2005
DOI: 10.1097/01.shk.0000172366.73881.c7
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Effect of Sesame Oil on Oxidative-Stress-Associated Renal Injury in Endotoxemic Rats: Involvement of Nitric Oxide and Proinflammatory Cytokines

Abstract: This study aimed to investigate the effect of sesame oil on oxidative stress-associated renal injury induced by lipopolysaccharide in rats. The effects of sesame oil on renal injury, oxidative stress, hydroxyl radical, superoxide anion, nitric oxide, and proinflammatory cytokines were assessed after a lipopolysaccharide challenge. Sesame oil attenuated lipopolysaccharide-induced renal injury, decreased lipid peroxidation, increased the activities of superoxide dismutase, catalase, and glutathione peroxidase, r… Show more

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Cited by 74 publications
(48 citation statements)
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“…Sesame oil and its lignan, sesamol are potent antioxidants and antiinflammatory agents [5]. Sesamin from sesame seeds has also been reported to possess in vivo hypo-cholesterolemic activity and suppressive attributes activity against chemically induced cancer, lipopolysaccharide and human low-density lipoprotein (LDL).…”
Section: Introductionmentioning
confidence: 99%
“…Sesame oil and its lignan, sesamol are potent antioxidants and antiinflammatory agents [5]. Sesamin from sesame seeds has also been reported to possess in vivo hypo-cholesterolemic activity and suppressive attributes activity against chemically induced cancer, lipopolysaccharide and human low-density lipoprotein (LDL).…”
Section: Introductionmentioning
confidence: 99%
“…Lignans comprise sesamin, sesamolin, and a small amount of sesamol (Namiki, 1995). They have multiple physiological functions, such as decreasing blood lipids (Hirata et al, 1996) and arachidonic acid levels , increasing antioxidative ability (Ghafoorunissa, 2004) and γ-tocopherol bioavailability (Lemcke-Norojarvi et al, 2001) and providing anti-inflammatory function (Hsu et al, 2005). Some sesame lignans (e.g., sesamin) are converted to the mammalian lignans, which may exert weak estrogenic and antiestrogenic activities (Peñalvo et al, 2005;Wu et al, 2006).…”
Section: Sesame Oilmentioning
confidence: 99%
“…The SEO-containing diets reduced glycemia, blood cholesterol and triglyceride levels and prevented pathological problems like formation of hepatic steatosis, and renal sepsis caused by lipopolysaccharide (LPS) (HSU et al, 2005;GUIMARÃES & MACEDO, 2013;PERIASAMY et al, 2014). Moreover, the lignans contained in SEO such as sesamin, episamin and sesamolin, may promote the formation of fatty acids as the DHA, from the desaturation and elongation of LNA (TRATTNER et al, 2008a;KÖSE & YILDIZ, 2013).…”
Section: Introductionmentioning
confidence: 99%