Effect of selenium on pancreatic proinflammatory cytokines in streptozotocin-induced diabetic mice

Zeng, Jinhong; Zhou, Jun; Huang, Kaixun

doi:10.1016/j.jnutbio.2008.05.012

Cited by 57 publications

(27 citation statements)

References 51 publications

(72 reference statements)

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“…& Exp. Ltd., Sao Paulo, Brazil) at a dose of 2 mg/kg body weight/day diluted in distilled water orally by a gastric tube [23] till the end of the experiment.…”

Section: Methodsmentioning

confidence: 99%

Effect of experimentally induced diabetes on adult albino ratsʼ ventral prostate gland and role of selenium

El-Haleem

Zidan

2011

The Egyptian Journal of Histology

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IntroductionThe relationship between the occurrence of benign hyperplasia and prostatic cancer with diabetes is a controversial issue. Selenium has been found to alleviate diabetic complications in many organs. Aim of the study To clarify the impact of diabetes on the histological structure of the albino rats' ventral prostate gland and the possible role of selenium supplementation. Materials and methodsThirty adult male albino rats were divided equally into three groups. Group 1 served as control. Group 2 was given a single intraperitoneal injection of 65 mg/kg body weight streptozotocin. Group 3 in which the rats, 1 week after diabetes induction, received 2 mg/kg body weight/day sodium selenite orally. Thirty days after diabetes induction, all rats were weighed, anesthetized, and sacrificed. The ventral prostatic lobes were dissected out, weighed, and processed for light and electron microscope examinations. The area percentage of collagen fibers, epithelial height, and acinar diameter were morphometrically measured. Statistical analysis was carried out using SPSS program. ResultsExamination of the ventral prostate gland of rats from group 2 revealed that the diameter of most acini was highly significantly increased when comparing it with group 1. The epithelial height of their acini was highly significantly decreased when comparing with group 1. Acini were lined by flat-to-low cuboidal cells with few papillary projections. The acinar lining showed focal areas of stratification. Few acini had columnar epithelium. Most cells had irregular-shaped nuclei, a dilated rough endoplasmic reticulum, numerous electron-lucent vacuoles, and few secretory granules. Areas of irregular basement membrane were seen. Thick bundles of collagen fibers and cellular infiltration were seen. Examination of group 3 revealed that it nearly regained its normal architecture. Most acini had many papillary projections and were lined by columnar cells. Acinar cells had euchromatic basal nuclei, rough endoplasmic reticulum, and secretory granules of different sizes and densities, which might seem almost vacuolated with minimum secretory content. The body and prostatic weights were highly significantly lowered in group 2 in comparison with groups 1 and 3. Conclusion Diabetes mellitus had a deleterious effect on the histological structure of the ventral prostate gland, and selenium could ameliorate diabetic effects on the prostate.

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“…& Exp. Ltd., Sao Paulo, Brazil) at a dose of 2 mg/kg body weight/day diluted in distilled water orally by a gastric tube [23] till the end of the experiment.…”

Section: Methodsmentioning

confidence: 99%

Effect of experimentally induced diabetes on adult albino ratsʼ ventral prostate gland and role of selenium

El-Haleem

Zidan

2011

The Egyptian Journal of Histology

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“…However, no significant change in malondialdehyde (MDA) concentrations was seen after the consumption of selenium supplements in rats [16]. Beneficial effects of selenium supplementation on improved reproductive outcomes, biomarkers of inflammation, and oxidative stress might be attributed to its inhibitory effect on augmentation of proinflammatory cytokines and reactive oxygen species/reactive nitrogen species [17,18]. Borderline selenium status is high among healthy Iranian women.…”

Section: Affiliationsmentioning

confidence: 99%

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

et al. 2015

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Selenium supplementation could be effective on reproductive outcomes, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). The aim of the study was to determine the effects of selenium supplementation on reproductive outcomes, biomarkers of inflammation, and oxidative stress in PCOS patients. The present randomized double-blind, placebo-controlled trial was conducted on 64 women aged 18?40 years old with PCOS at the clinic affiliated to Ardabil University of Medical Sciences, Ardabil, Iran. The participants were randomly assigned to 2 groups receiving either 200??g selenium daily (n=32) or placebo (n=32) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured and compared both before and after the treatment. After 8 weeks of intervention, pregnancy rate in the selenium group was higher than in the placebo group: 18.8 (6/32) vs. 3.1% (1/32), p=0.04. In addition, alopecia (40.6 vs. 9.4%, p=0.004) and acne (46.9 vs. 12.5 %, p=0.003) decreased following the consumption of selenium supplements compared with placebo. Additionally, patients who received selenium supplements had significantly decreased serum dehydroepiandrosterone (DHEA) levels (p=0.02), hirsutism (modified Ferriman?Gallwey scores) (p<0.001), serum high sensitivity C-reactive protein (hs-CRP) (p=0.02), and plasma malondialdehyde (MDA) levels (p=0.01) compared with placebo. We did not observe any significant effects of taking selenium supplements on other hormonal profiles, nitric oxide (NO), and other biomarkers of oxidative stress. Taken together, selenium supplementation for 8 weeks among PCOS women had beneficial effects on reproductive outcomes, DHEA, hs-CRP, and MDA levels.

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“…Intraperitoneal injection or oral administration of sodium selenate improved glucose homeostasis in Type 1 and Type 2 diabetic animals [29][30][31][32][33]. Similarly, the insulin-like and anti-diabetic effects of sodium selenite and selenomethionine were also observed in diabetic animals [34][35][36][37][38][39], although their effects were shown to be weaker than sodium selenate. Mechanisms underlying differentiated effects of various selenium compounds have been reviewed [40].…”

Section: Two Tales Of Se On Diabetes Se As An Insulin Mimicmentioning

confidence: 99%

“…Mechanisms underlying differentiated effects of various selenium compounds have been reviewed [40]. However, all these insulin-like effects were mainly observed at high Se doses (0.9-4.5 mg/ kg body weight) [29][30][31][32][33][34][35][36][37][38][39].…”

Section: Two Tales Of Se On Diabetes Se As An Insulin Mimicmentioning

confidence: 99%

“…First, many of the past animal studies used diabetic animals [29][30][31][32][33][34][35][36][37][38][39], but the present studies have been conducted in normal animals [53,[57][58][59][60][62][63]. Second, the past experiments used high or nearly toxic doses of Se (0.9-4.5 mg/kg body weight) [29][30][31][32][33][34][35][36][37][38][39], while recent experiments used Se levels not exceeding their maximal tolerable limits (≤33.0 mg Se/kg diet). Finally, many of the past animal studies lasted only 2 to 8 weeks, whereas in most of recent animal studies the duration of Se supplementation has been 12 weeks or longer [53,[57][58][59][60][62][63].…”

Section: Perspective and Conclusionmentioning

confidence: 99%

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Selenium and diabetes - evidence from animal studies

Lei

2012

Free Radical Biology and Medicine

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Effect of selenium on pancreatic proinflammatory cytokines in streptozotocin-induced diabetic mice

Cited by 57 publications

References 51 publications

Effect of experimentally induced diabetes on adult albino ratsʼ ventral prostate gland and role of selenium

Effect of experimentally induced diabetes on adult albino ratsʼ ventral prostate gland and role of selenium

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

Selenium and diabetes - evidence from animal studies

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