Effect of Salvia leriifolia leaf extract on morphine dependence in mice

Hosseinzadeh, Hossein; Lary, Parisa

doi:10.1002/1099-1573(200008)14:5<384::aid-ptr641>3.0.co;2-f

Cited by 33 publications

(9 citation statements)

References 18 publications

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“…On day 4, a single dose of morphine (50 mg/kg) was injected 2 h before naloxone treatment. In fact each mouse received 10 doses of morphine (Zarrindast et al, 1995;Hosseinzadeh and Lary, 2000).…”

Section: Morphine Dependencementioning

confidence: 99%

Effect of crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice

Hosseinzadeh¹,

Jahanian²

2009

Phytotherapy Research

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Crocus sativus L. has been shown to interact with the opioid system. Thus, the effects of aqueous and ethanolic extracts of stigma and its constituents were evaluated on morphine-withdrawal syndrome in mice. Dependence was induced using subcutaneous (s.c.) injections of morphine for 3 days. On day 4, morphine was injected 0.5 h prior the interaperitoneal (i.p.) injections of the extracts, crocin, safranal, clonidine (0.3 mg/kg) or normal saline. Naloxone was injected (5 mg/kg i.p.) 2 h after the final dose of morphine and the number of episodes of jumping during 30 mm was considered as the intensity of the withdrawal syndrome. Clonidine, the aqueous and ethanolic extracts of saffron reduced the jumping activity. Safranal was injected (s.c.) 30 mm prior and 1 and 2 h after the injection of morphine. It potentiated some signs of withdrawal syndrome. The aqueous extract decreased the movement in all of the doses (80, 160, 320 mg/kg) and the ethanolic extract decreased it in the dose of 800 mg/kg in open field test. But crocin and the dose of 400 mg/kg ethanolic extract showed no effect on activity in this test. It is concluded that the extracts and crocin may have interaction with the opioid system to reduce withdrawal syndrome.

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Section: Morphine Dependencementioning

confidence: 99%

Effect of crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice

Hosseinzadeh¹,

Jahanian²

2009

Phytotherapy Research

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“…The activities of flavonoids may be responsible for the alleviation of withdrawal signs in morphine-dependent mice. However, previous studies have reported that the mechanisms of some Lamiaceae plants such as Rosmarinus officinalis (17), Nepeta glomerulosa (18), Salvia leriifolia (19) and Marrubium vulgare (20) in reducing morphine withdrawal signs are mainly through the reduction of motor activity, as well as coordination and interaction with opioid receptors.…”

Section: Discussionmentioning

confidence: 99%

Thymus Daenensis Extract and Essential Oils Effects on Morphine Withdrawal Signs in Mice

Khodayar

Taherzadeh

Siahpoosh

et al. 2014

Jundishapur J Nat Pharm Prod

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Background: Thymus species are well known medicinal plants which the previous studies suggested the involvement of the opioid system in them. Objectives: This study aimed to investigate the effects of methanolic extract and essential oil of aerial parts of Thymus daenensis (TD), an endemic aromatic medicinal plant of Iran, on morphine withdrawal syndrome in mice. Materials and Methods: Experiments were performed in two groups of five, each group treated with extracts or essential oils of TD. Dependency was induced by subcutaneous injection of morphine for three consecutive days. On the fourth day, the last dose of morphine was injected two hours prior to intraperitoneal injection of naloxone while the extract or essential oil of TD was administered 30 minutes before naloxone. A period of 20 minutes after naloxone injection was considered the critical period of the withdrawal syndrome. The number of jumps, standing, leaning, and the weight of stools were recorded as withdrawal signs. Results: The 200 mg/kg and 400 mg/kg doses of extract and all doses of essential oil decreased significantly the number of jumps, standing, leaning and the weight of stool. Administration of 100 mg/kg of extract only decreased the weight of stool and had no effect on the other factors. Conclusions: Extract and essential oil of TD attenuates morphine withdrawal behaviors in mice and may be useful in alleviating the signs and symptoms of opiate withdrawal syndrome in human.

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“…0.5 h after the final dose of morphine. Withdrawal syndrome was assessed by counting the number of jumping episodes for 60 min after naloxone injection [1,[6][7][8].…”

Section: Drug and Fractions Treatmentmentioning

confidence: 99%

Effects of Root Extracts of Withania Coagulans on Withdrawal Syndrome in Albino Mice

Karami¹

2012

TOPHARMCJ

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Abstract:It is known that repeated use of opioid drugs causes physical dependence and tolerance. Dependance can be measured by evocation of abstinence sign by abrupt drug withdrawal or administration of a narcotic antagonist or both. After induction of dependence by morphine, mice are divided in to seven groups using distilled water as the control group. The other six groups were injected by different concentrations of plant root extract. To assess morphine withdrawal, mice injected naloxone (5 mg/kg) i.p. on the day 4 th after three consecutive days of morphine injection, withdrawal syndrome was assessed by placing each mouse in a 30 cm high glass box and recording the incidence of escape jumps for 60 mins. Animal receiving acute treatment with morphine displayed dependence. The Albino mice treated with alcoholic, chloroform and ethyl acetate extracts of Withania coagulans roots could decrease incidence of escape jumps in number or decrease development of morphine dependence and other hand addiction following naloxone administration.

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Effect of Salvia leriifolia leaf extract on morphine dependence in mice

Cited by 33 publications

References 18 publications

Effect of crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice

Effect of crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice

Thymus Daenensis Extract and Essential Oils Effects on Morphine Withdrawal Signs in Mice

Effects of Root Extracts of Withania Coagulans on Withdrawal Syndrome in Albino Mice

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