Effect of sarcopenia on clinical outcomes following digestive carcinoma surgery: a meta-analysis

Hua, Hongxia; Xu, Xinyi; Tang, Yu; Ren, Ziqi; Xu, Qi; Chen, Li

doi:10.1007/s00520-019-04767-4

Cited by 37 publications

(16 citation statements)

References 46 publications

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“…Then, we chose the newest meta‐analysis with the largest number of studies. Finally, 54 health‐related outcomes extracted from 30 meta‐analyses 10,22‐50 were reported in this umbrella review. These 54 outcomes were mainly about prognostic outcomes of tumor, postoperative outcomes, age‐related outcomes, metabolic outcomes, and other outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…Totally 16 postoperative outcomes of tumors were reported 10,25,33‐35 . For esophageal cancer, patients with sarcopenia had significantly higher risk of overall postoperative complications and pulmonary complications, while no association was found with anastomotic leakage.…”

Section: Resultsmentioning

confidence: 99%

“…Totally 16 postoperative outcomes of tumors were reported. 10,25,[33][34][35] For esophageal cancer, patients with sarcopenia had significantly higher risk of overall postoperative complications and pulmonary complications, while no association was found with anastomotic leakage. In patients of digestive cancer, sarcopenia significantly increased the rate of readmission (RR, 2.53; 95% CI 1.66-3.85) and prolonged the length of hospitalization (RR, 4.61; 95% CI 1.84-7.39).…”

Section: Postoperative Outcomesmentioning

confidence: 97%

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Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies

et al. 2020

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Objective The purpose of this umbrella review was to assess the associations between sarcopenia and adverse health‐related outcomes. Design An umbrella review of meta‐analyses of observational studies. Setting and Participants Patients with sarcopenia and controls without sarcopenia were included. Measures The PubMed, Web of Science and Embase were searched for relevant systematic review and meta‐analysis. AMSTAR and GRADE system were used for methodological quality and evidence quality assessments, respectively. Results Totally 54 outcomes extracted from 30 meta‐analyses were analyzed. Twenty out of 21 prognostic outcomes indicated that sarcopenia was significantly associated with poorer prognosis of gastric cancer, hepatocellular cancer, urothelial cancer, head and neck cancer, hematological malignancy, pancreatic cancer, breast cancer, colorectal cancer, lung cancer, esophageal cancer, and ovarian cancer. Besides, 10 out of 16 postoperative outcomes suggested that sarcopenia significantly increased the risk of multiple postoperative complications and prolonged the length of hospitalization of patients with digestive cancer. In age‐related outcomes, sarcopenia significantly increased the risk of dysphagia, cognitive impairment, fractures, falls, hospitalization, and all‐cause mortality of elderly populations. Moreover, sarcopenia was also associated with higher level of albuminuria, risk of depression, and several metabolic diseases. Conclusions and Implications Sarcopenia significantly affected a wide range of adverse health‐related outcomes, particularly in patients of tumor and elderly populations. Because evidences of most outcomes were rated as “low” and “very low,” more prospective cohort studies are required in the future.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Postoperative Outcomesmentioning

confidence: 97%

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Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies

et al. 2020

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“…In the present study, almost one‐third of patients were unable to eat solid foods, which might indicate a rather long period of patient delay. Severe malnourishment is a risk factor for complications in any type of surgery, and major operations such as oesophageal resections and total gastrectomy are no exception (Hua et al, ; Sierzega, Chrzan, Wiktorowicz, Kolodziejczyk, & Richter, ). Notably, the oncological and/or surgical treatment was effective in reducing dysphagia and at the one‐month follow‐up 90% of the patients tolerated solids.…”

Section: Discussionmentioning

confidence: 99%

Patient‐reported experience and outcome measures during treatment for gastroesophageal cancer

et al. 2019

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Objective Gastroesophageal cancer has high mortality, and continuous assessment of patient‐reported data is salient for optimisation of supportive care. We aimed to evaluate our multidisciplinary concept with respect to patient‐reported variables. Methods At diagnosis and later during the treatment, three areas of patient‐reported measures were evaluated: the given information and care, fatigue (Multidimensional Fatigue Inventory [MFI‐20]), dysphagia (Ogilvie dysphagia score) and weight loss. Results Of 130 outpatients, planned for a surgical procedure and given a contact nurse (CN), 106 responded. During treatment, 81% of the patients were satisfied with their CN. The given information was considered very good or good by >90% and easily understood. Half of the patients reported need for supportive care, which was rated good by 85%. All dimensions of the MFI‐20 test, except mental fatigue, worsened during the treatment period. At diagnosis, 61% of the patients experienced eating problems, leading to 7% weight loss. Although dysphagia improved, weight loss reached 13% at the end of treatment. Conclusion A multidisciplinary concept can be of value in giving appropriate and understandable information, leading to high satisfaction with the provided care. However, as fatigue and weight loss increased during the treatment period, patients need structured multidisciplinary support.

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“…and is associated with an increase in morbidity (in particular, anastomotic and infectious complications), mortality and length of hospital stay [38]. The perioperative nutritional management strategy must be defined as soon as the consultation with the surgeon or anesthesiologist [Table 6] [37,39].…”

Section: Literature Datamentioning

confidence: 99%

Nutrition and physical activity: French intergroup clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC, SFP-APA, SFNCM, AFSOS)

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et al. 2020

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This document is a summary of the French intergroup guidelines regarding the nutrition and physical activity (PA) management in digestive oncology. This collaborative work was produced under the auspices of all French medical and surgical societies involved in digestive oncology, nutrition and supportive care. It is based on published guidelines, recent literature review and expert opinions. Recommendations are graded according to the level of evidence. Malnutrition affects more than half of patients with digestive cancers and is often underdiagnosed. It has multiple negative consequences on survival, quality of life and risk of treatment complications. Consequently, in addition to anticancer treatments, supportive care including nutritional support and PA plays a central role in the management of digestive cancers. It is crucial to detect malnutrition (diagnostic criteria updated in 2019) early, to prevent it and to act against it at all stages of the cancer and at all times of the care pathway. In this context, we proposed recommendations for the evaluation and management in nutrition and PA in digestive oncology for each stage of the disease (perioperative setting, during radiation therapy, during systemic treatments, at the palliative phase, after cancer). Guidelines for nutrition and PA management aim at increasing awareness about malnutrition in oncology. They are continuously evolving and need to be regularly updated.

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Effect of sarcopenia on clinical outcomes following digestive carcinoma surgery: a meta-analysis

Cited by 37 publications

References 46 publications

Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies

Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies

Patient‐reported experience and outcome measures during treatment for gastroesophageal cancer

Nutrition and physical activity: French intergroup clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC, SFP-APA, SFNCM, AFSOS)

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