Effect of Selenium on Dental Caries

Dm, Hadjimarkos

doi:10.1080/00039896.1965.10664115

Cited by 61 publications

(11 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It plays an essential role in energy metabolism, redox balance, and reproduction in a variety of organisms, from bacterial pathogens to eukaryotic parasites to humans. The results of several epidemiological studies indicate that higher levels of selenium in the mammalian diet can have a negative effect on dental health (2,(17)(18)(19)39). Although the impact of selenium is attributed to its influence on the physical properties of the enamel surface (10), the role of selenium in supporting the oral microbial community has not been studied.…”

mentioning

confidence: 99%

Inhibition of Selenium Metabolism in the Oral Pathogen Treponema denticola

Jackson-Rosario

Self

2009

J Bacteriol

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Inhibition of Selenium Metabolism in the Oral Pathogen Treponema denticola

Jackson-Rosario

Self

2009

J Bacteriol

View full text Add to dashboard Cite

show abstract

“…In our surveys, selenium levels in urine averaged less than 49 μg/L for persons in a high selenium area (soil and ground water) but consuming low-selenium water (11) and less than 33 μg/L for participants residing in low selenium areas (20), as shown in Table I. Hadjimarkos and Bonhorst (24) noted that the mean selenium levels determined in urine for their study, 76 μg/L, were indicative of selenium intake. However, selenium levels in drinking water were low in their study area (25). Longnecker et al (6) determined urine values of 2.14 μιηοΐ/d (168.97 μg/day) for persons residing in high selenium areas of the U.S. Water concentrations in their study were not reported.…”

Section: Selenium Body Burden Vs Low Water Seleniummentioning

confidence: 95%

Body Burden Concentrations in Humans in Response to Low Environmental Exposure to Trace Elements

Valentine¹

1997

ACS Symposium Series

View full text Add to dashboard Cite

Few studies have been published relating low trace element environmental exposures and resulting body burdens. This paper presents an evaluation of concentrations of arsenic and selenium in human urine when low concentrations, less than 30 μg/L, in the drinking water were consumed. Five communities for arsenic exposures and three communities for selenium exposures were selected. A good dose/response curve for selenium was obtained but the correlation coefficient, r = 0.9508, n = 3, was found not to be statistically significant (p > 0.10). A similar dose/response curve was obtained for arsenic and found to be statistically significant, r = 0.9898, n = 5, p < 0.002.Human body burden has been shown to reflect trace element intakes in the cases of both deficient and adequate dietary exposure to the trace element examined. An example of such a relationship can be made with the element selenium. Oster and Prellwitz (7) have shown that dietary selenium intake correlated well with selenium excreted in urine. This was determined using urine and dietary Se intake estimates from studies conducted by various researchers in China, New Zealand, Italy, France, West Germany, Japan, and Canada. Dietary intakes ranged from 11 μg/day to 750 μg/day with a seemingly good correlation as well at the low intake range of 11 μg/day to 50 μg/day. The lowest intake level reported by Oster and Prellwitz was taken from the study of Yang et al. (2). At this intake level, blood, hair, and urine concentrations of 2.1 μg/100 mL, 0.074 μg/g, and 7 μg/L were reported respectively.The study of Oster and Prellwitz (7) was followed by numerous reports of a linear correlation between dietary selenium intake and levels of selenium in whole blood and its components and in urine (3)(4)(5)(6)(7)(8). In contrast to the above studies, Thimaya and Ganapathy (9) found that hair selenium levels and dietary intake were not correlated in their study of 115 subjects. Selenium intakes ranged from 25 to 204 μg/day with a mean of 87±3 μg/day. However the extreme low value of 25 μg/day was reported for only one individual. Hair selenium levels in this study averaged 0.64±0.02 μ^/g. Similar evaluations for environmental exposure/body burden relationships have been conducted for the assessment of biological monitoring utility and for studies of potential toxicity. Creason et al. (10) evaluated the relationship of trace elements in hair and exposure to dustfall, house dust, and soil. They found Ni, Cr, Sn, Β a, Hg, Pb,

show abstract

“…They reviewed experimental work on rats which confirmed that selenium added to drinking water at levels as low as 2.3 mg Se L -1 and consumed at the time of tooth development increased the incidence of caries. They suggested that selenium might alter the protein component of enamel and reported some experimental work which suggested that the initial point of attack in the development of a carious lesion involved the protein of enamel (Hadjimarkos, 1965(Hadjimarkos, , 1969. In another study, Tank and Storvick (1960) surveyed high school children in Wyoming which has extensive seleniferous areas and widepsread vanadium deposits.…”

Section: Introductionmentioning

confidence: 94%

Trace elements in the human environment: Problems and risks

Davies

1994

Environ Geochem Health

View full text Add to dashboard Cite

Early studies on the possible influences of environmental geochemistry and health were concerned with major diseases such as cancer or multiple sclerosis. They were generally confined to simple comparisons of geochemical and epidemiological maps and corresponding rural areas. Subsequently, studies of dental health produced evidence for the roles of environmental fluoride, selenium, molybdenum and lead in the aetiology of caries. In recent decades lead has been closely studied. Most people in the western world live in urban areas, rather than rural areas, and research on lead has yielded much information on the distribution of the element in streets, parks and gardens of cities and in the home environment. The role of lead in human health has thereby been better understood. Cadmium, selenium and aluminium are good candidates for future study but success will depend on applying appropriate methods of investigation and here the experiences from research on lead are a valuable model to follow.

show abstract

Effect of Selenium on Dental Caries

Cited by 61 publications

References 27 publications

Inhibition of Selenium Metabolism in the Oral Pathogen Treponema denticola

Inhibition of Selenium Metabolism in the Oral Pathogen Treponema denticola

Body Burden Concentrations in Humans in Response to Low Environmental Exposure to Trace Elements

Trace elements in the human environment: Problems and risks

Contact Info

Product

Resources

About