Effect of sarcopenic obesity on deterioration of physical function in the elderly

Kong, Hyun Ho; Won, Chang Won; Kim, Won

doi:10.1016/j.archger.2020.104065

Cited by 26 publications

(35 citation statements)

References 36 publications

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“…The prevalence of SO has been reported to be higher in patients with chronic diseases such as hypertension, diabetes, abnormal lipid metabolism. [18][19][20][21] The results of this study also indicate that the participants in the SO group were older than the those in the non-SO group, suggesting that increasing age may be a risk factor for the occurrence of SO. 22,23 The participants in the SO group were shorter; had faster heart rate; heavier weight; lower WC, BMI, TG, TC, LDL-C, and higher HDL-C; and lower education level than those in the non-SO group.…”

Section: Discussionsupporting

confidence: 53%

The Association Between Sarcopenic Obesity and Hypertension, Diabetes, and Abnormal Lipid Metabolism in Chinese Adults

Yin¹,

Zhang²,

Wang³

et al. 2021

DMSO

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Objective Sarcopenic obesity is associated with several negative health outcomes. However, there are only a few studies on the relationship between SO and metabolic diseases such as diabetes, hypertension, and abnormal lipid metabolism in Chinese adults. The aim of this work was to evaluate the association between SO and hypertension, diabetes, and abnormal lipid metabolism in Chinese adults, and explore the prediction of SO using relevant anthropometric indicators. Materials and Methods All participants underwent a questionnaire interview for the collection of demographic data. Thereafter, they underwent physical examination for the measurement of anthropometric variables, which was performed using bioelectrical impedance analysis. Biochemical measurements were determined according to standard laboratory procedures used for the evaluation of blood parameters. Results We included 14,926 patients aged 35–74 years old. The mean age of the participants was 56.75 ± 9.76 years old, and 39.80% of them were male. The mean body mass index (BMI) was 24.94 ± 3.40 kg/m 2 , and the overall prevalence of SO was 65.1%. The results showed that shorter people; people with faster heart rate; heavier weight; lower waist circumference (WC), BMI, triglyceride level, total cholesterol, and low-density lipoprotein cholesterol levels; and higher high-density lipoprotein cholesterol level are at risk for SO. Conclusion The prevalence of SO is high (65.1%) in Chinese adults aged 35–74 years old. The occurrence of SO is related to hypertension, diabetes, and abnormal lipid metabolism. BMI, WC, and waist-hip ratio may be predictive indicators of SO. The incidence of SO may be reduced by timely intervention and health education for persons at risk of the condition.

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Section: Discussionsupporting

confidence: 53%

The Association Between Sarcopenic Obesity and Hypertension, Diabetes, and Abnormal Lipid Metabolism in Chinese Adults

Yin¹,

Zhang²,

Wang³

et al. 2021

DMSO

View full text Add to dashboard Cite

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“…We also evaluated more performance-based physical function parameters (i.e., SCT-ascent, SCT-descent, TUG) and investigated gait speed more objectively through gait analysis. Also, in agreement with our study, in a study of knee OA by Manoy et al 35 and a study of Korean elderly by Kong et al, 16 the physical performance of patients with obesity with low muscle mass was significantly lower than that of other groups.…”

Section: Discussionsupporting

confidence: 93%

“…In a study that recruited Korean community-dwelling elderly patients, prevalence was 3.8% in males and 6.7% in females. 16 In the study of Godziuk et al 34 in which knee OA patients were recruited, 6.7% of males and 11.3% of females had SO, while Manoy et al 35 reported a prevelance of 15.2% in female knee OA patients; these levels of prevalence are similar to our study in male, but only 1.9% of females had SO. There are differences between studies due to unclear criteria by which SO is diagnosed.…”

Section: Discussionsupporting

confidence: 86%

“…In elderly patients, SO is associated with decreased physical performance, including decreased walking speed, walking limitations, and difficulties climbing stairs. 15 , 16 SO is also related with poorer QOL, longer hospital stay, and higher mortality than those with obesity or sarcopenia alone in community-dwelling elderly patients. 14 , 17 , 18 In patients with both obesity and muscle weakness, a delay in recovery, such as decreased physical function and extended hospital stay, was found after total hip arthroplasty.…”

Section: Introductionmentioning

confidence: 99%

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Associations Between Obesity With Low Muscle Mass and Physical Function in Patients With End-Stage Knee Osteoarthritis

Kim

Lee

Kim

et al. 2021

Geriatr Orthop Surg Rehabil

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Objective: To investigate the prevalence of obesity with low muscle mass and its impact on physical function, quality of life (QOL) and pain in patients with end-stage knee osteoarthritis over 65 years old. Methods: In this cross-sectional study, we assessed a total of 562 patients. After separating the group into males and females, we divided patients into 4 further groups: normal BMI with normal muscle mass, obesity with normal muscle mass, normal BMI with low muscle mass and obesity with low muscle mass. All patients completed stair climbing test (SCT), 6-minute walk test, timed up and go test (TUG), instrumental gait analysis, Western Ontario McMaster Universities Osteoarthritis Index, VAS, and EuroQOL 5 dimensions questionnaire. Results: Obesity with low muscle mass was diagnosed in 6 males subjects (7.8%) and 9 female subjects (1.9%). Patients with obesity and low muscle mass performed the SCT-ascent and descent significantly slower than other body composition groups in both males and females. TUG in males and gait speed in females were also significantly slower in the obesity with low muscle mass group. Stepwise multiple linear regression analysis revealed that in males, obesity with low muscle mass was significantly predictive of SCT ascent (β = 0.409, p < 0.001), SCT-descent (β = 0.405, p < 0.001), and TUG (β = 0.283, p = 0.009), and in females, obesity with low muscle mass was significantly predictive of SCT-ascent (β = 0.231, p < 0.001), SCT-descent (β = 0.183, p < 0.001), and gait speed (β=-0.129, p = 0.004). Conclusions: This study confirms that the combination of obesity and low muscle mass is associated with impaired physical function in patients with end-stage knee osteoarthritis.

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“…Thus, as the sex hormone of each sex decreases with age, males show higher SKM loss rates than females as testosterone levels decrease. Because the decrease in SKM mass may increase the risk of deterioration of physical function [ 22 ], falls and fractures [ 23 ], and decreased QOL [ 24 ] when long-term pancreatic cancer survivors become older, male pancreatic cancer survivors should pay more attention to the decrease in SKM mass after pancreatic cancer surgery than females.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes

Kong

Kim

et al. 2021

JCM

Self Cite

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Previous studies on changes in body composition of pancreatic cancer patients have only focused on short-term survivors. We studied longitudinal body composition changes and factors affecting them in long-term survivors by analyzing many abdominal computed tomography images using artificial intelligence technology. Of 302 patients who survived for >36 months after surgery were analyzed. Multivariate logistic regression analysis for factors affecting body composition changes and repeated-measures analysis of variance to observe differences in the course of change according to each factor were performed. In logistic analysis, preoperative sarcopenia and recurrence were the main factors influencing body composition changes at 1 and 3 years after surgery, respectively. In changes of longitudinal body composition, the decrease in body composition was the greatest at 3–6 months postoperatively, and the preoperative status did not recover even 3 years after surgery. Especially, males showed a greater reduction in skeletal muscle (SKM) after surgery than females (p < 0.01). In addition, SKM (p < 0.001) and subcutaneous adipose tissue (p < 0.05) mass rapidly decreased in case of recurrence. In conclusion, long-term survivors of pancreatic cancer did not recover their preoperative body composition status, and preoperative sarcopenia and recurrence influenced body composition changes.

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Effect of sarcopenic obesity on deterioration of physical function in the elderly

Cited by 26 publications

References 36 publications

The Association Between Sarcopenic Obesity and Hypertension, Diabetes, and Abnormal Lipid Metabolism in Chinese Adults

The Association Between Sarcopenic Obesity and Hypertension, Diabetes, and Abnormal Lipid Metabolism in Chinese Adults

Associations Between Obesity With Low Muscle Mass and Physical Function in Patients With End-Stage Knee Osteoarthritis

Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes

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