Effect of Secretin and Caerulein on the Absorption of Water, Electrolytes and Glucose from the Jejunum of Dogs

Hirose, Shoichiro; Shimazaki, K.; Hattori, Nobu

doi:10.1159/000199369

Cited by 6 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…103,104 Moreover, secretin could trigger, via its receptor on the smooth musculature, the relaxation of rat ileal and colonic longitudinal muscle, 105 and dog duodenum after vagotomy. 106 Finally, secretin has also been shown to (a) stimulate the secretion of bicarbonate, protein, mucus, and epidermal growth factor from the Brunner's glands [107][108][109] ; (b) affect the maturation of gastrointestinal functions in suckling rat 110 ; (c) inhibit the absorption of water, sodium, and glucose from the dog jejunum and the rat ileum 111,112 ; and (d) increase the weight, DNA, and protein content of the rat small intestine. 113…”

Section: In the Intestinementioning

confidence: 99%

Secretin: A Pleiotrophic Hormone

Chu

Yung

Chow

2006

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Secretin holds a unique place in the history of endocrinology and gastrointestinal physiology, as it is the first peptide designated as a hormone. During the last century since its first discovery, the hormonal effects of secretin in the gastrointestinal tract were extensively studied, and its principal role in the periphery was found to stimulate exocrine secretion from the pancreas. Recently, a functional role of secretin in the brain has also been substantiated, with evidence suggesting a possible role of secretin in embryonic brain development. Given that secretin and its receptors are widely expressed in multiple tissues, this peptide should therefore exhibit pleiotrophic functions throughout the body. The present article reviews the current knowledge on the central and peripheral effects of secretin as well as its therapeutic uses.

show abstract

Section: In the Intestinementioning

confidence: 99%

Secretin: A Pleiotrophic Hormone

Chu

Yung

Chow

2006

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…In addition to ingested nutrients, pancreatic proteases also break the secretin releasing peptide, creating a negative feedback loop for secretin release ( 23 ). Secretin also induces biliary secretion of water, bicarbonate and chloride ( 28 ), but not bile acids ( 29 ), while inhibiting the absorption of water, sodium, and glucose in the jejunum and ileum ( 30 – 33 ).…”

Section: Regulation Of Secretin Secretion and Gastrointestinal Effectsmentioning

confidence: 99%

Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?

et al. 2021

View full text Add to dashboard Cite

Secretin is the first hormone that has been discovered, inaugurating the era and the field of endocrinology. Despite the initial focus, the interest in its actions faded away over the decades. However, there is mounting evidence regarding the pleiotropic beneficial effects of secretin on whole-body homeostasis. In this review, we discuss the evidence from preclinical and clinical studies based on which secretin may have a role in the treatment of obesity.

show abstract

“…In humans (Dinoso et al 1973) and dogs (Ramirez & Farrar 1970, Hirose et al 1986, secretin inhibits the small intestine and colon contraction activity. Moreover, secretin has been demonstrated to inhibit the absorption of water, sodium, and glucose from dog jejunum and rat ileum (Pansu et al 1980, Hirose et al 1986, and increase the weight, DNA, and protein content of the rat small intestine (Hoang et al 1988). …”

Section: Secretin Serves As a Gastrointestinal Hormone In Both Nonmammentioning

confidence: 99%

MOLECULAR EVOLUTION OF GPCRS: Secretin/secretin receptors

Tam

Lee

Jin

et al. 2014

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic secretion. To date, secretin has only been identified in tetrapods, with the earliest diverged secretin found in frogs. Despite being the first hormone discovered, secretin's evolutionary origin remains enigmatic, it shows moderate sequence identity in nonmammalian tetrapods but is highly conserved in mammals. Current hypotheses suggest that although secretin has already emerged before the divergence of osteichthyans, it was lost in fish and retained only in land vertebrates. Nevertheless, the cognate receptor of secretin has been identified in both actinopterygian fish (zebrafish) and sarcopterygian fish (lungfish). However, the zebrafish secretin receptor was shown to be nonbioactive. Based on the present information that the earliest diverged bioactive secretin receptor was found in lungfish, and its ability to interact with both vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide potently suggested that secretin receptor was descended from a VPAC-like receptor gene before the Actinopterygii-Sarcopterygii split in the vertebrate lineage. Hence, secretin and secretin receptor have gone through independent evolutionary trajectories despite their concurrent emergence post-2R. A functional secretin-secretin receptor axis has probably emerged in the amphibians. Although the pleiotropic actions of secretin are well documented in the literature, only limited information of its physiological functions in nonmammalian tetrapods have been reported. To decipher the structural and functional divergence of secretin and secretin receptor, functional characterization of the ligandreceptor pair in nonmammals would be the next perspective for investigation.

show abstract

Effect of Secretin and Caerulein on the Absorption of Water, Electrolytes and Glucose from the Jejunum of Dogs

Cited by 6 publications

References 16 publications

Secretin: A Pleiotrophic Hormone

Secretin: A Pleiotrophic Hormone

Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?

MOLECULAR EVOLUTION OF GPCRS: Secretin/secretin receptors

Contact Info

Product

Resources

About