Effect of short- and long-term strength exercise on cardiac oxidative stress and performance in rat

Ahmadiasl, Nasser; Najafipour, Hamid; Soufi, Farhad Ghadiri; Jafari, Afshar

doi:10.1007/s13105-011-0125-z

Cited by 19 publications

(18 citation statements)

References 31 publications

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“…Recent studies reported that recurring high dose AAS administration and physical training in mice produce significant increase in HW. (8,36) Both groups had significantly higher HW/BW ratio than control and non significantly higher than exercise-trained group. Riezzo et al (27) observed that exogenous AAS administration induced cardiac hypertrophy in vitro and in vivo, and when combined with exercise, these steroids change exercise-induced physiological cardiac hypertrophy to pathophysiological cardiac hypertrophy.…”

Section: Discussionmentioning

confidence: 86%

Effect of Exercise Training and Anabolic Androgenic Steroids on Hemodynamics , Glycogen Content , Angiogenesis and Apoptosis of Cardiac Muscle in Adult Male Rats

Hassan¹,

Kamal²

2013

IJHS

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Abstract:Objectives: To investigate the effects of exercise training and anabolic androgenic steroids (AAS) on hemodynamics, glycogen content, angiogenesis, apoptosis and histology of cardiac muscle.Methods: Forty rats were divided into 4 groups; control, steroid, exercise-trained and exercise-trained plus steroid groups. The exercise-trained and trained plus steroid groups, after one week of water adaptation, were exercised by jumping into water for 5 weeks. The steroid and trained plus steroid groups received nandrolone decanoate, for 5 weeks. Systolic blood pressure and heart rate (HR) were monitored weekly. Heart weight / body weight ratio (HW/BW ratio) were determined. Serum testosterone, vascular endothelial growth factor (VEGF), cardiac caspase-3 activity and glycogen content were measured.Results: Compared with control, the steroid group had significantly higher blood pressure, HR, sympathetic nerve activity, testosterone level, HW/BW and cardiac caspase-3 activity. Histological examination revealed apoptotic changes and hypertrophy of cardiomyocytes. In exercise-trained group, cardiac glycogen, VEGF and testosterone levels were significantly higher while HR was significantly lower than control. HW/BW was more than control confirmed by hypertrophy of cardiomyocytes with angiogenesis on histological examination. Trained plus steroid group, had no change in HR, with higher blood pressure and HW/BW than control, cardiac glycogen and serum VEGF were higher than control but lower than exercisetrained group. Histological examination showed hypertrophy of cardiomyoctes with mild angiogenesis rather than apoptosis. Conclusion:When exercise is augmented with AAS, exercise-associated cardiac benefits may not be fully gained with potential cardiac risk from AAS if used alone or combined with exercise.

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Section: Discussionmentioning

confidence: 86%

Effect of Exercise Training and Anabolic Androgenic Steroids on Hemodynamics , Glycogen Content , Angiogenesis and Apoptosis of Cardiac Muscle in Adult Male Rats

Hassan¹,

Kamal²

2013

IJHS

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“…(SOD). In contrast, Ahmadiasl et al [24] found no improvement in the antioxidant capacity of rats subjected to jumping protocol after 4 and 12 weeks of training at rest. However, there was no increase in oxidative parameters after acute exercise, showing that this type of training ameliorates the deleterious effects of acute exercise in relation to oxidative stress.…”

Section: Some Authors Have Observed That the Rt Promoted Adaptation Imentioning

confidence: 90%

“…showing lower levels of lipid peroxidation [22] and increased activity of superoxide dismutase and catalase enzyme in erythrocytes [21]. In animals, the existing studies verified the effect of the RT in skeletal muscle [23], cardiac [24] and liver [18]. Murlasits et al [23] have reported that RT three times a week promotes a 66% increase in the expression of the enzyme superoxide dismutase DOI: 10.4236/oalib.1104411 2 Open Access Library Journal M. Costa-Junior et al…”

Section: Some Authors Have Observed That the Rt Promoted Adaptation Imentioning

confidence: 96%

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Different Protocols of Physical Training: Effect on Markers of Oxidative Stress in Erythrocytes in Rats

Costa-Junior¹,

Barbosa-Resende²,

Araújo³

et al. 2018

OALib

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The imbalance between oxidant molecules and antioxidant agents is characterized as oxidative stress (OS) and may lead to severe damage to the organism. In contrast, the physical training of aerobic and resistive character promotes increases of the antioxidant response, resulting in a balance and/or minimizing damage. Therefore, the objective of the study is to verify the effect of aerobic training, resistive training and concurrent training on oxidative stress of Wistar rats. Methods: To perform the experiment, 40 Wistar rats were subjected to eight weeks of training. The animals were distributed into 4 different groups: control, aerobic, resistive and concurrent (combination of aerobic and resistive protocols in the same section) an h/day, five days/week, for eight weeks. At the end of the experimental period: the antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase), biomarkers of oxidative stress (TBARs and H 2 O 2) as well as the activity of reduced and oxidized glutathione were analyzed. Results: Regarding the markers, TBARs and H 2 O 2 trainings were not effective in promoting significant reduction. In contrast, the three training protocols caused an increase in SOD and GSH-GPx enzymes. Conclusion: Therefore, we concluded that both training protocols promoted benefit to the organism, because they caused the increase of antioxidant enzymes without disturbance in the pro-oxidant markers.

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“…A HSD is a major cause of hypertension, and it accelerates the secondary aging process and can lead to premature death (Samadian et al, 2016). Long-term exercise results in a number of physiological adaptations such as an increase angiogenesis and antioxidant ability that improves muscle performance and enhances the resistance of the muscle to fatigue (Ahmadiasl et al, 2012;Petersen and Greene, 2008). However, a HSD can impair skeletal muscle performance by inhibiting its angiogenesis and increasing oxidative stress (Bernardi et al, 2012;Lenda and Boegehold, 2002;Li et al, 2018;Petersen and Greene, 2008).…”

Section: Introductionmentioning

confidence: 99%

Endurance exercise protects agingDrosophilafrom high-salt diet(HSD)-induced climbing capacity decline and lifespan decrease by enhancing antioxidant capacity

et al. 2020

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A high-salt diet (HSD) is a major cause of many chronic and agerelated defects such as myocardial hypertrophy, locomotor impairment and mortality. Exercise training can efficiently prevent and treat many chronic and age-related diseases. However, it remains unclear whether endurance exercise can resist HSDinduced impairment of climbing capacity and longevity in aging individuals. In our study, flies were given exercise training and fed a HSD from 1-week old to 5-weeks old. Overexpression or knockdown of salt and dFOXO were built by UAS/Gal4 system. The results showed that a HSD, salt gene overexpression and dFOXO knockdown significantly reduced climbing endurance, climbing index, survival, dFOXO expression and SOD activity level, and increased malondialdehyde level in aging flies. Inversely, in a HSD aging flies, endurance exercise and dFOXO overexpression significantly increased their climbing ability, lifespan and antioxidant capacity, but they did not significantly change the salt gene expression. Overall, current results indicated that a HSD accelerated the age-related decline of climbing capacity and mortality via upregulating salt expression and inhibiting the dFOXO/SOD pathway. Increased dFOXO/SOD pathway activity played a key role in mediating endurance exercise resistance to the low salt tolerance-induced impairment of climbing capacity and longevity in aging Drosophila.

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Effect of short- and long-term strength exercise on cardiac oxidative stress and performance in rat

Cited by 19 publications

References 31 publications

Effect of Exercise Training and Anabolic Androgenic Steroids on Hemodynamics , Glycogen Content , Angiogenesis and Apoptosis of Cardiac Muscle in Adult Male Rats

Effect of Exercise Training and Anabolic Androgenic Steroids on Hemodynamics , Glycogen Content , Angiogenesis and Apoptosis of Cardiac Muscle in Adult Male Rats

Different Protocols of Physical Training: Effect on Markers of Oxidative Stress in Erythrocytes in Rats

Endurance exercise protects agingDrosophilafrom high-salt diet(HSD)-induced climbing capacity decline and lifespan decrease by enhancing antioxidant capacity

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