Effect of SCN on Twin Single Twitch Muscle Fibers of the Frog

Oota, Isao; Nagai, Isaku; Nagai, Torao

doi:10.2170/jjphysiol.30.231

Jpn.J.Physiol

1980

DOI: 10.2170/jjphysiol.30.231

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Effect of SCN on Twin Single Twitch Muscle Fibers of the Frog

Isao Oota¹,

Isaku Nagai

Torao Nagai³

Abstract: The effects of SCN on the twitch responses, the duration of the active state during a single twitch and the negative afterpotential were

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1986

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Mechanism for the opioid-induced twitch potentiations of frog's skeletal muscle

Shetty¹,

Frank²

1986

Can. J. Physiol. Pharmacol.

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The twitch-potentiating effects of opioids in the frog's skeletal muscle which are naloxone resistant and nonstereospecific were further studied. The rapid kinetics of the onset and of the offset (following washout) of the opioid effect indicates that the site for this action is the surface membrane of the muscle fibre. On the other hand, the lack of any twitch-potentiating effect by naloxone methylbromide, a quaternary derivative of naloxone, suggests that opioids which potentiate the twitch must enter the lipid phase of the membrane to act. Intracellular microelectrode experiments revealed no relation between the opioid effects on membrane electrical events and twitch potentiation. Blocking slow calcium channels with D-600 did not modify the opioid-induced twitch potentiation. The twitch potentiation was antagonized by increasing the extracellular calcium concentration, [Ca2+]o, to 8.64 mM. The effects of closely spaced multiple electrical pulses revealed that the opioids decreased the summated response relative to predrug controls. The results suggest that opioids facilitate the process of excitation-contraction coupling in the frog's skeletal muscle by the release of an additional amount of "trigger calcium" following a single electrical stimulus, thereby generating a potentiated twitch.

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Mechanism for the opioid-induced twitch potentiations of frog's skeletal muscle

Shetty¹,

Frank²

1986

Can. J. Physiol. Pharmacol.

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show abstract

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Effect of SCN on Twin Single Twitch Muscle Fibers of the Frog

Abstract: The effects of SCN on the twitch responses, the duration of the active state during a single twitch and the negative afterpotential were

Cited by 1 publication

References 15 publications

Mechanism for the opioid-induced twitch potentiations of frog's skeletal muscle

Mechanism for the opioid-induced twitch potentiations of frog's skeletal muscle

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