Effect of salbutamol nebulization in transient tachypnea of newborn

Abstract

Background: Transient tachypnea of newborn (TTN) is a parenchymal lung disease present in neontes usually within 6 hours of life. Signs of TTN usually persist for 12-24 hours in mild disease but can last upto 72 hours in more severe cases. In severe cases of TTN, complications such as pneumothorax, need for extracorporeal membrane oxygenation, and death have been reported. Objective: To study the effect of single dose of salbutamol nebulization in TTN administered at diagnosis and assess its efficacy at 30minutes, 1hour and 4 hours post nebulization and the side effects if any at 4 hours Materials and methods: Study design: Double blind prospective placebo controlled study, one dose of inhaled salbutamol or normal saline solution was administered to 50 newborns each with gestational age of 35 to 41 weeks and diagnosed as TTN according to clinical and radiological features. Setting: Pediatrics Department, Bebe Nanki Mother and Child Care Centre, Government Medical College, Amritsar. Participants:100 newborns. Outcome variables: TTN score, oxygen saturation, respiratory rate and average duration of hospital stay. Results: After one dose of salbutamol nebulization, the TTN score, respiratory rate, oxygen saturation and duration of hospitalization did not decrease significantly when compared with the normal saline group (p value >0.05). No side effects like tachycardia, hypokalemia and hyperglycemia were noted in salbutamol group when compared to normal saline group. Conclusion: Inhaled salbutamol treatment did not show any effect on early resolution of symptoms and early discharge of babies.