Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24

Qu, Hu; Ma, Bo; Yuan, Huiping; Wang, Zhongyang; Guo, Shengjie; Zhang, Jing

doi:10.1016/j.apjtm.2015.06.004

Cited by 14 publications

(10 citation statements)

References 15 publications

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“…Recently, studies have indicated that SAL inhibits cell migration and invasion in a variety of cancer types in vitro (17), in addition to reducing metastasis in vivo (32,33). In the present study, the invasive ability of canine mammary CSCs was decreased following treatment with SAL in vitro; however, whether SAL has inhibits the metastasis of canine mammary tumor cells requires additional study.…”

Section: Discussioncontrasting

confidence: 39%

Salinomycin inhibits canine mammary carcinoma in vitro by targeting cancer stem cells

Zhou

Zhang

et al. 2017

Oncology Letters

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Abstract. Salinomycin (SAL), a polyether ionophore antibiotic, has been demonstrated to selectively kill cancer stem cells (CSCs) in various types of human tumor. The aim of the present study was to investigate the effects of SAL on canine mammary CSCs. CSCs in canine mammary carcinoma cell lines (CMT7364 and CIPp) were identified using a sphere formation assay and flow cytometry. The chemoresistance, invasive potential and expression of stem cell-associated proteins of these spheres was then analyzed. This demonstrated that the spheres exhibited characteristics of CSCs, including a cluster of differentiation (CD)44 + /CD24 -/low phenotype, upregulation of Wnt/β-catenin signaling pathway-associated proteins and chemoresistance. The viability of the spheres was decreased in a concentration-and time-dependent manner following treatment with SAL, and the spheres did not exhibit increased resistance to SAL compared with their parental cells. In addition, exposure to SAL inhibited sphere-formation and invasive potential in canine mammary CSCs in a dose-dependent manner. Furthermore, SAL decreased the CD44 + /CD24 -/low population and downregulated the expression of Wnt/β-catenin signaling-associated proteins (β-catenin, Cyclin D1 and octamer-binding transcription factor 4) in the spheres. In conclusion, the present study demonstrated that SAL is an effective inhibitor of canine mammary CSCs in vitro, indicating that SAL is a promising chemotherapeutic agent for the treatment of canine mammary carcinoma.

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Section: Discussioncontrasting

confidence: 39%

Salinomycin inhibits canine mammary carcinoma in vitro by targeting cancer stem cells

Zhou

Zhang

et al. 2017

Oncology Letters

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“…Furthermore, it suppresses the migration of colorectal, breast, lung and colon cancer cell lines as well the invasion of nasopharyngeal carcinoma and bladder cancer cells in vitro (Kopp et al, 2014;Wu et al, 2014;Qu et al, 2015;Klose et al, 2016). Consistently, in vivo studies proved that salinomycin may reduce metastasis formation in mammary tumor mouse model, bladder tumor rat model and intravenous mouse tumor model (Gupta et al, 2009;Kopp et al, 2014;Qu et al, 2015). Importantly, salinomycin is able to suppress the late stages of autophagy contributing to the ROS generation and mitochondria dysfunction (Klose et al, 2019).…”

Section: Therapeutic Targeting Metastasismentioning

confidence: 77%

Mitochondrial Involvement in Migration, Invasion and Metastasis

Denisenko

Горбунова

Zhivotovsky

2019

Front. Cell Dev. Biol.

103

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Mitochondria in addition to be a main cellular power station, are involved in the regulation of many physiological processes, such as generation of reactive oxygen species, metabolite production and the maintenance of the intracellular Ca 2+ homeostasis. Almost 100 years ago Otto Warburg presented evidence for the role of mitochondria in the development of cancer. During the past 20 years mitochondrial involvement in programmed cell death regulation has been clarified. Moreover, it has been shown that mitochondria may act as a switchboard between various cell death modalities. Recently, accumulated data have pointed to the role of mitochondria in the metastatic dissemination of cancer cells. Here we summarize the modern knowledge concerning the contribution of mitochondria to the invasion and dissemination of tumor cells and the possible mechanisms behind that and attempts to target metastatic cancers involving mitochondria.

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“…CSCs are believed to play an important role in metastasis, the deadliest cancer progression. Multiple researchers have shown salinomycin decreases CSC invasiveness and migration (44)(45)(46)(47). This physiologic change is associated with the FAK-ERK1/2 signaling pathway in liver CSCs (44) and the abolition of STAT3 and STAT1 interactions in colorectal CSCs (45).…”

Section: Salinomycin's Effect On Csc Stemnessmentioning

confidence: 98%

Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review)

Magrath

Kim

2017

International Journal of Oncology

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Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain tumor. Despite treatment with surgery, radiotherapy, and chemotherapy with the drug temozolomide, the expected survival after diagnosis remains low. The median survival is only 14.6 months and the two-year survival is a mere 30%. One reason for this is the heterogeneity of GBM including the presence of glioblastoma cancer stem cells (GSCs). GSCs are a subset of cells with the unique ability to proliferate, differentiate, and create tumors. GSCs are resistant to chemotherapy and radiation and thought to play an important role in recurrence. In order to effectively treat GBM, a drug must be identified that can kill GSCs. The ionophore salinomycin has been shown to kill cancer stem cells and is therefore a promising future treatment for GBM. This study focuses on salinomycin's potential to treat GBM including its ability to reduce the CSC population, its toxicity to normal brain cells, its mechanism of action, and its potential for combination treatment.

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Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24

Abstract: Salinomycin can suppress the metastasis and invasion of bladder cancer cells, of which the mechanism is probably associated with the inhibition of EMT of tumor cells.

Cited by 14 publications

References 15 publications

Salinomycin inhibits canine mammary carcinoma in vitro by targeting cancer stem cells

Salinomycin inhibits canine mammary carcinoma in vitro by targeting cancer stem cells

Mitochondrial Involvement in Migration, Invasion and Metastasis

Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review)

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