EFFECT OF SENNA (Senna alexandrina Mill.) AND POMEGRANATE (Punica granatum L.) LEAVES EXTRACTS AND ITS FRACTIONS ON PRO-INFLAMMATORY CYTOKINES OF THE OBESE ZEBRAFISH (Danio rerio)

Yuniarto, Ari; Sukandar, Elin Yulinah; Fidrianny, Irda; Nasrullah, Hasan; Adnyana, I Ketut

doi:10.31788/rjc.2019.1235215

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…Kombinasi kayu secang, kayu manis, dan daun Ruella tersebut memberikan efek antioksidan dan antidiabetes dengan mekanisme penghambatan alpha glucosidase dan penangkapan radikal bebas (Rosmalena et al, 2022). Kombinasi daun jati cina dan delima dilaporkan memiliki aktivitas antidiabetes, antioksidan, dan antiobesitas (Yuniarto et al, 2018).…”

Section: Hasil Penelitianunclassified

Efek Hipoglikemia Formula Herbal Antidiabetes Pada Tikus Diabetes Yang Diinduksi Alloxan

Sarifah,

Jannah,

Sari

2024

JPSP

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Penelitian ini bertujuan untuk menguji efek hipoglikemia formula herbal antidiabetes secara in vivo. Herbal yang digunakan dalam penelitian yaitu simplisia daun kencana wungu, kayu secang, kayu manis, dan daun jati cina, dengan formula rasio yang digunakan 5:2:2:1 (F5221) dan rasio 3:3:2:2 (F3322). Sebanyak 12 tikus betina strain wistar dikelompokkan menjadi empat kelompok dengan jumlah masing-masing kelompok 3 ekor tikus. Kelompok perlakuan antara lain tikus normal, tikus diabetes mellitus (DMT2), tikus DMT2+ F3322, dan tikus DMT2+F5221. Tikus model diabetes mellitus diinduksi dengan menginjeksikan 175 mg/Kg BB alloxan secara subkutan dan melakukan observasi kadar glukosa darah 3 – 6 hari setelah injeksi. Selanjutnya tikus model diabetes diberikan formula herbal F3322 dan F5221 2x sehari selama 14 hari, dan dilakukan pengamatan kadar glukosa darah untuk mengamati efek hipoglikemia serta berat badan. Hasil pengamatan menunjukkan injeksi alloxan 175 mg/kg BB pada tikus model strain wistar meningkatkan kadar glukosa darah hingga lebih dari 200 mg/dl. Pemberian formula herbal 2x sehari pada hari ketujuh setelah perlakuan menunjukkan penurunan berat badan yang berbeda nyata (p0.05), demikian juga pada hari ke – 14 setelah perlakuan. Namun, pemberian formula herbal baik F3322 dan F5221 menormalkan kadar gula darah tikus model dari 415 – 445 mg/dl menjadi 155 – 157 mg/dl. Penurunan kadar glukosa pada tikus model disebabkan oleh kandungan daun kencana wungu, kayu secang, dan kayu manis yang memiliki efek hipoglikemia. Sedangkan daun jati cina berpotensi sebagai antidiabetes melalui efek hypolipidemia yang ditandai dengan penurunan berat badan tikus. Penelitian ini disimpulkan bahwa pemberian formula F5221 selama 2x sehari dalam 14 hari menurunkan kadar glukosa dan berat badan dan berpotensi sebagai kandidat obat herbal antidiabetes mellitus.

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Section: Hasil Penelitianunclassified

Efek Hipoglikemia Formula Herbal Antidiabetes Pada Tikus Diabetes Yang Diinduksi Alloxan

Sarifah,

Jannah,

Sari

2024

JPSP

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“…Yellow pea, aphaca, wild pea, Indian flower [214] Europe, Asia, Africa [214] Flower [214] na Seeds contain toxic amino acids [133] Senna, cassia, sen, cassia angustifolia [53,214] Egypt [214,215] Leaf, fruit, flower [53,214,216] Ericaceae Rhododendro n simsii Planch.…”

Section: Euphorbiace Aementioning

confidence: 99%

“…Activity: laxative, antipyretic, purgative, diuretic, stomach[53,215,216] Arial part: infusion Fabaceae Senna corymbosa (Lam.) H. S.Irwin & BarnebyButtercup bush, Argentine Senna, sena del campo, rama negra, mata negra[20,217,218] South America[20,217] Flower na Glycosides (anthraquinone glycosides, naphthoquinone), Activity: laxative, purgative, antidiabetic, hepatoprotective, antimalarial, antipyretic, antiasthmatic, antiviral, and antibacterial[20,217,218] Arial part: infusion na Alkaloids (grayanotoxane (pollen, nectar, and leaves)), phenols (flavonoids), and benzoic acid derivatives[207] Treatment: gastrointestinal disorders, asthma, arthritis, skin diseases, cough, resolving sore toxin, amenorrhea, expectorant, and bronchitis[207] Activity: anti-inflammatory, anti-herpes, antioxidant, antiviral, hepatoprotective, and sedative[207,208] Arialpart: infusion Euphorbiaceae Euphorbia milii Des Moul.…”

mentioning

confidence: 99%

Exploring Plants with Flowers: From Therapeutic Nutritional Benefits to Innovative Sustainable Uses

Coyago-Cruz,

Moya,

Méndez

et al. 2023

Foods

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Flowers have played a significant role in society, focusing on their aesthetic value rather than their food potential. This study’s goal was to look into flowering plants for everything from health benefits to other possible applications. This review presents detailed information on 119 species of flowers with agri-food and health relevance. Data were collected on their family, species, common name, commonly used plant part, bioremediation applications, main chemical compounds, medicinal and gastronomic uses, and concentration of bioactive compounds such as carotenoids and phenolic compounds. In this respect, 87% of the floral species studied contain some toxic compounds, sometimes making them inedible, but specific molecules from these species have been used in medicine. Seventy-six percent can be consumed in low doses by infusion. In addition, 97% of the species studied are reported to have medicinal uses (32% immune system), and 63% could be used in the bioremediation of contaminated environments. Significantly, more than 50% of the species were only analysed for total concentrations of carotenoids and phenolic compounds, indicating a significant gap in identifying specific molecules of these bioactive compounds. These potential sources of bioactive compounds could transform the health and nutraceutical industries, offering innovative approaches to combat oxidative stress and promote optimal well-being.

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“…Additionally, Vroegrijk et al [35] demonstrated that PG seed oil treatment can improve peripheral insulin sensitivity in C57Bl/J6 mice. Furthermore, α-glucosidase and α-amylase assays showed the capacity of PG leaf extract to inhibit these enzymes, and there were also reports of enzymatic inhibition of pancreatic lipase [80]. However, there have also been contradictory findings regarding the anti-hyperglycemic potential of PG [40,61].…”

Section: Type 2 Diabetes and Pomegranate Consumptionmentioning

confidence: 99%

The Modulatory Bioeffects of Pomegranate (Punica granatum L.) Polyphenols on Metabolic Disorders: Understanding Their Preventive Role against Metabolic Syndrome

Alami,

Boumezough,

Khalil

et al. 2023

Nutrients

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Modern research achievements support the health-promoting effects of natural products and diets rich in polyphenols. Pomegranate (PG) (Punica granatum L.) contains a considerable number of bioactive compounds that exert a broad spectrum of beneficial biological activities, including antimicrobial, antidiabetic, antiobesity, and atheroprotective properties. In this context, the reviewed literature shows that PG intake might reduce insulin resistance, cytokine levels, redox gene expression, blood pressure elevation, vascular injuries, and lipoprotein oxidative modifications. The lipid parameter corrective capabilities of PG-ellagitannins have also been extensively reported to be significantly effective in reducing hyperlipidemia (TC, LDL-C, VLDL-C, and TAGs), while increasing plasma HDL-C concentrations and improving the TC/HDL-C and LDL-C/HDL-C ratios. The health benefits of pomegranate consumption seem to be acheived through the amelioration of adipose tissue endocrine function, fatty acid utilization, GLUT receptor expression, paraoxonase activity enhancement, and the modulation of PPAR and NF-κB. While the results from animal experiments are promising, human findings published in this field are inconsistent and are still limited in several aspects. The present review aims to discuss and provide a critical analysis of PG’s bioeffects on the components of metabolic syndrome, type-2 diabetes, obesity, and dyslipidemia, as well as on certain cardiovascular-related diseases. Additionally, a brief overview of the pharmacokinetic properties, safety, and bioavailability of PG-ellagitannins is included.

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EFFECT OF SENNA (Senna alexandrina Mill.) AND POMEGRANATE (Punica granatum L.) LEAVES EXTRACTS AND ITS FRACTIONS ON PRO-INFLAMMATORY CYTOKINES OF THE OBESE ZEBRAFISH (Danio rerio)

Cited by 6 publications

References 24 publications

Efek Hipoglikemia Formula Herbal Antidiabetes Pada Tikus Diabetes Yang Diinduksi Alloxan

Efek Hipoglikemia Formula Herbal Antidiabetes Pada Tikus Diabetes Yang Diinduksi Alloxan

Exploring Plants with Flowers: From Therapeutic Nutritional Benefits to Innovative Sustainable Uses

The Modulatory Bioeffects of Pomegranate (Punica granatum L.) Polyphenols on Metabolic Disorders: Understanding Their Preventive Role against Metabolic Syndrome

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