Effect of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on reproductive system

Wang, Nengzhuang; Qin, Lanfang; Ma, Ling; Yan, Hongli

doi:10.1016/j.scr.2021.102189

Cited by 20 publications

(15 citation statements)

References 84 publications

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“…Since the emergence of the SARS-CoV-2 infection in December 2019, it has rapidly spread across all over the world. Additionally, it has been demonstrated that SARS-CoV-2 infection not only damage to respiratory system, but other organs of human, such as heart, liver, oesophagus, kidney, bladder, and ileum [143]. As mentioned above, ACE2, the functional receptor for SARS-CoV-2, modulates the cleavage of Ang II and Ang 1-7.…”

Section: Covid-19 On Reproductive Systemmentioning

confidence: 92%

COVID-19: systemic pathology and its implications for therapy

Shen¹,

Li²,

Zhang³

et al. 2022

Int. J. Biol. Sci.

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Responding to the coronavirus disease 2019 (COVID-19) pandemic has been an unexpected and unprecedented global challenge for humanity in this century. During this crisis, specialists from the laboratories and frontline clinical personnel have made great efforts to prevent and treat COVID-19 by revealing the molecular biological characteristics and epidemic characteristics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, SARS-CoV-2 has severe consequences for public health, including human respiratory system, immune system, blood circulation system, nervous system, motor system, urinary system, reproductive system and digestive system. In the review, we summarize the physiological and pathological damage of SARS-CoV-2 to these systems and its molecular mechanisms followed by clinical manifestation. Concurrently, the prevention and treatment strategies of COVID-19 will be discussed in preclinical and clinical studies. With constantly unfolding and expanding scientific understanding about COVID-19, the updated information can help applied researchers understand the disease to build potential antiviral drugs or vaccines, and formulate creative therapeutic ideas for combating COVID-19 at speed.

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Section: Covid-19 On Reproductive Systemmentioning

confidence: 92%

COVID-19: systemic pathology and its implications for therapy

Shen¹,

Li²,

Zhang³

et al. 2022

Int. J. Biol. Sci.

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“…In guinea pigs, which seem to be similar to humans with regards to ACE2 and angiotensin 1-7 (Ang 1-7) expression, ACE2 expression played a critical role in the decidualization process, trophoblastic invasion, and also in regulating placental blood flow [ 81 ]. Based on previous reports researchers have maintained that human fertility might be compromised by SARS-CoV-2 infections, especially in males, though the impact of SARS-CoV-2 in human fertility is still controversial and further studies are needed [ [124] , [125] , [126] , [127] , [128] , [129] , [130] , [131] , [132] , [133] ]. It has been recommended that non-pregnant, fertile women that have recently acquired SARS-CoV-2 infections have a close follow-up consultation until more evidence is available [ 119 ].…”

Section: Sars-cov-2 Zika and Mycoplasma Presentation During Pregnancy And Its Pathophysiological And Molecular Correlationsmentioning

confidence: 99%

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Ferreira

Blasina

Rey

et al. 2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.

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“…Also, TMPRSS2 RNA has been noticed in all reproductive organs but it demonstrated significant higher expression in the male tissues [ 23 , 24 ]. It seems that SARS-CoV-2 is unlikely to infect ovaries or interrupt oogenesis [ 25 ]. Abhari et al researched the number of ACE transcripts in the endometrium and the expression of the protein form.…”

Section: Sars-cov-2 In Female Reproductive Organsmentioning

confidence: 99%

The Impact of SARS-CoV-2 Infection on Fertility and Female and Male Reproductive Systems

Markiewicz-Gospodarek

Wdowiak

Czeczelewski

et al. 2021

JCM

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains a huge challenge for contemporary healthcare systems. Apart from widely reported acute respiratory distress syndrome (ARDS), the virus affects many other systems inducing a vast number of symptoms such as gastrointestinal, neurological, dermatological, cardiovascular, and many more. Currently it has also been hypothesized that the virus might affect female and male reproductive systems; SARS-CoV-2 infection could also have a role in potential disturbances to human fertility. In this article, we aimed to review the latest literature regarding the potential effects of SARS-CoV-2 infection on female and male reproductive systems as well as fertility, in general.

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Effect of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on reproductive system

Cited by 20 publications

References 84 publications

COVID-19: systemic pathology and its implications for therapy

COVID-19: systemic pathology and its implications for therapy

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

The Impact of SARS-CoV-2 Infection on Fertility and Female and Male Reproductive Systems

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