications

References 156 publications

Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis

Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis

Bacteroidetes promotes esophageal squamous carcinoma invasion and metastasis through LPS-mediated TLR4/Myd88/NF-κB pathway and inflammatory changes

Therapeutic potential of hypnotic herbal medicines: A comprehensive review

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