Effect of Selenium on Carbimazole-Induced Histopathological and Histochemical Alterations in Prostate of Albino Rats

Abstract

Carbimazole is an antithyroid drug used in treatment of hyperthyroidism. The present study is undertaken to evaluate the effect of carbimazole in prostate of albino rats and the ameliorative role of selenium. Treating rats with carbimazole(1.35mg/Kg b.w) daily for 8 weeks caused distinct histological alterations in prostate gland compared with control group. The epithelial cells of prostatic acini exhibited degeneration. Hyperplasia were projected into the lumens of the prostatic acini or to the outside stroma. Most of the intertubular blood vessels were congested. Histomorphological results showed that the heights of the epithelial cells were significantly reduced and the thickness of smooth muscle layer increased. Prostate gland of animals treated with carbimazole showed gradual decrease in the polysaccharide, protein and nucleic acids contents. These results were time-dependent. Treating animals with carbimazole and selenium showed an improvement in the histological structure as well as histochemical components of the prostate gland. It is suggested that the ameliorative effect of selenium against the histological and histochemical changes induced by carbimazole may be due to its antioxidant properties.

Histological and immunohistochemical study on the effect of gibberellic acid on the liver of adult male albino rats and the possible protective role of green tea

“…Similar results were described previously and were attributed to increased permeability of the cell membrane in response to cell injury leading to an increase in the volume of intracellular water as it sufficiently accumulates within the cell and produces cytoplasmic vacuolation [3]. It was suggested that injurious agents may also interfere with the ATP-dependent sodium-potassium pump by increasing the permeability of the cell membrane to sodium, thereby exceeding the capacity of the pump to extrude sodium, or damaging the pump directly.…”

“…Previous studies have proven that oral administration of GA3 induces different biochemical and histochemical changes in the liver of treated rats in the form of early increase followed by late decrease in liver enzymes and marked reduction in total carbohydrate and total protein content in hepatocytes [3].…”

“…It was first discovered by the Japanese, and was derived from the fungus Gibberella fujikuroi [2]. It is used extensively in Egypt and other countries to stimulate the growth of many fruits (such as strawberries and grapes) and vegetables (such as tomatoes, cabbage, and cauliflower) [3]. It is highly persistent and bioactive in soil for months.…”

Effect of high-fructose diet-induced metabolic syndrome on the pituitary-gonadal axis from adolescence through adulthood in male albino rats and the possible protective role of ginger extract. A biochemical, histological and immunohistochemical study

“…Intraepithelial vacuolization may be considered as a manifestation of testicular tubules' atrophy [87]. Sakr et al [66] attributed the vacuolated cytoplasm of spermatogenic cells to lipid peroxidation causing damage to the cell membrane and membranes of the cell organelles with subsequent increase in their permeability.…”

Impact of ginger aqueous extract on carbimazole induced testicular degenerative alterations and oxidative stress in albino rats

“…Group II rats were given 1 mL of ginger aqueous extract orally by a stomach tube (24 mg/mL) daily for three and six weeks. Group III rats were orally given carbimazole 1.35 mg/kg bw, equivalent to the therapeutic dose for human dissolved in distilled water by stomach tube [19]. Group IV rats were orally given 24 mg/mL of ginger extract by stomach tube followed by carbimazole (1.35 mg/kg bw) for three and six weeks.…”