Effect of Schisandra chinensis Baillon extracts and regular low-intensity exercise on muscle strength and mass in older adults: a randomized, double-blind, placebo-controlled trial

Abstract

Background Studies suggest that Schisandra chinensis Baillon (Sc) may enhance muscle strength and mass because of its anti-inflammatory and antioxidant properties. Objectives We aimed to examine the effects and safety of consumption of Sc extract (SCe) for 12 wk on muscle strength and mass in older adults with relatively low muscle mass who do low-intensity exercise. Methods A randomized, double-blind, placebo-controlled trial was performed in adults >50 y of age. Fifty-four participants were randomly assigned into 2 groups and, for 12 wk, received either 1 g SCe/d or a placebo. All participants were required to walk for 30–60 min/d for >3 d/wk during the trial period. At baseline and at 4 and 12 wk after treatment, the participants were examined for knee extension strength using Biodex isokinetic dynamometers, handgrip strengths, and body composition, and blood tests were performed. The Euro-QoL-5D (EQ-5D) questionnaire and the FFQ were administered at baseline and at 12 wk after treatment. Physical activity was assessed using a self-recorded daily exercise log and an accelerometer during the study. Results SCe supplementation over 12 wk caused a higher increase in right knee extensor strength by 10.2 Nm (95% CI: 3.7, 16.8 Nm; P = 0.003) and left knee extensor strength by 6.7 Nm (95% CI: 0.3, 13.1 Nm; P = 0.041) than did the placebo. However, no differences were observed in the muscle mass, anti-inflammatory markers, antioxidative markers, and EQ-5D score between the groups. None of the participants experienced adverse events. Conclusions SCe supplementation may enhance skeletal muscle strength but not mass in older adults who perform low-intensity exercise. This trial was registered at clinicaltrials.gov as NCT03402308.

Effect of Ishige okamurae extract on musculoskeletal biomarkers in adults with relative sarcopenia: Study protocol for a randomized double-blind placebo-controlled trial

“…Subjects of the following criteria will be considered to have dropped out or discontinued participation in the trial and will be excluded from the per-protocol analysis: failure to take the IOE supplementation or placebo for five consecutive days, failure to attend follow-up assessments, and poor compliance (< 80%). This study protocol is similar to our previously published study (13).…”

Effect of fermented oyster (Crassostrea gigas) extracts and regular walking on muscle strength and mass in older adults with relatively low muscle mass: A randomized controlled trial

“…On the contrary, the current study was conducted for 12 weeks. The number of subjects for whom statistical power was calculated based on a prior study ( 19 ) was included. Both men and women were included, and the supplement dosage was slightly increased.…”

“…We used MedCalc version 19.4.1 (MedCalc Software Ltd., Ostend, Belgium) to calculate the sample size, which was based on a similar earlier study ( 19 ). The estimated sample size was 18 subjects per group for 80% power to detect a difference of 4.36 Nm mg/dL in average knee extension peak TQ at an angular velocity of 60°/s, assuming an SD of 4.6 Nm in the primary outcome variable and an α error of 5%.…”

Systematic analysis of the pharmacological function of Schisandra as a potential exercise supplement

“…However, recently published studies seem to view 1 g/day as the optimal dose. Cho et al reported that SCs supplementation (1 g/day) can enhance skeletal muscle strength but not mass in older adults who perform low-intensity exercise [ 42 ]. In addition, the results of Jang et al have shown that supplementation with SC (1 g/day) may help to improve QMS and decrease lactate levels in adult women [ 17 ].…”