2001
DOI: 10.1006/bbrc.2001.5171
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Effect of Selenium and Vitamin E Deficiency on Differential Gene Expression in Rat Liver

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Cited by 99 publications
(56 citation statements)
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References 30 publications
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“…We have proposed an alternate function for a-tocopherol, specifically that of a 'regulator of gene expression' (Marilley et al, 1996;Fazzio et al, 1997;Azzi et al, 1998b). This function, independent of the radical chain-breaking ability attributed to tocopherols, has been confirmed in a number of experiments, both in vitro and ex vivo (Prasad et al, 1990(Prasad et al, , 1993Houglum et al, 1991;Stauble et al, 1994;Marilley et al, 1996;Fazzio et al, 1997;Chojkier et al, 1998;Aratri et al, 1999;Ricciarelli et al, 2000;Davies et al, 2001;Fischer et al, 2001a;Gysin et al, 2002;Gohil et al, 2003;Landes et al, 2003). This may either result from the regulation of gene transcription or from affecting mRNA or protein stability.…”
Section: Introductionmentioning
confidence: 78%
See 1 more Smart Citation
“…We have proposed an alternate function for a-tocopherol, specifically that of a 'regulator of gene expression' (Marilley et al, 1996;Fazzio et al, 1997;Azzi et al, 1998b). This function, independent of the radical chain-breaking ability attributed to tocopherols, has been confirmed in a number of experiments, both in vitro and ex vivo (Prasad et al, 1990(Prasad et al, , 1993Houglum et al, 1991;Stauble et al, 1994;Marilley et al, 1996;Fazzio et al, 1997;Chojkier et al, 1998;Aratri et al, 1999;Ricciarelli et al, 2000;Davies et al, 2001;Fischer et al, 2001a;Gysin et al, 2002;Gohil et al, 2003;Landes et al, 2003). This may either result from the regulation of gene transcription or from affecting mRNA or protein stability.…”
Section: Introductionmentioning
confidence: 78%
“…This event may result in a reduction of glycoprotein IIb protein expression and thus contribute to anti-platelet aggregation (Chang et al, 2000). Combined a-tocopherol and selenium deficiency is characterized by alterations in the expression level of genes encoding for proteins involved in inflammation (multispecific organic anion exporter, SPI-3 serine protease inhibitor) and acute phase response (a-1 acid glycoprotein, metallothionein 1) (Fischer et al, 2001a). a-Tocopherol has an inhibitory effect on LDL-induced production of adhesion molecules and adhesion of monocytes to endothelial cells possibly via a direct regulatory effect on ICAM-1 expression (Martin et al, 1997).…”
Section: Group 4: Regulation Of Genes That Are Related To Inflammatiomentioning
confidence: 99%
“…Other factors may also be involved; for example, there is greater superoxide dismutase activity in cardiac than skeletal muscle (21). In other organs, a combined selenium and VE deficiency is often necessary to change more genes (22). Because of their large number, we cannot consider here all of the altered genes in detail; we discuss instead some of the larger and more significant changes.…”
Section: Discussionmentioning
confidence: 99%
“…DNA array technology has been applied already in numerous studies to determine nutrient-gene interaction (Fischer et al, 2001;Maxwell et al, 2003) for a variety of nutritional factors including zinc Lyons et al, 2001). The current value of DNA array use appears to be mainly that of a screening tool for identification of genes that show most pronounced changes in transcriptional regulation.…”
Section: Discussionmentioning
confidence: 99%