Effect of Short-Term Interval Exercise Training on Fatigue, Depression, and Fitness in Normal Weight vs. Overweight Person With Multiple Sclerosis

Negaresh, Raoof; Motl, Robert W.; Mokhtarzade, Motahare; Ranjbar, R; Majdinasab, Nastaran; Khodadoost, Mostafa; Zimmer, Philipp; Baker, Julien S.; Patel, Darpan I.

doi:10.1016/j.explore.2018.07.007

Cited by 25 publications

(45 citation statements)

References 41 publications

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“…1. Eighteen studies (34.6%) involved only aerobic exercises [5,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45], 16 studies (30.8%) involved only resistance exercise [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61], and 18 studies (34.6%) involved a combination of aerobic and resistance exercise [62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77]…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

et al. 2021

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Introduction: The objective of this systematic review is to explore the application and reporting of (i) the principles of exercise training in exercise trials, (ii) the components of exercise prescription, and (iii) the adherence towards the prescribed programmes in randomised controlled trials (RCTs) in persons with multiple sclerosis (pwMS). Methods:The MEDLINE, CINAHL, SPORTDiscus, PubMed and Embase electronic databases were searched from 1 January 2000 to 16 October 2020. RCTs comprising at least 3 weeks of aerobic and/or resistance exercise intervention in pwMS that reported at least one physiological outcome and were published in peerreviewed journals were eligible for inclusion. Results: Out of 52 RCTs included in this review, 58 intervention arms were examined. None applied more than four principles of exercise training. Specificity was addressed by 85%, progression by 33%, overload by 59%, initial values by 26%, reversibility by 0% and diminishing returns by 2% of trials. Fifty-two percent of trials reported all components of exercise prescription, and 3% of trials reported the level of adherence to the prescribed exercise. Marit L. Schlagheck and Niklas Joisten contributed equally and share first authorship. Annette Rademacher and Philipp Zimmer contributed equally and share last authorship.

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Section: Resultsmentioning

confidence: 99%

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

et al. 2021

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“…However, whether related to the factor being considered, the intervention, and/or the outcome of interest, baseline status may not influence responsiveness. One study that compared the effect of short-term interval exercise training on fatigue, depression, and fitness between normal-weight and overweight persons with MS reported no significant relationship for weight status interactions for any outcome, suggesting that exercise was effective independent of baseline weight status in persons with MS. 73…”

Section: Factors Contributing To Response Heterogeneitymentioning

confidence: 99%

Response Heterogeneity With Exercise Training and Physical Activity Interventions Among Persons With Multiple Sclerosis

Baird

Motl

2018

Neurorehabil Neural Repair

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Multiple sclerosis (MS) is a heterogeneous disease, both in its pathology and symptomology. This poses a challenge for the medical management and rehabilitation of MS; however, physical activity and exercise training are rehabilitation approaches that have demonstrated beneficial effects on many of the burdensome consequences of MS such as mobility impairment and fatigue. Given the heterogeneous course of MS, it is possible that outcomes of physical activity and exercise training interventions demonstrate heterogeneity both in the magnitude and pattern of change, but there has been little focus on response heterogeneity with these interventions among persons with MS. In this narrative review, a search of the existing literature was performed to identify studies that reported individual participant data, which was used to describe the variability in the response to physical activity and exercise training interventions among persons with MS. Inter-individual variability seemingly occurs across outcomes and modalities, which underscores the consideration of factors that might influence response heterogeneity. Factors related to MS disease characteristics, nervous system damage, and the degree of MS-related disability might influence individual responsiveness. Large-scale studies that permit the examination of heterogeneity and its predictors will inform future research on the area of physical activity and exercise training in MS, and lead to the development of individually tailored rehabilitation approaches that will more effectively elicit change.

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“…We reviewed reference lists of systematic reviews for includable literature, Technical Expert Panel members were asked to provide suggestions about unpublished literature and authors of studies were contacted for information (no additional information was provided). [5][6][7][8][9] Methods were consistent with those outlined in the Agency for Healthcare Research and Quality Evidence-based Practice Center Program Methods Guidance (https://effectivehealthcare.ahrq.gov/topics/cer-methods-guide/overview) and are detailed in the full report (in press to be available at https://effectivehealthcare.ahrq.gov/). The criteria for selection of studies to be included in the review were pre-established and used to determine eligibility for inclusion and exclusion of abstracts according to the EPC Methods Guide (Table 1).…”

Section: Methodsmentioning

confidence: 99%

“…20,21 Six studies found no clear benefit of cycling on walking in participants with MS compared with usual care, attention control, or waitlist control. 8,[22][23][24][25][26] One study in MS 9 and one in CP 27 together provided evidence that dance may improve function (mobility) when compared with usual care.…”

Section: Aerobic Interventions Included Aerobic Exercises Aquatics Cycling Robot-assisted Gait Training and Treadmill Training Individualmentioning

confidence: 99%

Physical Activity and the Health of Wheelchair Users: A Systematic Review in Multiple Sclerosis, Cerebral Palsy, and Spinal Cord Injury

Selph

Skelly

Wasson

et al. 2021

Archives of Physical Medicine and Rehabilitation

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Effect of Short-Term Interval Exercise Training on Fatigue, Depression, and Fitness in Normal Weight vs. Overweight Person With Multiple Sclerosis

Abstract: The results from this study confirm that exercise is an effective therapeutic intervention for improving fatigue, depression and functional parameters, independent of initial weight status, in persons with MS.

Cited by 25 publications

References 41 publications

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

Response Heterogeneity With Exercise Training and Physical Activity Interventions Among Persons With Multiple Sclerosis

Physical Activity and the Health of Wheelchair Users: A Systematic Review in Multiple Sclerosis, Cerebral Palsy, and Spinal Cord Injury

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