Effect of selected single nucleotide polymorphisms in SLC11A1, ANKRA2, IFNG and PGLYRP1 genes on host susceptibility to Mycobacterium avium subspecies paratuberculosis infection in Indian cattle

Gopi, B; Singh, Rajbir; Kumar, Satish; Kumar, Sushil; Chauhan, Anuj; Sonwane, Arvind; Kumar, Amit; Bharati, Jaya; Singh, Shoor Vir

doi:10.1007/s11259-021-09849-5

Cited by 5 publications

(2 citation statements)

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“…The results of the present study indicate a significant correlation between the genotype and the percentage of cows culled in subsequent lactations (Table 5). In comparison with the other genotypes, CC was found to be responsible for the increased https://doi.org/10.17221/194/2022-CJAS Nevertheless, Gopi et al (2022) studied the relationship between the polymorphism of two SNPs (rs68268263 and rs110217377) in the PGLYRP1 gene in an Indian cattle population and the susceptibility of the host to Mycobacterium avium ssp. Paratuberculosis (MAP) infection.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of the PGLYRP1 gene, the value of selected performance and functional traits, and causes of culling in Holstein-Friesian red-white cows

Sablik,

Dybus,

Januś

et al. 2023

Czech J. Anim. Sci.

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This research paper addresses the hypothesis that the peptidoglycan recognition protein 1 (PGLYRP1) gene polymorphism (Tyr76His; dbSNP ID: ss104796364) has an influence on some performance traits and causes of culling in Polish Holstein-Friesian red-white cows. The study involved 134 cows kept on a farm in the southwest of Poland. PGLYRP1 genotypes TT, CT, and CC were detected. It was shown that compared with cows with genotypes CT and TT, the individuals with genotype CC were characterised by higher lifetime yields and higher amounts of lactation milk, fat, and protein. A beneficial effect of genotype CC, compared with genotype TT, was also noted in the case of the lifespan and, consequently, the length of the productive life and the average number of lactations. Diseases of the musculoskeletal system (genotypes CC and TT) and disorders of the reproductive system (genotype CT) were the most common causes of culling. An essential practical observation was the potentially higher susceptibility of cows with genotype CC to mastitis, which resulted in the necessity to cull over one-fifth of the animals in this group. Simultaneously, no cows in this group were culled due to low performance or metabolic, gastrointestinal, and respiratory diseases. Therefore, the PGLYRP1 gene seems to be a promising potential herd health marker; however, to consider it the main gene, it is necessary to extend the investigations to include more individuals and other breeds of dairy cattle.

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Section: Discussionmentioning

confidence: 99%

Polymorphism of the PGLYRP1 gene, the value of selected performance and functional traits, and causes of culling in Holstein-Friesian red-white cows

Sablik,

Dybus,

Januś

et al. 2023

Czech J. Anim. Sci.

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“…Susceptibility and resistance to bovine paratuberculosis are associated with genetic variation in interferon gamma (IFNγ) and interleukin (IL) receptor 10, among other factors [31,32]. In a previous study, we detected two different immune phenotypes in cattle in Germany [33].…”

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confidence: 99%

Cathepsin S Is More Abundant in Serum of Mycobacterium avium subsp. paratuberculosis-Infected Dairy Cows

Duda,

von Toerne,

Korbonits

et al. 2024

Metabolites

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Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of bovine paratuberculosis, a chronic granulomatous enteritis leading to economic losses and posing a risk to human health due to its zoonotic potential. The pathogen cannot reliably be detected by standard methods, and immunological procedures during the infection are not well understood. Therefore, the aim of our study was to explore host–pathogen interactions in MAP-infected dairy cows and to improve diagnostic tests. Serum proteomics analysis using quantitative label-free LC-MS/MS revealed 60 differentially abundant proteins in MAP-infected dairy cows compared to healthy controls from the same infected herd and 90 differentially abundant proteins in comparison to another control group from an uninfected herd. Pathway enrichment analysis provided new insights into the immune response to MAP and susceptibility to the infection. Furthermore, we found a higher abundance of Cathepsin S (CTSS) in the serum of MAP-infected dairy cows, which is involved in multiple enriched pathways associated with the immune system. Confirmed with Western blotting, we identified CTSS as a potential biomarker for bovine paratuberculosis. This study enabled a better understanding of procedures in the host–pathogen response to MAP and improved detection of paratuberculosis-diseased cattle.

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Phylogenetic and Multiple-Locus Variable number tandem repeat analysis of Mycobacterium avium subsp. paratuberculosis isolates from Argentina

et al. 2022

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Effect of selected single nucleotide polymorphisms in SLC11A1, ANKRA2, IFNG and PGLYRP1 genes on host susceptibility to Mycobacterium avium subspecies paratuberculosis infection in Indian cattle

Cited by 5 publications

References 78 publications

Polymorphism of the PGLYRP1 gene, the value of selected performance and functional traits, and causes of culling in Holstein-Friesian red-white cows

Polymorphism of the PGLYRP1 gene, the value of selected performance and functional traits, and causes of culling in Holstein-Friesian red-white cows

Cathepsin S Is More Abundant in Serum of Mycobacterium avium subsp. paratuberculosis-Infected Dairy Cows

Phylogenetic and Multiple-Locus Variable number tandem repeat analysis of Mycobacterium avium subsp. paratuberculosis isolates from Argentina

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