Effect of short-term intensive insulin therapy on α-cell function in patients with newly diagnosed type 2 diabetes

Abstract

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Repair of damaged pancreatic β cells: New hope for a type 2 diabetes reversal?

“…[6] Shortterm intensive insulin therapy can improve the pathophysiological defects underlying T2DM (insulin resistance, pancreatic β-cell dysfunction, and α-cell dysfunction). [5,7] Taylor et al [8] have shown that T2DM is a condition mainly caused by excessive, yet reversible, fat accumulation in the liver and pancreas, and reversal of T2DM requires a reduction in fat content in the liver and pancreas. The Diabetes Remission Clinical Trial (DiRECT) demonstrated that the ability of β cells in recovering their long-term function persists after diagnosis, changing the previous paradigm of irreversible loss of β-cell function in T2DM.…”