Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats

Gonzales, Carla; Rubio, Julio; Gasco, Manuel; Nieto, Jessica; Yucra, Sandra; Gonzáles, Gustavo F.

doi:10.1016/j.jep.2005.08.035

Cited by 121 publications

(147 citation statements)

References 21 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…The extracts caused non-significant changes in the body weight of rats after treatment for 50 days, this could be due to the absence of androgenic properties in this plant, since it has been reported that androgens possess anabolic activities (Johnson and Everitt, 1988) similar report was given by Gonzales et al (2006) in rats treated with Lepidium meyenii extracts.…”

Section: Discussionmentioning

confidence: 55%

Effects Of Crude Extracts Of Portulaca Oleracea On Male Reproductive Functions In Albino Rats

Oyedeji¹,

Bolarinwa²

2013

IOSR-JPBS

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 55%

Effects Of Crude Extracts Of Portulaca Oleracea On Male Reproductive Functions In Albino Rats

Oyedeji¹,

Bolarinwa²

2013

IOSR-JPBS

View full text Add to dashboard Cite

show abstract

“…The plant voucher (53/BFAR/020307) was deposited at the department. Next, the aqueous extract was prepared by using a traditional method, as suggested by Gonzales et al (2006) with modification. The sanrego stems were washed, dried, and powdered.…”

Section: Collection Of Plant Materials and Preparation Of Aqueous Extractmentioning

confidence: 99%

Effects of Lunasia amara Blanco (Sanrego) on Male Fertility: A Preliminary Study on Sperm Proteomic Analysis

Luthfi

Kamalrudin

et al. 2017

J App Pharm Sci

View full text Add to dashboard Cite

Lunasia amara Blanco or sanrego has long been applied as a pro-fertility agent in folk medicine and it has also been scientifically proven to improve sperm quality in rats. Nevertheless, little is known about the underlying molecular mechanism of improved sperm function upon treatment with sanrego. As such, this study looked into the potential proteomic changes in sperm treated with 60 mg/kg body weight sanrego aqueous extract, in comparison to control. The sperm proteins were subjected to proteomic analysis using 2-D SDS PAGE and MALDI-TOF. The comparison of the sperm protein profiles between treated and control rats revealed two downregulated proteins (cenexin-1 and GLUL) and 11 upregulated proteins (Eno1,PGK2,F1-ATP synthase, FO-ATP synthase, LDHC, GLUL1, ODF2, Sp17, asparaginase, DNAJB13, and tubulin) in treated rats. These proteins have been identified to be mainly involved in energy metabolism, sperm motility, amino acid metabolism, and cell signalling. This improved sperm function in sanrego-treated rats may, thus, be a direct result of proteomic changes, as discovered in this present study.

show abstract

“…Initial research has focussed on a possible role for Maca in improving male fertility [7][8][9][10][11][12][13][14] with emerging evidence that Maca may improve sperm production and quality 7 . Although few studies have as yet examined the effect of Maca in women, data from oophorectomized rats, suggests that Maca can improve bone mass and restore trabecular network in the lumbar vertebrae, findings relevant to the high risk of osteoporosis many women face after menopause 15 .…”

Section: Introductionmentioning

confidence: 99%

“…The possibility of estrogenic effects is based on the fact that Maca contains the phytoestrogen β-sitosterol 13 . Several studies, however have been unable to detect in vivo estrogenic effects 9,10,13 , although one study has reported that Maca extracts promote proliferation of MCF-7 cells, an estrogen receptor positive human breast cancer cell line 16 . Alkaloids, isothiocynates and glucosinolates are also potential active constituents of Maca 15 .…”

Section: Introductionmentioning

confidence: 99%

Maca reduces blood pressure and depression, in a pilot study in postmenopausal women

et al. 2014

View full text Add to dashboard Cite

Objective: Lepidium meyenii (Maca), a herbaceous plant, has been used for centuries for its fertility enhancing and aphrodisiac properties. In an Australian study, Maca improved anxiety and depressive scores. The effects of Maca on hormones, lipids, glucose, serum cytokines, blood pressure, menopausal symptoms and general well-being in Chinese postmenopausal women were evaluated Methods: A randomized, double-blind, placebo-controlled crossover study was conducted in 29 postmenopausal Hong Kong Chinese women. They received 3.3 g/day of Maca or placebo for 6 weeks each, in either order, over 12 weeks. At baseline, week 6 and week 12, estradiol, follicle stimulating hormone (FSH), sex hormone binding globulin (SHBG), thyroid stimulating hormone (TSH), full lipid profiles, glucose and serum cytokines, were measured. The Greene Climacteric, SF-36v2, Women's Health Questionnaire and Utian quality of life, scales were used to assess the severity of menopausal symptoms and health related quality of life.Results: There were no differences in estradiol, FSH, TSH, SHBG, glucose, lipid profiles and serum cytokines amongst those who received Maca as compared to placebo group, however, a significant decrease in both systolic and diastolic blood pressure was apparent after Maca treatment. The Greene Climacteric Scale revealed lower scores in the areas of psychological symptoms, including anxiety and depression following Maca. SF-36v2 showed stronger improvement in general and mental health when compared to baseline, whilst the women's health questionnaire showed improvement in depression and anxiety symptoms following Maca consumption. The Utian quality of life scoring did not show any differences in all domains tested.Conclusions: Maca does not exert hormonal or immune biological action in the small cohort of patients studies, however, it appears to reduce symptoms of depression and improve diastolic blood pressure in Chinese postmenopausal women. Although results are comparable to previous similar published studies in postmenopausal women, there might be a cultural difference among the Chinese postmenopausal women in terms of symptom reporting.

show abstract

Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats

Cited by 121 publications

References 21 publications

Effects Of Crude Extracts Of Portulaca Oleracea On Male Reproductive Functions In Albino Rats

Effects Of Crude Extracts Of Portulaca Oleracea On Male Reproductive Functions In Albino Rats

Effects of Lunasia amara Blanco (Sanrego) on Male Fertility: A Preliminary Study on Sperm Proteomic Analysis

Maca reduces blood pressure and depression, in a pilot study in postmenopausal women

Contact Info

Product

Resources

About