Effect of Short Term C PAP Therapy in Obstructive Sleep Apnea Patients with Metabolic Syndrome

Kanimozhi, S; Chilukuri, B.; Saravanan, A; Ravindran, Krishnan

doi:10.7860/jcdr/2015/13301.5859

Cited by 7 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Collectively, these concurrent pathophysiological circumstances promote insulin resistance, glucose intolerance, and eventually T2D (Doumit & Prasad, 2016 ). Currently, OSA therapy includes positive airway pressure (PAP) treatment, which resolves breathing events but modestly improves metabolic health (Kanimozhi et al., 2015 ; Sharma et al., 2011 ). As such, there is a critical need to identify treatments that improve glycemic control in patients with OSA.…”

Section: Introductionmentioning

confidence: 99%

Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial

Zunica,

Heintz,

Dantas

et al. 2024

Physiological Reports

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) is associated with increased risk for diabetes, and standard treatment with positive airway pressure (PAP) device shows inconsistent effects on glucose metabolism. Metformin is known to treat and prevent diabetes, but its effects on skeletal muscle mitochondrial function are not completely understood. Here, we evaluate the effects of metformin on glucose metabolism and skeletal muscle mitochondrial function in patients with OSA. Sixteen adults with obesity (50.9 ± 6.7 years, BMI: 36.5 ± 2.9 kg/m2) and moderate‐to‐severe OSA were provided with PAP treatment and randomized to 3 months of placebo (n = 8) or metformin (n = 8) treatment in a double‐blind parallel‐group design. Whole body glucose metabolism was determined by oral glucose tolerance test. A skeletal muscle biopsy was obtained to evaluate mitochondrial respiratory capacity and expression of proteins related to mitochondrial dynamics and energy metabolism. Whole body insulin‐sensitivity (Matsuda index) did not change in metformin or placebo treated groups. However, metformin treatment prevented increases in insulin release relative to placebo during follow‐up. Insulin area under the curve (AUC) and insulin to glucose AUC ratio increased in placebo but remained unchanged with metformin. Furthermore, metformin treatment improved skeletal muscle mitochondrial respiratory capacity and dynamics relative to placebo. Metformin treatment prevented the decline in whole body glucose homeostasis and skeletal muscle mitochondrial function in patients with moderate to severe OSA. Patients with OSA may benefit from the addition of metformin to prevent diabetes.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial

Zunica,

Heintz,

Dantas

et al. 2024

Physiological Reports

View full text Add to dashboard Cite

show abstract

Use of CPAP in patients with obstructive sleep apnea admitted to the general ward: effect on length of stay and readmission rate

2016

View full text Add to dashboard Cite

The majority of patients who are on domiciliary CPAP therapy were receiving CPAP therapy while admitted to the general medical ward of a tertiary care academic hospital. Presence of comorbid conditions such as obesity and certain cardiovascular diseases may have increased the likelihood of prescribing CPAP therapy while in the hospital. In-hospital CPAP therapy did not appear to significantly influence short-term outcomes such as hospital LOS, readmission rate, or time-to-readmission.

show abstract

Beyond heart health: Consequences of obstructive sleep apnea

Walia

2019

CCJM

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) is a serious condition associated with impaired quality of life, depression, drowsy driving and motor vehicle accidents, metabolic disease, and cognitive decline. The mechanisms accounting for OSA and metabolic disease include hypoxia, sleep fragmentation, and systemic infl ammation. OSA appears to advance cognitive decline, and the relationship between the 2 conditions may be bidirectional. Treatment of patients with continuous positive air pressure therapy improves many of the impaired outcomes associated with OSA. Greater awareness, screening, and treatment of patients with OSA can reduce the negative consequences associated with OSA.

show abstract

Effect of Short Term C PAP Therapy in Obstructive Sleep Apnea Patients with Metabolic Syndrome

Cited by 7 publications

References 36 publications

Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial

Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial

Use of CPAP in patients with obstructive sleep apnea admitted to the general ward: effect on length of stay and readmission rate

Beyond heart health: Consequences of obstructive sleep apnea

Contact Info

Product

Resources

About