2018
DOI: 10.1002/hup.2684
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Effect of GAD1 genotype status on auditory attention and acute nicotine administration in healthy volunteers

Abstract: Objective The effects of GABA modulating drugs and nicotine, the prototypical nicotinic cholinergic agonist, on attention have been investigated using subcomponents of the P300 event‐related potentials (ERP), which index involuntary (P3a) and voluntary attention (P3b). However, investigations into how such pharmacologic effects interact with genetic features in the GABA system remain unclear. This study examined the moderating effects of a single nucleotide polymorphism (rs7557793) in the glutamic acid decarbo… Show more

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