Effect of Sex Hormones on Eosinophilic Inflammation in Nasal Mucosa

Hamano, Nanako; Terada, Nobuhisa; Maesako, Ken-ichi; Numata, Tsutomu; Konno, Akiyoshi

doi:10.2500/108854198778557773

Cited by 123 publications

(82 citation statements)

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“…Few studies have evaluated the relationship between eosinophils and sex hormones. It seems that b-oestradiol significantly enhances eosinophil adhesion to human mucosal microvascular endothelial cells and their degranulation [42,43].…”

Section: Discussionmentioning

confidence: 99%

Importance of concomitant local and systemic eosinophilia in uncontrolled asthma

et al. 2014

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Systemic and airway eosinophilia are recognised features of asthma. There are, however, patients who exhibit discordance between local and systemic eosinophilia. In this study, we sought to determine the prevalence and characteristics of patients with concordant and discordant systemic and bronchial eosinophilia.We conducted a retrospective study on 508 asthmatics with successful sputum induction. We assessed the relationship between blood and sputum eosinophils by breaking down the population into four groups according to blood (o400 cells per mm 3 ) and sputum (o3%) eosinophils. Then, we prospectively reassessed the link between eosinophils and asthma control (Asthma Control Questionnaire (ACQ)) and exacerbation rate in a new cohort of 250 matched asthmatics.In our retrospective cohort, asthmatics without eosinophilic inflammation were the largest group (49%). The group with isolated sputum eosinophilia (25%) was, compared with noneosinophilic asthma, associated with lower forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity ratio and higher bronchial hyperresponsiveness and exhaled nitric oxide fraction (FeNO). Asthmatics exhibiting isolated systemic eosinophilia (7%) had similar characteristics as noneosinophilic asthmatics. The group with concordant systemic and airway eosinophilia (19%) showed remarkable male predominance, and had the lowest airway calibre, asthma control and quality of life, and the highest bronchial hyperresponsiveness, FeNO and exacerbation rate. The prospective cohort confirmed the different subgroup proportions and the higher ACQ and exacerbation rates in cases of diffuse eosinophilia compared with noneosinophilic asthmatics.Concomitant systemic and bronchial eosinophilic inflammation contribute to poor asthma control.@ERSpublications Concomitant systemic and bronchial eosinophilic inflammation contributes to poor asthma control

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Section: Discussionmentioning

confidence: 99%

Importance of concomitant local and systemic eosinophilia in uncontrolled asthma

et al. 2014

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“…(132). Similarly, a combination of estrogen and progesterone was able to significantly enhance human eosinophil degranulation (56). Other studies have found that estrogen treatment of eosinophils was capable of enhancing their adhesion to human mucosal microvascular endothelial cells, whereas testosterone reduced this effect (56).…”

Section: Eosinophilsmentioning

confidence: 99%

Sex-Associated Hormones and Immunity to Protozoan Parasites

2001

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Numerous epidemiological and clinical studies have noted differences in the incidence and severity of parasitic diseases between males and females. Although in some instances this may be due to gender-associated differences in behavior, there is overwhelming evidence that sex-associated hormones can also modulate immune responses and consequently directly influence the outcome of parasitic infection. Animal models of disease can often recreate the gender-dependent differences observed in humans, and the role of sex-associated hormones can be confirmed by experimentally altering their levels. Under normal circumstances, levels of sex hormones not only differ between males and females but vary according to age. Furthermore, not only are females of reproductive age subject to the regular hormonal cycles which control ovulation, they are also exposed to dramatically altered levels during pregnancy. It is thus not surprising that the severity of many diseases, including those caused by parasites, has been shown to be affected by one or more of these circumstances. In addition, infection with many pathogens has been shown to have an adverse influence on pregnancy. In this article we review the impact of sex-associated hormones on the immune system and the development and maintenance of immunity to the intracellular protozoan parasites Toxoplasma gondii, Plasmodium spp., and Leishmania spp

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“…Therefore, a modulation of the allergic immune response by hormones as well as socio-cultural factors may contribute to gender differences encountered [8,21,34] .…”

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confidence: 99%

“…Additionally, female hormones increase the expression of histamine receptors on inflammatory cells and may promote eosinophilic inflammation [34] .…”

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confidence: 99%

Food Allergy: An Increasing Problem for the Elderly

Möhrenschlager

Ring

2010

Gerontology

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As populations become older all over the world, allergic reactions in elderly persons will be encountered more often in the future. Up to now, there has been much more literature on allergy prevalence in childhood than on allergy diseases in adults. As a challenge to epidemiology, allergic disorders in elderly persons may be masked by various symptoms corresponding with a general age-induced decline of physiological functions, including vitamin D deficiency and gastric pH increase. How much structural and functional changes (e.g. low calcitriol level) or effects caused by drugs (e.g. acid-suppression medications) in addition to immunological alterations encountered at old age are responsible for this development is a matter of debate. In the years ahead, the problem of allergy in adulthood and especially in the elderly will become more pronounced.

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Effect of Sex Hormones on Eosinophilic Inflammation in Nasal Mucosa

Cited by 123 publications

References 0 publications

Importance of concomitant local and systemic eosinophilia in uncontrolled asthma

Importance of concomitant local and systemic eosinophilia in uncontrolled asthma

Sex-Associated Hormones and Immunity to Protozoan Parasites

Food Allergy: An Increasing Problem for the Elderly

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