Effect of Septal Ablation on Regional Diastolic Dysfunction and Diastolic Asynchrony in Patients with Hypertrophic Obstructive Cardiomyopathy: A Follow‐Up Study Using Speckle Tracking Echocardiography

Abstract

Percutaneous transluminal septal myocardial ablation has a favorable effect on regional diastolic abnormalities and diastolic asynchrony, which may partly account for the persistent improvement in global LV diastolic function in HOCM patients after PTSMA.

Left Ventricular and Atrial Functions in Hypertrophic Cardiomyopathy Patients with Very High LVOT Gradient: A Speckle Tracking Echocardiographic Study

“…Conventional echocardiographic parameters such as LVEF may not help to detect subclinical LV dysfunction. STE may provide better information about myocardial mechanics in HCM patients and is feasible for evaluating LV dysfunction in these patients …”

“…STE may provide better information about myocardial mechanics in HCM patients and is feasible for evaluating LV dysfunction in these patients. [12][13][14][15] In this study, we evaluated the LV and LA functions of HCM patients with conventional M-mode, 2D, tissue Doppler, and 2DSTE echocardiography. We found that left ventricular dimensions were lower, wall thickness, mass, and atrial dimensions and volumes were significantly higher in HCM patients.…”

Septal reduction therapies in hypertrophic cardiomyopathy: comparison of surgical septal myectomy and alcohol septal ablation

“…The reported effects of ASA on diastolic dysfunction are heterogeneous. Some studies have demonstrated improvement in parameters of diastolic function following ASA [95][96][97][98], while another study showed no significant difference between diastolic assessment following ASA and myectomy when assessed 5 months post-procedurally [99]. At our institution, we have seen variable change in diastolic function, likely reflecting a balance of obstruction relief and intrinsic effect of the infarct itself [100].…”

Characteristics of Myocardial Postsystolic Shortening in Patients with Symptomatic Hypertrophic Obstructive Cardiomyopathy before and Half a Year after Alcohol Septal Ablation Assessed by Speckle Tracking Echocardiography

“…The selection criteria for PTSMA were as follows: the persistence of symptoms despite being administered the maximum tolerated dosage of medication; a left ventricular outflow tract (LVOT) gradient >50 mmHg at rest or >100 mmHg after provocation; accessible septal branches, particularly of the left anterior descending coronary artery; the absence of a significant intrinsic abnormality of the mitral valve; and other conditions for which cardiac surgery was indicated. PTSMA were performed as previously described [12]–[13]. PTSMA success was defined as an improvement in the New York Heart Association (NYHA) class and a reduction in the LVOT pressure gradient of 50% of the baseline.…”