Effect of serum fatty acid composition on coronary atherosclerosis in Japan

Hōjō, Nobumasa; Fukushima, Tetsuhito; Isobe, Akio; Gao, Tongqiang; Shiwaku, Kuninori; Ishida, Keiichiro; Ohta, Nobuhiro; Yamane, Yoshihiro

doi:10.1016/s0167-5273(98)00199-5

Cited by 12 publications

(4 citation statements)

References 29 publications

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“…Plasma EPA, DHA, and n-3 PUFA levels of the Koreans fell between those of the Japanese and Mongolians. The remarkably higher values for plasma n-3 PUFAs, particularly EPA and DHA, in the present study clearly reflect the differences in marine fish consumption among the three ethnic groups (28). Because the Mongolians showed the highest values for LNA levels, the Mongolian diet appears to have LNA in its soybean, canola flaxseed, and perilla seed oils, which convert to EPA and DHA in small amounts and can be substituted for fish oil (29).…”

Section: Discussionsupporting

confidence: 46%

Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians

Shiwaku

Hashimoto

Kitajima

et al. 2004

Journal of Lipid Research

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Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The hypotriglyceridemic effects of n-3 PUFAs have been confirmed in Caucasians, but the effect in Asians is less clear. Recent evidence indicates that stearoyl-CoA desaturase (SCD) activity induced with high-carbohydrate diets increases plasma triglyceride levels. We investigated the relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity, and n-3 PUFAs in 411 Japanese, 418 Korean, and 251 Mongolian adults. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower body mass index values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkably higher values for n-3 PUFAs than did the Mongolians. Multiple regression analysis showed that triglyceride levels had a great magnitude of correlation with the increases in 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFAs remained significant for the Mongolians. HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians.

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Section: Discussionsupporting

confidence: 46%

Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians

Shiwaku

Hashimoto

Kitajima

et al. 2004

Journal of Lipid Research

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“…However, the observational studies of stearic acid's association with CVD are inconclusive. (Table 2 ) Among retrospective studies, a Japanese case-control study of serum levels reported no association for stenosis [ 61 ], a Norwegian study found lower odds of MI [ 62 ], while a Costa Rican study of dietary intake found higher risk of MI [ 63 ] with higher intake of stearic acid. However, the results from the Costa Rican study should not be given much weight since retrospective self-report of dietary intakes are notoriously inaccurate and susceptible to reporting bias [ 64 ].…”

Section: Reviewmentioning

confidence: 99%

Chocolate and Prevention of Cardiovascular Disease: A Systematic Review

et al. 2006

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“…Thus, the level of muscle membrane n-3 LCPUFA may be a key indicator of metabolic health. There is increasing interest in using circulating levels of n-3 PUFA and LCPUFA as potential markers of insulin resistance and risk of coronary heart disease (22,23). For example, in a population-based case-control study in the United States, Siscovick et al (23) found that a red blood cell n-3 PUFA level of 5.0% of total FA was associated with a 70% reduction in the risk of primary cardiac arrest compared with a red blood cell n-3 PUFA level of 3.3% (22).…”

Section: Figmentioning

confidence: 99%

Relationships between the fatty acid composition of muscle and erythrocyte membrane phospholipid in young children and the effect of type of infant feeding

Baur

O’Connor

Pan

et al. 2000

Lipids

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Muscle membrane fatty acid (FA) composition is linked to insulin action. The aims of this study were to compare the FA composition of muscle and erythrocyte membrane phospholipid in young children; to investigate the effect of diet on these lipid compositions; and to investigate differential incorporation of FA into muscle, erythrocyte and adipose tissue membrane phospholipid, and adipose tissue triglyceride. Skeletal muscle biopsies and fasting blood samples were taken from 61 normally nourished children (45 males and 16 females), less than 2 yr old (means +/- SE, 0.80 +/- 0.06 yr), undergoing elective surgery. Adipose tissue samples were taken from 15 children. There were significant positive correlations between muscle and erythrocyte docosahexaenoic acid (DHA) (r = 0.44, P < 0.0001), total n-3 polyunsaturated fatty acids (PUFA) (r = 0.39, P = 0.002), and the n-6/n-3 PUFA ratio (r = 0.39, P = 0.002). Adipose tissue triglyceride had lower levels of long-chain PUFA, especially DHA, than muscle and erythrocytes (0.46 +/- 0.18% vs. 2.44 +/- 0.26% and 3.17 +/- 0.27%). Breast-fed infants had higher levels of DHA than an age-matched group of formula-fed infants in both muscle (3.91 +/- 0.21% vs. 1.94 +/- 0.18%) and erythrocytes (3.81 +/- 0.40% vs. 2.65 +/- 0.23%). The results of this study show that (i) erythrocyte FA composition is a reasonable index of muscle DHA, total n-3 PUFA, and the n-6/n-3 PUFA ratio; (ii) breast feeding has a potent effect on the FA composition of all these tissues; and (iii) there is a wide range in long-chain PUFA levels in muscle, erythrocytes, and adipose tissue.

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Effect of serum fatty acid composition on coronary atherosclerosis in Japan

Cited by 12 publications

References 29 publications

Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians

Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians

Chocolate and Prevention of Cardiovascular Disease: A Systematic Review

Relationships between the fatty acid composition of muscle and erythrocyte membrane phospholipid in young children and the effect of type of infant feeding

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