Effect of Sargassum Ilicifolium on Ovogenesis in Pcos Induced Rats

Anbu, J.; Krishnan, S. Rama Gokula; Shivalingappa, Santhosh Kumar; Reddy, Ramya P. S.; Nandihalli, Vani B

doi:10.22159/ajpcr.2016.v9i6.13837

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…The rats were then observed daily with visual method until the signs of the irregular estrous cycle appeared. In PCOS condition the level of testosterone was increased due to which incidence of estrous phase or its duration was very less and the rats were shown persistent di-estrous phase (Anbu et al, 2016). To confirm the PCOS, the vaginal smear test was performed at the start of the 6 th week of estradiol injection (Ghafurniyan et al, 2015).…”

Section: Polycystic Inductionmentioning

confidence: 99%

“…Polycystic ovarian syndrome (PCOS) is the emerging infertility disease now a days but its severity varies in different societies due to their eating behavior and living style (Anbu et al, 2016). The PCOS is a complex metabolic and endocrinal disorder that affects both animals and women in their reproductive phases and increases the risk of reproductive abnormalities.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic potential of hydrolysable tannin on weight management oxidative stress and reproductive health in polycystic rats

et al. 2022

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Phytonutrients get attention now days due to their wide application and their tendency to improve the productive and reproductive performance in humans. Hydrolysable tannin (HT) is one of these bionutrients. The present study was aimed to investigate the therapeutic effect of HT on the induced polycystic ovarian syndrome (PCOS) in rats. Forty-five adult female rats with 4 to 5 days regular estrous cycle were selected. The PCOS was induced by a single intramuscular injection of Estradiol Valerate 4 mg/rat/kg. The rats were offered 0.5, 1, 1.5 and 2% of HT/kg body weight through oral gavage for two months. The results had shown a reduction (p<0.05) in average feed intake, body weight and weight gain, total oxidative stress and nutrient digestibility in PCOS rats. Similar reduction trend (p<0.05) in serum luteinizing hormone and insulin was observed; while serum follicular stimulating hormone, serum prolactin and total antioxidant capacity were improved (p<0.05). The ovarian histopathology showed no signs of reduction in cystic follicles while no improvement was observed in healthy follicles. The study concluded that the treatment with 1.5% level of HT had shown the best therapeutic potential for weight management, reduction of oxidative stress and improvement in reproductive health of PCOS rats.

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Section: Polycystic Inductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of hydrolysable tannin on weight management oxidative stress and reproductive health in polycystic rats

et al. 2022

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The effect of dapsone in testosterone enanthate-induced polycystic ovary syndrome in rat

Shirooie

Khaledi

Dehpour

et al. 2021

The Journal of Steroid Biochemistry and Molecular Biology

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Agaricus Subrufescens ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with Letrozole induced polycystic ovarian syndrome

Bukke,

Pathange,

Karumanchi

et al. 2023

J Ovarian Res

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Objective The objective of this study is to investigate the effects of an ethanolic extract derived from Agaricus subrufescens on rat models exhibiting Polycystic Ovarian Syndrome (PCOS) induced by Letrozole. Methods A total of thirty female Wistar rats were divided into five groups, each consisting of six rats. The negative control group was administered a volume of 1 mL of a 0.5% solution of carboxy methylcellulose (CMC). Letrozole (1 mg/kg) was administered to additional groups for a duration of 21 days in order to induce polycystic ovary syndrome (PCOS). Animals designated as positive controls were euthanized on the 22nd day. Both the test group and the standard group were subjected to treatment from the 22nd day to the 36th day. The experimental group was administered ethanolic extract of Agaricus subrufescens at doses of 200 mg/kg and 400 mg/kg p.o, while the control group received clomiphene citrate at a dose of 1 mg/kg. The study observed various physiological markers in individuals with polycystic ovarian disease, including estimated blood glucose levels, total cholesterol levels, triglyceride levels, and hormonal fluctuations such as increased testosterone and estrogen levels, as well as decreased progesterone levels. The presence of menstrual irregularities was confirmed through the examination of vaginal smears and histopathological changes in the ovaries. Results The consumption of Agaricus subrufescens was found to have a significant impact on various physiological parameters, including blood glucose levels, testosterone levels, anovulation, and menstrual irregularity. All therapeutic interventions significantly normalized the levels of serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT). The rats with polycystic ovary syndrome (PCOS) that were induced by Letrozole exhibited increased levels of urea and creatinine. The findings of this study indicate that the administration of Agaricus subrufescens therapy has a protective effect on renal function, as evidenced by a reduction in serum levels of urea and creatinine. In rats with polycystic ovary syndrome (PCOS) induced by Letrozole, the inhibition of hepatic synthesis, promotion of ovarian follicle immaturity, and elevation of androgen secretions result in an increase in the weight of the liver and ovaries. The weight of endocrine organs exhibited a decrease across all treatment groups. The histopathological examination of PCOS specimens revealed an increased presence of cysts and theca lutein cells. The group of rats with polycystic ovary syndrome (PCOS) that did not receive treatment exhibited a higher number of cysts compared to the groups that received treatment. Conclusion This study demonstrated that the administration of Letrozole orally resulted in the development of polycystic ovarian disease. The results indicated heightened levels of blood glucose, total cholesterol, and triglycerides, as well as alterations in hormone levels such as increased testosterone and estrogen, and decreased progesterone. These hormonal changes were accompanied by menstrual irregularities, which were confirmed through the examination of vaginal smears and histopathological analysis of the ovaries in the control group with polycystic ovarian disease. The treatment groups that received Agaricus subrufescens exhibited a decrease in blood glucose, total cholesterol, and testosterone levels.

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Effect of Sargassum Ilicifolium on Ovogenesis in Pcos Induced Rats

Cited by 6 publications

References 11 publications

Therapeutic potential of hydrolysable tannin on weight management oxidative stress and reproductive health in polycystic rats

Therapeutic potential of hydrolysable tannin on weight management oxidative stress and reproductive health in polycystic rats

The effect of dapsone in testosterone enanthate-induced polycystic ovary syndrome in rat

Agaricus Subrufescens ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with Letrozole induced polycystic ovarian syndrome

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