Effect of short-term fluctuations in outdoor air pollution on the number of hospital admissions due to acute myocardial infarction among inhabitants of Krakow, Poland

Konduracka, Ewa; Niewiara, Łukasz; Guzik, Bartosz; Kotynia, Maksymilian; Szolc, Piotr; Gajos, Grzegorz; Nessler, Jadwiga; Podolec, Piotr; Żmudka, Krzysztof

doi:10.20452/pamw.4424

Cited by 21 publications

(16 citation statements)

References 23 publications

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“…Dysfunction of coronary microcirculation is associated with increased risk of major adverse cardiovascular events including cardiac death, stroke, and heart failure [6,7]. Chronic inflammation is considered as an important factor in pathophysiology of atherosclerosis [8][9][10]. Elevated level of inflammatory markers is observed in disease of epicardial arteries [11,12].…”

Section: Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio As Predictors Of Coronary Microcirculatory Disease Occurrence And Outcmentioning

confidence: 99%

Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio as Predictors of Coronary Microcirculatory Disease Occurrence and Outcome in Patients With Chronic Coronary Syndrome and No Significant Coronary Artery Stenosis

et al. 2020

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Introduction: Index of microcirculatory resistance assessment is an invasive method of measuring coronary microcirculation function. Association between impaired microcirculatory function and higher rate of cardiovascular events was proven. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio seem to be a promising parameters to predict coronary microcirculatory disease in patients with chronic coronary syndrome. The aim: To determine neutrophil-lymphocyte ratio and platelet-lymphocyte ratio levels in patients with coronary microcirculatory disease and potential association with clinical outcome. Material and methods: 82 consecutive patients with mean age of 67 years, 67% male, were tested for presence of coronary microcirculatory disease using index of microcirculatory resistance. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio were calculated based on admission full blood count. Follow-up with major adverse cardiac and cardiovascular events registration was performed (median 24 months). Results: The study showed significantly higher neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients with coronary microcirculatory disease compared to control group (3.58±2.61 vs 2.54±1.09 and 164±87.9 vs 124±36.6 respectively). Higher level of platelet-lymphocyte ratio in patients with coronary microcirculatory disease results in worse MACCE-free survival. Optimal cut-off values of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio to detect coronary microcirculatory disease were 3.2 and 181.3, respectively. Conclusions: Higher neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are associated with increased index of microcirculatory resistance value. Platelet-lymphocyte ratio may be used as a predictor of worse outcome in patients with coronary microcirculatory disease.

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Section: Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio As Predictors Of Coronary Microcirculatory Disease Occurrence And Outcmentioning

confidence: 99%

Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio as Predictors of Coronary Microcirculatory Disease Occurrence and Outcome in Patients With Chronic Coronary Syndrome and No Significant Coronary Artery Stenosis

et al. 2020

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“…e modelling results indicate that air pollution causes 2800 deaths a year in Warsaw [32]. Moreover, in epidemiological studies conducted in Cracow by Konduracka et al a correlation was found between air pollution with PM 2.5 and the incidence of myocardial infarction [33].…”

Section: Discussionmentioning

confidence: 95%

Gaseous Pollutants and Particulate Matter (PM) in Ambient Air and the Number of New Cases of Type 1 Diabetes in Children and Adolescents in the Pomeranian Voivodeship, Poland

Michalska

Zorena

Wąż

et al. 2020

BioMed Research International

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The increase in type 1 diabetes mellitus (T1DM) incidence in children is worrying and not yet fully explored. It is suggested that probably air pollution exposure could contribute to the development of T1DM. The aim of the study was to investigate the relationship between the concentration of gaseous pollutants including, nitrogen dioxide (NO2), nitric oxides (NOx), sulphur dioxide (SO2), carbon monoxide (CO), and particulate matter (PM) in the air, and the number of new cases of T1DM in children. The number of new cases of T1DM was obtained from the Clinic of Paediatrics, Diabetology, and Endocrinology, Medical University of Gdańsk. The number of children of 0–18 years old in Pomeranian Voivodeship was acquired from the Statistical Yearbook. The concentrations of PM10 absorbance, NO2, NOx, SO2, and CO were measured at 41 measuring posts, between 1 January 2015 and 31 December 2016. It was detected that the average annual concentration of PM10 was higher than the value acceptable to the WHO. Furthermore, the average 24-hour concentration of PM10 was 92 μg/m3 and was higher compared to the acceptable value of 50 μg/m3 (acc. to EU and WHO). Moreover, the number of new cases of T1DM showed a correlation with the annual average concentration of PM10 (β = 2.396, p<0.001), SO2 (β = 2.294, p<0.001), and CO (β = 2.452, p<0.001). High exposure to gaseous pollutants and particulate matter in ambient air may be one of the factors contributing to the risk of developing T1DM in children. Therefore, it is important to take action to decrease air pollutant emissions in Poland. It is crucial to gradually but consistently eliminate the use of solid fuels, such as coal and wood in households, in favour of natural gas and electricity. The development of new technologies to improve air quality, such as “best available techniques” (BAT) or renewable energy sources (water, wind, and solar generation) is of critical importance as well.

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“…Time-series analyses of PM-related morbidity in Poland are still rare and, to the authors' knowledge, until the end of 2021, no paper was published that included an analysis of the risk of hospitalizations with the use of GAM models. Several studies have applied other time-series methods to calculate air-pollution-related morbidity risks in individual cities [37][38][39], single voivodeships [40] or several selected locations [41][42][43][44][45], but none of them included a multi-city meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Ambient Particulate Air Pollution and Daily Hospital Admissions in 31 Cities in Poland

Adamkiewicz¹,

Maciejewska

Rabczenko

et al. 2022

Atmosphere

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A strong and consistent association has been observed between morbidity or mortality rates and PM concentration, and is well documented in many countries. In Poland, despite poor air quality, studies concerning the evaluation of acute health effects of ambient air pollution on morbidity from respiratory or cardiovascular diseases are rare. We examined the short-term impact of PMx concentration on hospital admission in 31 Polish cities based on the daily PM10, PM2.5 concentration, meteorological variables, and hospital data. The generalized additive model (GAM) and a random-effects meta-analysis were used to assess the impact of air pollution on morbidity within the exposed population. Almost 1.6 million cardiovascular admissions and 600 thousand respiratory disorders were analyzed. The RR values for PM10-related cardiovascular and respiratory hospital admissions in Poland are equal to 1.0077 (95% confidence interval, 1.0062 to 1.0092) and 1.0218 (95% confidence interval, 1.0182 to 1.0253), respectively, while for PM2.5 1.0088 (95% confidence interval, 1.0072 to 1.0103) and 1.0289 (95% confidence interval, 1.0244 to 1.0335), respectively. Moreover, a moderate heterogeneity of RR estimates was observed between the analyzed cities (I2 values from 27% to 45%). The presented analysis confirms the significant association between hospital admission and PMx concentration, especially during heating seasons.

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Effect of short-term fluctuations in outdoor air pollution on the number of hospital admissions due to acute myocardial infarction among inhabitants of Krakow, Poland

Cited by 21 publications

References 23 publications

Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio as Predictors of Coronary Microcirculatory Disease Occurrence and Outcome in Patients With Chronic Coronary Syndrome and No Significant Coronary Artery Stenosis

Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio as Predictors of Coronary Microcirculatory Disease Occurrence and Outcome in Patients With Chronic Coronary Syndrome and No Significant Coronary Artery Stenosis

Gaseous Pollutants and Particulate Matter (PM) in Ambient Air and the Number of New Cases of Type 1 Diabetes in Children and Adolescents in the Pomeranian Voivodeship, Poland

Ambient Particulate Air Pollution and Daily Hospital Admissions in 31 Cities in Poland

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