2024
DOI: 10.1002/jsfa.13297
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Effect of in vitro simulated digestion on the physicochemical properties and pancreatic lipase inhibitory activity of fucoidan

Chunqi Lu,
Qiuya Gu,
Xiaobin Yu

Abstract: BACKGROUNDFucoidan has an anti‐obesity effect. However, there are few studies on its mechanism. In this study, we investigated the in vitro and in silico inhibitory properties of fucoidan against pancreatic lipase for the first time. We examined the changes in composition, structure, and pancreatic lipase inhibition of fucoidan during in vitro digestion.RESULTSSimulated saliva‐gastrointestinal digestion resulted in a slight decrease in the molecular weight of fucoidan but no significant changes in the monosacc… Show more

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