Effect of samarium oxide nanoparticles on virulence factors and motility of multi-drug resistant Pseudomonas aeruginosa

Zahmatkesh, Hossein; Mirpour, Mirsasan; Zamani, Hojjatolah; Rasti, Behnam; Rahmani, Fatemeh; Padasht, Nasim

doi:10.1007/s11274-022-03384-4

Cited by 17 publications

(7 citation statements)

References 76 publications

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“…Our data indicated the effect of paeoniflorin in inhibiting both bacterial biofilm formation and bacterial motility, which suggested that the paeoniflorin can play its function at different developmental stages for bacterial pathogens. Effect of certain compounds in inhibiting both bacterial biofilm formation and bacterial motility has also been frequently found in other published reports ( Ye et al, 2022 ; Zahmatkesh et al, 2022 ).…”

Section: Discussionsupporting

confidence: 71%

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Treatment with paeoniflorin increases lifespan of Pseudomonas aeruginosa infected Caenorhabditis elegans by inhibiting bacterial accumulation in intestinal lumen and biofilm formation

et al. 2023

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Paeoniflorin is one of the important components in Paeoniaceae plants. In this study, we used Caenorhabditis elegans as a model host and Pseudomonas aeruginosa as a bacterial pathogen to investigate the possible role of paeoniflorin treatment against P. aeruginosa infection in the host and the underlying mechanisms. Posttreatment with 1.25–10 mg/L paeoniflorin could significantly increase the lifespan of P. aeruginosa infected nematodes. After the infection, the P. aeruginosa colony-forming unit (CFU) and P. aeruginosa accumulation in intestinal lumen were also obviously reduced by 1.25–10 mg/L paeoniflorin treatment. The beneficial effects of paeoniflorin treatment in increasing lifespan in P. aeruginosa infected nematodes and in reducing P. aeruginosa accumulation in intestinal lumen could be inhibited by RNAi of pmk-1, egl-1, and bar-1. In addition, paeoniflorin treatment suppressed the inhibition in expressions of pmk-1, egl-1, and bar-1 caused by P. aeruginosa infection in nematodes, suggesting that paeoniflorin could increase lifespan of P. aeruginosa infected nematode by activating PMK-1, EGL-1, and BAR-1. Moreover, although treatment with 1.25–10 mg/L paeoniflorin did not show obvious anti-P. aeruginosa activity, the P. aeruginosa biofilm formation and expressions of related virulence genes (pelA, pelB, phzA, lasB, lasR, rhlA, and rhlC) were significantly inhibited by paeoniflorin treatment. Treatment with 1.25–10 mg/L paeoniflorin could further decrease the levels of related virulence factors of pyocyanin, elastase, and rhamnolipid. In addition, 2.5–10 mg/L paeoniflorin treatment could inhibit the swimming, swarming, and twitching motility of P. aeruginosa, and treatment with 2.5–10 mg/L paeoniflorin reduced the cyclic-di-GMP (c-di-GMP) level. Therefore, paeoniflorin treatment has the potential to extend lifespan of P. aeruginosa infected hosts by reducing bacterial accumulation in intestinal lumen and inhibiting bacterial biofilm formation.

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Section: Discussionsupporting

confidence: 71%

“…The method for twitching motility was performed as described ( Zahmatkesh et al, 2022 ). Twitching agar plates containing 1.5% agar with the addition of paeoniflorin in Luria Broth were prepared.…”

Section: Methodsmentioning

confidence: 99%

Treatment with paeoniflorin increases lifespan of Pseudomonas aeruginosa infected Caenorhabditis elegans by inhibiting bacterial accumulation in intestinal lumen and biofilm formation

et al. 2023

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“…All the other elements originated in the propelled solution interacting with the air plasma, basically nitrogen/oxygen. The EDS spectrum for the samarium coating obtained by APPJ shows the same peaks as similar systems obtained by other methods 67,68 . Therefore, the APPJ method could be an option for the deposition of samarium species.…”

Section: Samarium Compound Layers By Appjsupporting

confidence: 74%

Study of the anticorrosive behavior of samarium as a corrosion inhibitor in multilayer systems for aluminum alloy

Mendez

Rojas

Bueno

et al. 2023

Sci Rep

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This study shows a multilayer system based on samarium compounds as a corrosion inhibitor and a continuous SiO2 layer by atmospheric pressure plasma jet (APPJ) as a protective barrier for aluminim alloy AA3003. One of the main advantages of this new coating is that it does not require vacuum chambers, which makes it easy to incorporate into production lines for automotive and aeronautical components, etc. The deposit of samarium corrosion inhibitor was carried out by two methods for comparison, the immersion method and a novel method to deposit corrosion inhibitor by APPJ. The multilayer system generated was homogeneous, continuous, adherent, and dense. The electrochemical behavior shows that the samarium compound was completely oxidized on coatings by the immersion method and favors corrosion. The APPJ deposition method shows a protective behavior against corrosion by both samarium compounds and silica depositions. XPS analyses show that the amount of Sm(OH)3 increases by the APPJ method compared with the immersion method since the spectrum of O1s is mainly controlled by OH. It was determined that the best processing times for the electrochemical study of the multilayer system were 40 min for the immersion method and 30 s for the APPJ method for the layer of corrosion inhibitor. In the case of the SiO2 barrier layer by APPJ, the best time was 60 s of exposure to the plasma jet and this coating could reduce the corrosion of AA3003 by 31.42%.

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“…Adenosine triphosphate (ATP) release may be inhibited when reactive oxygen species (ROS) are produced more quickly as a result of the generation of free ions. The intracellular and extracellular components of the membrane may separate as a result of denaturation of the microbial cell membrane, which also results in cell lysis [ 58 , 59 ]. In this work, Ag@Sm 2 O 3 -onion has potent antimicrobial activity that may be attributed to the nanoparticles' attachment to microbial surfaces, cell membrane rupture, modification of the respiration chain, and other permeability-dependent activities, and ultimately destruction of microbial significant proteins.…”

Section: Resultsmentioning

confidence: 99%

Phytosynthesis via wasted onion peel extract of samarium oxide/silver core/shell nanoparticles for excellent inhibition of microbes

Alshahrani,

Alqarni,

Alghamdi

et al. 2024

Heliyon

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Effect of samarium oxide nanoparticles on virulence factors and motility of multi-drug resistant Pseudomonas aeruginosa

Cited by 17 publications

References 76 publications

Treatment with paeoniflorin increases lifespan of Pseudomonas aeruginosa infected Caenorhabditis elegans by inhibiting bacterial accumulation in intestinal lumen and biofilm formation

Treatment with paeoniflorin increases lifespan of Pseudomonas aeruginosa infected Caenorhabditis elegans by inhibiting bacterial accumulation in intestinal lumen and biofilm formation

Study of the anticorrosive behavior of samarium as a corrosion inhibitor in multilayer systems for aluminum alloy

Phytosynthesis via wasted onion peel extract of samarium oxide/silver core/shell nanoparticles for excellent inhibition of microbes

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