Effect of serum lactate dehydrogenase-to-albumin ratio (LAR) on the short-term outcomes and long-term prognosis of colorectal cancer after radical surgery

Abstract

Background Whether serum lactate dehydrogenase-to-albumin ratio (LAR) influenced the outcomes of colorectal cancer (CRC) patients after radical surgery remained unclear. Therefore, this study sought to examine how LAR influences the short-term and long-term outcomes of CRC patients who have undergone radical surgery. Methods This study retrospectively included CRC patients who underwent radical resection between January 2011 and January 2020. We compared short-term outcomes, as well as overall survival (OS) and disease-free survival (DFS), among various groups. Both univariate and multivariate logistic regression analyses were utilized to pinpoint independent risk factors associated with overall complications and major complications. Moreover, Cox regression analysis were conducted for OS and DFS. Odds ratio (OR) and Hazard ratio (HR) were adjusted. Results This study encompassed a cohort of 3868 patients. 3440 patients were in the low LAR group and 428 patients constituted the high LAR group. In the high LAR group, patients experienced significantly longer operative times (p < 0.01), larger intraoperative blood loss (p < 0.01), and extended postoperative hospital stays (p < 0.01). Additionally, the incidence of both overall complications (p < 0.01) and major complications (p < 0.01) was higher in the high LAR group compared to the low LAR group. Furthermore, LAR was emerged as an independent prognostic factor for overall complications [OR/95% CI: (1.555/1.237 to 1.954), p < 0.01] and major complications [OR/95% CI: (2.178/1.279 to 3.707), p < 0.01]. As for long-term survival, the high LAR group had worse OS in stage II (p < 0.01) and stage III (p < 0.01). In both stage II (p < 0.01) and stage III (p < 0.01), the high LAR group exhibited poorer DFS. Additionally, according to Cox regression analysis, LAR was identified as an independent predictor for both OS [HR/95% CI: (1.930/1.554 to 2.398), p < 0.01] and DFS [HR/95% CI: (1.750/1.427 to 2.146), p < 0.01]. Conclusion LAR emerged as an independent predictor not only for overall complications and major complications but also for both OS and DFS, highlighting its significance and deserving the attention of surgeons.

Lactate dehydrogenase‐to‐albumin ratio: A superior inflammatory marker for predicting contrast‐associated acute kidney injury after percutaneous coronary intervention

“…Furthermore, several inflammatory markers constructed based on serum parameters, such as systemic immune‐inflammation index (SII), neutrophil‐to‐lymphocyte ratio (NLR), and C‐reactive protein (CRP), have been extensively validated for their close associations with various inflammation‐associated disorders, including CA‐AKI 6–9 . Recently, a novel serum biomarker, known as the lactate dehydrogenase‐to‐albumin ratio (LAR), has been introduced to assess the inflammatory status in patients with various malignancies, and it has been confirmed to be closely linked to adverse prognosis 10,11 . Nevertheless, to date, there has been limited research into the potential association between LAR and CA‐AKI.…”

“… 6 , 7 , 8 , 9 Recently, a novel serum biomarker, known as the lactate dehydrogenase‐to‐albumin ratio (LAR), has been introduced to assess the inflammatory status in patients with various malignancies, and it has been confirmed to be closely linked to adverse prognosis. 10 , 11 Nevertheless, to date, there has been limited research into the potential association between LAR and CA‐AKI. Therefore, the present study aimed to investigate the predictive value of LAR for CA‐AKI as well as all‐cause mortality among patients treated with elective PCI.…”

The relationship between lactate dehydrogenase to albumin ratio and all-cause mortality during ICU stays in patients with sepsis: A retrospective cohort study with propensity score matching

“…The LDH to albumin (LDH/ALB) ratio is emerging as a novel biomarker of inflammation. While previous research on LDH/ALB ratio has been centered around malignant tumors [ 12 , 13 ], recent evidence suggests its relevance to the prognosis of patients with lower respiratory tract infection [ 14 ] and severe infection requiring monitoring [ 15 ]. A specific study explored the correlation between the LDH/ALB ratio and prognosis in patients with sepsis-associated acute kidney injury, revealing that an elevated LDH/ALB ratio was linked to increased mortality rates at 28-day, 90-day, and during hospitalization [ 16 ].…”