Effect of secretin on plasma motilin in man.

Abstract

SUMMARY Graded doses of 0 1, 0*3, 0 9, and 2-7 clinical units/kg/h of pure synthetic secretin were infused over 60 minute periods in six healthy volunteers. Duodenal bicarbonate output and pH were recorded and plasma secretin and motilin levels were measured by radioimmunoassay. During the infusions plasma motilin fell in a dose dependent manner to a nadir of 35 %. This fall was linearly correlated with pancreatic bicarbonate output, whereas a non-linear correlation was observed between plasma motilin and both plasma secretin level and duodenal pH. It is suggested that plasma motilin levels are decreased by secretin-induced pancreatic bicarbonate juice flow. This may be important for the control of motilin secretion initiated by duodenal acidification and the concomitant delay in gastric emptying.Motilin, a recently discovered hormonal peptide from the small intestine (Brown et al., 1971), has been shown to increase lower oesophageal sphincter pressure and to delay gastric emptying in man (Ruppin et al., 1975; Rosch et al., 1976).So far, no physiological regulation of motilin secretion has been ascertained. In the dog it has been reported that serum motilin levels are raised by strong duodenal alkalinisation (Dryburgh and Brown, 1975). We have shown recently that, in man, motilin is released by duodenal acidification and after intraduodenal instillation of tris buffer (pH 102) motilin fell . As, however, a duodenal pH of 10-2 is unlikely to be achieved under normal conditions, the significance of this finding is uncertain. The present study was designed to assess the effect on motilin release of secretin. This peptide initiates a physiological alkalinisation of the duodenum by stimulating endogenous alkaline pancreatic juice flow (Jorpes and Mutt, 1961). MethodsSix healthy volunteer men (aged 23-42 years) were "Address for reprint requests:

The influence of herbal medicine on serum motilin and its effect on human and animal model: a systematic review

“…Notably, previous studies have reported that secretin does not affect serum MLN levels in dogs (Lee et al, 1980;Poitras et al, 1993). In this review and in Deloose et al (2019), however, secretin showed a negative correlation with serum MLN levels, and this result has been replicated in a study using pigs and in human clinical studies (Mitznegg et al, 1977;Jenssen et al, 1986;Dong et al, 2012).…”

Importance of the enteric nervous system in the control of the migrating motility complex

“…The duodenectomy also decreased plasma motilin level only in part (271). This may further confirm that there is still another pathway for the motilin action and the source of motilin release, since in the postprandial period, nutrients and hormones, such as secretin or pancreatic polypeptide (PP), can hamper motilin-evoked effect (37,126,172). There are several reasons to assume that motilin release from endocrine cells, in response to various regulatory factors, can be amplified by intestinal contractions.…”

The Role of Gasotransmitters in Gut Peptide Actions

“…A small reduction occurs after the administration of glucose, but lipids markedly increase the release of motilin ( Mitznegg et al, 1976 ). Other hormones such as insulin, SST, and secretin reduce motilin levels ( Mitznegg et al, 1977 ; Jenssen et al, 1984 ; Jenssen et al, 1986 ). In the gastrointestinal tract, motilin increases the pressure of LES, initiates gastric phase III contractions of the MMC, stimulates gastric emptying, inhibits gastric accommodation and increases rectal compliance in humans ( Domschke et al, 1976 ; Bormans et al, 1987 ; Peeters et al, 1992 ; Kamerling et al, 2003 ; Cuomo et al, 2006 ).…”