Effect of serum 25-hydroxyvitamin D level on lung, breast, colorectal and prostate cancers: a nested case-control study

Abstract

Background: Published studies show that vitamin D deficiency is widespread and it has been suggested that it increases the risk of lung, breast, colorectal and prostate cancers. Aims: To investigate prospectively the effect of serum 25-hydroxyvitamin D (25(OH)D) level on lung, breast, colorectal and prostate cancers in people aged 30+ years. Methods: In this nested case-control study, the data and collected serum samples from a cohort study, the Balçova Heart Study, during 2007-09, were used. Additional data were collected using a questionnaire in the follow-up. We determined incident lung, breast, colorectal and prostate cancer cases during 2008 and 2013. Serum 25(OH)D levels of 606 persons (179 cases and 427 controls) from the Balçova Heart Study were measured. Odds ratio (OR) and 95% confidence interval (CI) were calculated using logistic regression analysis. Results: Serum 25(OH)D levels did not show a significant association with breast, colorectal and prostate cancers. There was an inverse association between 25(OH)D level and lung cancer risk, where the OR values for the first, second and third quartiles, compared with the fourth quartile (1.00), were 2.92 (

Circulating vitamin D levels and colorectal cancer risk: A meta-analysis and systematic review of case-control and prospective cohort studies

“…Studies using continuous risk per dose were excluded from the analyses, but we described their results within the text. Moreover, studies with other type of comparisons (e.g., bottom versus top; or middle versus top) were re-calculated (Acikgoz, Cimrin, and Ergor 2020;C. Garland, et al 1989;Jenab et al 2010;McCullough, et al 2019;Neuhouser et al 2012; Jos e M. Ord oñez- Mena et al 2016;Weinstein et al 2011;Wong et al 2014) in a highest versus lowest fashion using Jan Hamling et al methodology (Hamling et al 2008).…”

Research Progress on the Relationship between Vitamin D and Lung Cancer

“…Findings suggest a strong correlation between serum vitamin D levels and lung cancer risk. Some studies indicate that low serum vitamin D concentrations may increase the likelihood of developing lung cancer by over threefold, while no such association was observed with breast cancer, thyroid cancer, and other types [25]. A study on Chinese individuals revealed a correlation between low serum vitamin D levels and a higher incidence of lung cancer, particularly advanced non-small cell lung cancer [26].…”