Effect of senescence on some apoptosis and oxidative stress markers in infertile normozospermic and oligospermic men: A cross-sectional study

Emokpae, Mathias Abiodun; Chima, Happy Ngozi

doi:10.29252/ijrm.16.7.435

Cited by 7 publications

(1 citation statement)

References 29 publications

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“…There are several factors that have the potential of altering the function of the hypothalamic-pituitary -gonadal axis; these factors include lifestyle factors such as smoking, diets, anxiety, alcohol, drugs misuse and risky sexual behaviours arising in infections, radiation (Emokpae & Chima, 2018;Adewumi, 2017;Acharya & Gowda, 2017). Infertile have also been reported to result from abnormalities in the pituitary-gonadal axis, this has been reported in Nigerian men (Ozoemena et al, 2011).…”

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confidence: 99%

A review of the effect of fertility agents (Herbs and drugs) on the hypothalamus

Grace UMAHI-OTTAH,

Faith Ayobamidele OBAFEMI

2023

World J. Adv. Res. Rev.

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The hypothalamus plays a central role in regulating fertility through its interactions with the hypothalamic-pituitary-gonadal (HPG) axis. This review provides a comprehensive analysis of the effects of fertility agents, including herbs and pharmaceutical drugs, on the hypothalamus and its role in fertility regulation. The hypothalamus directly influences the HPG axis by secreting GnRH, a hormone crucial for sexual development and ovulatory cycles. GnRH can be secreted in pulsatile or surge modes, with distinct implications for reproductive function. The HPG axis further regulates reproductive organs and hormonal production, affecting processes like oocyte maturation, ovulation, and steroid hormone synthesis. Herbal remedies have been used historically in various cultures to address fertility issues. Several plants, such as Withania somnifera, Punica granatum, Camellia sinensis, Matricaria chamomilla, Vitex agnus-castus, and Nigella sativa, have been studied for their potential to enhance fertility by modulating the HPG axis and influencing sex hormone levels. Pharmaceutical fertility drugs like clomiphene citrate and metformin also have a significant impact on the hypothalamus. Clomiphene citrate acts as a partial estrogen agonist in the hypothalamus, leading to increased gonadotropin-releasing hormone (GnRH) production and subsequent elevation of gonadotropin levels. Metformin, primarily used for diabetes management, can restore ovarian function in women with polycystic ovary syndrome (PCOS) and improve pregnancy outcomes. Understanding the intricate interactions between fertility agents and the hypothalamus is crucial for developing effective treatments for infertility and optimizing reproductive health.

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Section: Introductionmentioning

confidence: 99%

A review of the effect of fertility agents (Herbs and drugs) on the hypothalamus

Grace UMAHI-OTTAH,

Faith Ayobamidele OBAFEMI

2023

World J. Adv. Res. Rev.

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Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model

Jeremy

Gurusubramanian

Roy

2019

Molecular Reproduction Devel

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The present study aimed to investigate the effects of vitamin D3 in the epididymal sperm cells of D‐gal‐induced aged rats. It is well known that during aging sperm quality and quantity declines and leads to age‐related infertility problems in males. The results of the present study showed that there were elevated levels of oxidative stress and poor DNA integrity of sperm of aged rats. The expression of BCL2 also showed a significant decline in the sperm of aged rats, however, the expression of BAX and active caspase‐3 did not show significant change compared with the control group. The treatment of vitamin D3 at lower doses to aged rats showed increased expression of BAX and active caspase‐3 in the sperm, this finding suggests that increased apoptosis may be responsible for removal of poor quality sperm during aging. Vitamin D3 treatment at both doses showed improvement in the oxidative stress and DNA integrity in the sperm of aged rats. We also investigated the expression of AGER, visfatin, and HSPA1A in the epididymal sperm. It has been found that expression of AGER, visfatin, and HSPA1A increased in the sperm aged rats and vitamin D3 treatments at both doses decreased its expression. Thus, it might be suggested that during aging vitamin D3 treatment would be important for managing the sperm quality by regulating the apoptosis, antioxidant system and DNA integrity via modulation of visfatin and HSPA1A.

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Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Yang

Zhang

Xue

et al. 2020

Sci Rep

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Human microbiota play an important role in the health of their human hosts. Recent studies have demonstrated that microbiota exist in seminal plasma. The current study aims to elucidate whether seminal microbiota exist in patients with different types of dysspermatism and whether bacterial biomarkers can be identified for them. A total of 159 study participants were recruited, including 22 patients with oligoasthenospermia, 58 patients with asthenospermia, 8 patients with azoospermia, 13 patients with oligospermia, and 58 matched healthy controls. Seminal microbiota composition was analyzed using 16S rRNA gene-based sequencing. The results showed that the composition of seminal microbiota of patients with dysspermatism differed from those of healthy controls. Comparison of the microbiota composition in semen samples from patients with different types of dysspermatism showed that microbiota in patients with asthenospermia and oligoasthenospermia were distinct from healthy controls in beta diversity (P < 0.05). Characteristic biomarkers, including Ureaplasma, Bacteroides, Anaerococcus, Finegoldia, Lactobacillus and Acinetobacter lwoffii, were identified based on LEfSe analysis. Inferred functional analysis based on seminal microbiome data further indicated the presence of potential pathogenic biomarkers in patients with asthenospermia and oligoasthenospermia. These results provided profiles of seminal microbiota exhibited in different types of dysspermatism, thus providing new insights into their pathogenesis. Human microbiota, with its diverse relationships-commensal, parasitic, mutualistic, and pathogenic-play an important role in human health. Recent studies have reported that microbiota exist in almost every part of human body-even in the endocrine niche, such as in tumors, blood, and synovial fluid 1-4. Advances in technology and new research have demonstrated that microbiota are found in seminal plasma, and play an important role in host homeostasis 5. It has been demonstrated that the presence of bacteria in sperm is associated with male infertility 6. Some bacteria in the urogenital tract may affect spermatogenesis and decrease sperm quality through various means, including decrease in sperm motility, deficiency in DNA integrity, and destruction of mitochondrial function 7. Escherichia coli, Mycoplasma genitalium, Ureaplasma urealyticum, Mycoplasma hominis, Staphylococcus aureus, and Chlamydia trachomatis are pathogens associated with male infertility 8-12. Several studies using high-throughput sequencing have demonstrated that seminal plasma has a bacterial community, which includes Lactobacillus, Pseudomonas, Prevotella, and Gardnerella, among others 13-19 .

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Effect of senescence on some apoptosis and oxidative stress markers in infertile normozospermic and oligospermic men: A cross-sectional study

Cited by 7 publications

References 29 publications

A review of the effect of fertility agents (Herbs and drugs) on the hypothalamus

A review of the effect of fertility agents (Herbs and drugs) on the hypothalamus

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

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