Effect of Secretin on Acid and Pepsin Secretion in Cat and Dog

Stening, G. Frank; Johnson, Leonard R.; Grossman, Morton I.

doi:10.1016/s0016-5085(69)80153-8

Cited by 90 publications

(14 citation statements)

References 18 publications

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“…Secretin has been shown to inhibit acid secretion stimulated by food and antral irrigation ( l ) , duodenal distension ( 2 ) , intestinal stimulation (3), and exogenous gastrin (4). Although pure secretin is a potent inhibitor of gastrin-stimulated secretion in the dog ( 5 ) , it has little effect on gastric acid secretion in the cat (6).…”

Section: Effect Of Secretin and Cholecystokinin On Thementioning

confidence: 99%

Effect of Secretin and Cholecystokinin on the Response of the Gastric Fistula Rat to Pentagastrin

Tumpson

Johnson

1969

Experimental Biology and Medicine

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Section: Effect Of Secretin and Cholecystokinin On Thementioning

confidence: 99%

Effect of Secretin and Cholecystokinin on the Response of the Gastric Fistula Rat to Pentagastrin

Tumpson

Johnson

1969

Experimental Biology and Medicine

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“…A number of studies in animals have shown that as pure preparations as can be obtained of secretin alone (Wormsley and Grossman, 1964;Johnson and Grossman, 1968;Stening, Johnson, and Grossman, 1969a) and cholecystokinin are capable of inhibiting gastric acid secretion (Bedi et al, 1967;Stening, Johnson, and Grossman, 1969b). It has been suggested that secretin might account for all the inhibition of gastric acid secretion produced by duodenal acidification in the dog (Johnson and Grossman, 1968;Johnson and Grossman, 1969).…”

Section: Discussionmentioning

confidence: 99%

Secretin and cholecystokin/pancreozymin in combination in the inhibition of gastric acid secretion

Bedi¹,

Debas²,

Wasunna³

et al. 1971

Gut

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SUMMARY Both secretin, and the single substance which possesses both cholecystokinin and pancreozymin activity, have been shown to inhibit gastric acid secretory responses. Since potentiation may occur between pairs of stimulants of gastric secretion, the effects of combining secretin and cholecystokiniu/pancreozymin have been studied in Heidenhain pouches stimulated by continuous intravenous pentagastrin. Evidence suggesting potentiation between these two inhibitor agents is presented.Inhibition of gastric acid secretion is caused when the mucosa of the upper small intestine is bathed either by fat (Feng, Hou, and Lim, 1929), acid (Sokolov, 1904) or hyperosmolar solutions (Konturek and Grossman, 1965). The studies of Andersson (1960) suggest that the inhibition caused by acid in the duodenum is mediated by a humoral agent. There is therefore interest in the possible inhibitor properties on gastric acid secretion of extracts prepared from duodenal mucosa (Jorpes, 1968). Under certain experimental conditions in dogs, relatively pure secretin (Gillespie and Grossman, 1964a;Wormsley and Grossman, 1964) and relatively pure cholecystokinin/pancreozymin Grossman, 1964, Bedi, Govaerts, Master, andGillespie, 1967) have been demonstrated to inhibit Heidenhain pouch acid responses to stimulation by gastrin and it has been suggested that these agents may in fact be the principal mediators of the inhibition.There is evidence of potentiation at the level of the acid-producing cells between pairs of stimulants, eg, gastrin extract and stable choline ester (Gillespie and Grossman, 1964b), and gastrin and histamine (Passaro, Gillespie, and Grossman, 1964). Bedi, Debas, Gillespie, and Gillespie (1971) have also shown potentiation between bile salts and acetylcholine in the release of gastrin from the pyloric antrum. It is possible that potentiation may also exist between various inhibitors of gastric acid secretion. The present experiments were therefore designed to explore the possibility that both secretin and cholecystokinin/pancreozymin acting together may result in facilitated or potentiated inhibition.Received for publication 17 September 1971. Materials and MethodsThe observations were made on three dogs with Heidenhain type fundic pouches, the gastrointestinal tract otherwise being intact. The dogs' weights were between 15 and 20 kg and all operative procedures had been completed more than three months before the present experiments.Acid secretion from the Heidenhain pouch was stimulated by a continuous constant-rate intravenous infusion of pentagastrin at a dose which gave the maximal acid response from the Heidenhain pouch. During each experiment the secretion from the Heidenhain pouch was collected continuously, and every 15 minutes the volume was measured in millilitres and the acid concentration estimated by titration against 0 01N sodium hydroxide with phenol red indicator, end-point 6.8 to 8.4. Acid outputs were derived from multiplication of the volume and concentration values. A plateau of acid secretion from...

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“…Yalow and Berson (1970) found that elevated gastrin levels were lowered by the intragastric instillation of hydrochloric acid in five patients with pernicious anaemia, suggesting that the gastrin-producing cells are still subject to normal autoregulation. The present study has explored the effect of both the gastric mechanism dependent on pH and one of the duodenal mechanisms inhibiting gastrin action, and possibly gastrin release, namely, secretin (Wormsley and Grossman, 1964;Wormsley, 1968;Stening, Johnson, and Grossman, 1969).…”

Section: Lack Of Inhibition Of Gastrin Releasementioning

confidence: 99%

Radioimmunoassay of gastrin: studies in pernicious anaemia

Hansky¹,

Korman²,

Soveny³

et al. 1971

Gut

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SUMMARY Serum gastrin levels in patients with pernicious anaemia were measured by immunoassay in the fasting state, following gastric perfusion with 0.9%% saline, OIN hydrochloric acid, and solutions of increasing acidity, and after the intravenous injection or infusion of secretin. The fasting serum gastrin level was measured in 21 patients with pernicious anaemia and found to be elevated at 1,036 ± 215 pg per ml. Gastric perfusion with saline (pH 4.7) caused a mean fall in serum gastrin of 30 % in four patients; perfusion with hydrochloric acid caused a further slight fall. Perfusion with solutions of increasing acidity resulted in a sharp fall in serum gastrin levels when the acidity was changed from pH 6 to pH 4. A single intravenous injection of secretin produced a mean maximal fall of 440% in the serum gastrin level in four patients, whereas continuous infusion of secretin produced a fall of 35 in four other patients. These studies suggest that the gastrin-secreting cells of the stomach are not affected by the atrophic process in pernicious anaemia and remain subject to the regulating control of acid and secretin.

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Effect of Secretin on Acid and Pepsin Secretion in Cat and Dog

Cited by 90 publications

References 18 publications

Effect of Secretin and Cholecystokinin on the Response of the Gastric Fistula Rat to Pentagastrin

Effect of Secretin and Cholecystokinin on the Response of the Gastric Fistula Rat to Pentagastrin

Secretin and cholecystokin/pancreozymin in combination in the inhibition of gastric acid secretion

Radioimmunoassay of gastrin: studies in pernicious anaemia

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