Effect of seeded surface area on crystal size distribution in glycine batch cooling crystallization: a seeding methodology

Optimal seed recipe design for crystal size distribution control for batch cooling crystallisation processes

“…In addition, quantitative information on the quality and property of seeds are seldom considered in the control of the process, and variations in seed CSD and property are generally considered as uncertainties rather than actuators for the control of the final CSD. Seeding seems to be treated as an art rather than science (Adi et al, 2007;Jagadesh et al, 1999;Kalbasenka et al, 2007;Kubota et al, 2001;Ludwick and Henderson, 1968;Lung-Somarriba et al, 2004) and generally there is a lack of systematic methodologies related to the amount and size of seeds that should be added into a crystallizer to obtain a product with a desired size distribution. Although it is recognized that the most important manipulated variables for the optimisation of crystallisation processes are supersaturation trajectories as well as the seed characteristics (Bohlin and Rasmuson, 1996;Heffels and Kind, 1999;Kalbasenka et al, 2007;Ruf et al, 2000, Yannick et al, 2009, the number of approaches focusing on temperature or anti-solvent addition trajectory optimisations is disproportionally higher than contributions considering seed recipe optimisations.…”

Seeded batch crystallization of ammonium aluminum sulfate from aqueous solution

“…It is even said to be mysterious. In the last decade, however, research papers dealing with seeding effects in batch crystallization were published by Jagadesh et al [4,5], Kubota et al [6], Doki et al [7][8][9][10][11][12], Serrena et al [13], Lung-Sommariba et al [14], Hojjati and Rohani [15] and Warstat and Ulrich [16]. One of the most important results obtained by these studies is a finding of the existence of a critical loading of seed crystals.…”

Adjustment of Process Conditions in Seeded Batch Cooling Crystallization

“…In order to compare the obtained results, the surface area and average crystal size of added seeds were determined. Since addition of seeds to the solution reduces further nucleation, CSD can be controlled when the seed surface area is over a certain value [18,19]. In the current case, multimodal CSD was avoided when the surface area was > 0.030 m 2 (Fig.…”