Effect of Serotonin on the Immunoreactive Thyrotropin-Releasing Hormone Concentrations of the Rat Stomach

Kaneko, Hiroshi; Mitsuma, Terunori; Morise, Kimitomo; Uchida, Kiyoshi; Furusawa, Atsushi; Maeda, Yoshiaki; Nakada, Kouichi; Adachi, Kiyoshi

doi:10.1159/000200990

Digestion

1992

DOI: 10.1159/000200990

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Effect of Serotonin on the Immunoreactive Thyrotropin-Releasing Hormone Concentrations of the Rat Stomach

Hiroshi Kaneko

Terunori Mitsuma²,

Kimitomo Morise³

et al.

Abstract: The effects of serotonin and its related compounds on immunoreactive thyrotropin-releasing hormone (ir-TRH) concentrations of the rat stomach wall and gastric juice were studied. Either serotonin, cyproheptadine or GR38032F was injected intraperitoneally, and the rats were decapitated at various times after the injection. ir-TRH concentrations of the stomach wall and gastric juice were measured by radioimmunoassay, and gastric serotonin concentrations were measured by HPLC. ir-TRH concentrations of the stomach… Show more

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Cited by 6 publications

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“…Although intracisternal injection of TRH has been shown to exert the dual central effects of gastric cytoprotection and lesion formation on the basis of the balance between cytoprotective mechanisms and ulcerogenic factors (11), the relevance of TRH located peripherally in the stomach is poorly understood. Our recent studies showed that TRH was released from the gastric wall into the gastric juice in stress-(water immersion and cold restraint) or chemically induced experimental models of gastric mucosal lesions of the rat (6)(7)(8)(9)12). Under such experimental conditions TRH seemed to have ulcerogenic effects on the stomach by stimulating acid secretion in a paracrine manner.…”

mentioning

confidence: 99%

Intraluminal Thyrotropin-Releasing Hormone Affects Gastric Somatostatin and Acid Secretion through Its Specific Receptor in Rats

Nishio

Kusugami²,

Kaneko³

et al. 1999

Scandinavian Journal of Gastroenterology

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mentioning

confidence: 99%

Intraluminal Thyrotropin-Releasing Hormone Affects Gastric Somatostatin and Acid Secretion through Its Specific Receptor in Rats

Nishio

Kusugami²,

Kaneko³

et al. 1999

Scandinavian Journal of Gastroenterology

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Nizatidine accelerates gastric emptying of a solid meal in rats

et al. 1995

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Nizatidine, a new histamine-2-receptor antagonist, stimulates gastrointestinal motility in dogs and gastric emptying of liquids in rats. Effect of nizatidine on gastric emptying of a solid meal was investigated using a novel gastric emptying model in rats. Male Wistar rats (weighing 200-300 g) were supplied with powdered food containing 30 w/w% barium 14 hr before the beginning of the experiment and x-ray photography of rat stomach was taken under light ether anesthesia. Gastric emptying was assessed by percentage of a decrease in area 30 min after drug was injected intraperitoneally. There was a positive correlation between the area of the gastric outline and the weight of the gastric contents (r = 0.94, P < 0.01). Ether anesthesia itself did not affect gastric emptying. Nizatidine increased gastric emptying dose-dependently (emptied percentage; vehicle: 4.9 +/- 1.5%, 1 mg/kg: 7.2 +/- 0.4%, 3 mg/kg: 10.4 +/- 2.0%, 10 mg/kg: 16.7 +/- 4.9%, 30 mg/kg: 25.7 +/- 7.4%). N-Desmethyl nizatidine (NDM) also stimulated gastric emptying, but nizatidine S-oxide, cimetidine, an famotidine had no significant effects on gastric emptying. Nizatidine and neostigmine, but not NDM, at a subthreshold dose accelerated gastric emptying treated with a low dose of acetylcholine (0.1 mg/kg). Atropine (2 mg/kg, -30 min) did not modulate the gastroprokinetic action of nizatidine, but blocked that of NDM. These findings suggest that this noninvasive method may allow measurement of gastric emptying of solids accurately and that nizatidine and NDM facilitate gastric emptying probably mediated by a direct and/or an indirect (acetylcholinesterase inhibition) cholinergic mechanism.

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Effect of cold-restraint stress on immunoreactive thyrotropin-releasing hormone and immunoreactive somatostatin in the rat stomach

et al. 1995

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The effects of cold-restraint stress on immunoreactive thyrotropin-releasing hormone (ir-TRH) and immunoreactive somatostatin (ir-SOM) concentrations in the rat stomach were investigated. Rats immobilized with a spring-loaded metallic plate were placed in a room maintained at 4 degrees C for 1-3 h and then decapitated serially for investigation. Gastric ir-TRH and ir-SOM concentrations were measured by individual radioimmunoassays. Cold-restraint stress induced gastric mucosal lesions as well as a decrease of the ir-TRH concentration in the glandular stomach, an increase of the ir-TRH concentration in the gastric juice, and a decrease in gastric pH. In contrast, this stress caused an increase of ir-SOM in the glandular stomach and a decrease of ir-SOM in the gastric juice. However, cold or restraint stress alone did not induce gastric mucosal lesions or changes in gastric ir-TRH and ir-SOM concentrations or the gastric pH. To clarify the endocrine influence of peripheral TRH, pretreatment with thyroid hormone was performed to inhibit elevation of the serum TRH level during cold-restraint stress. Despite this pretreatment, cold-restraint stress still induced ulcer formation, along with changes in gastric ir-TRH and ir-SOM concentrations and gastric pH. These findings suggest that changes in gastric ir-TRH and ir-SOM concentrations may be closely related to ulcer formation due to cold-restraint, and that TRH may act in a paracrine manner in the stomach.

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Effect of Serotonin on the Immunoreactive Thyrotropin-Releasing Hormone Concentrations of the Rat Stomach

Cited by 6 publications

References 13 publications

Intraluminal Thyrotropin-Releasing Hormone Affects Gastric Somatostatin and Acid Secretion through Its Specific Receptor in Rats

Intraluminal Thyrotropin-Releasing Hormone Affects Gastric Somatostatin and Acid Secretion through Its Specific Receptor in Rats

Nizatidine accelerates gastric emptying of a solid meal in rats

Effect of cold-restraint stress on immunoreactive thyrotropin-releasing hormone and immunoreactive somatostatin in the rat stomach

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