This study aims to determine the influence of the Big Five personalities and the habit of memorizing the Quran through self-regulated learning mediators on mathematics learning achievement. Next, examine the effect of exogenous variables on endogenous variables directly or indirectly. This study uses a quantitative approach, the measuring tools used are the big five personality scale, the habit of memorizing the Qur'an, self-regulated learning, and using documents of mathematics achievement scores for the 2019/2020 academic year. We used the following data analyses: 1) measurement models, 2) structural equation models, and 3) measurement models, which were calculated through confirmatory factor analysis (CFA) of latent research variables. This study's participants were 113 students from two junior high schools in Yogyakarta, Indonesia. They were in grade eight and had a minimum of 3.5 juz of memorization of the Quran. The research findings showed that memorizing the Quran and the Big Five personalities impacted mathematics learning achievement through self-regulated learning mediator variables. There is no significant correlation between the Big Five personality traits and math learning achievement. Similarly, the practice of memorizing the Quran also shows negligible impact. Nonetheless, there is a significant correlation between the four – conscientiousness, neuroticism, agreeableness, openness to new experiences, and the habit of memorizing the Quran through self-regulated learning mediators on mathematics learning achievement. An extroverted personality directly influences mathematics learning achievement. Lastly, a significant correlation exists between mathematics learning achievement and self-regulated learning.