Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals

Denniss, Steven G; Häffner, Thomas; Kroetsch, Jeffrey T.; Davidson, Sara; Rush, James W. E.; Hughson, Richard L.

doi:10.2147/vhrm.2008.04.01.213

Cited by 33 publications

(43 citation statements)

References 53 publications

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“…In particular, lycopene has been accounted for cell growth regulation through apoptosis and cell cycle inhibition [50][51][52][53][54][55], facilitation of gap junction communication [56,57], stimulation of immune system [51,[58][59][60], modulation of endocrine-mediated pathways [57,58], induction of detoxifying enzymes [61,62] and reduction of cell surface adhesion and intima-media thickness [63]. Many studies have underlined how lycopene has anti-proliferative and prodifferentiation properties; in particular, it can inhibit proliferation of several types of cancer cells, including those of prostate, breast, lung, and endometrium [58,64,65].…”

Section: Lycopene: Chemistry Biochemical Func-tions Dietary Sourcesmentioning

confidence: 99%

“…Accordingly, Kawashina et al [221] showed that measures of oxidative stress decreased with a decline of serum lipid peroxides and of urine 8-OHdG. Dennis et al [63] instead found that a short-term supplementation did not affect either the plasma lipid-soluble antioxidant pool or the biomarkers of vascular oxidative stress and inflammation. More recently, a study on the supplementation with purified lycopene [224] confirmed that at high dose of 30 mg lycopene/day decreased DNA oxidative damage in lymphocytes and urinary 8-hydroxy-deoxyguanosine while no significant differences were observed for glucose, lipid profile and other biomarkers of lipid peroxidation.…”

Section: Interventional Studiesmentioning

confidence: 99%

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Lycopene and Cardiovascular Diseases: An Update

Mordente

Guantario²,

Meucci³

et al. 2011

CMC

146

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Cardiovascular disease (CVD) is the leading cause of death in Western societies and accounts for up to a third of all deaths worldwide. In comparison to the Northern European or other Western countries, the Mediterranean area has lower rates of mortality from cardiovascular diseases and cancer, and this is attributed, at least in part, to the so-called Mediterranean diet, which is rich in plantderived bioactive phytochemicals. Identification of the active constituents of the Mediterranean diet is therefore crucial to the formulation of appropriate dietary guidelines. Lycopene is a natural carotenoid found in tomato, an essential component of the Mediterranean diet, which, although belonging to the carotenoid family, does not have pro-vitamin A activity but many other biochemical functions as an antioxidant scavenger, hypolipaemic agent, inhibitor of pro-inflammatory and pro-thrombotic factors, thus potentially of benefit in CVD. In particular, the review intends to conduct a systematic analysis of the literature (epidemiological studies and interventional trials) in order to critically evaluate the association between lycopene (or tomato products) supplementation and cardiovascular diseases and/or cardiovascular disease risk factors progression, and to prepare provision of evidence-based guidelines for patients and clinicians. Several reports have appeared in support of the role of lycopene in the prevention of CVD, mostly based on epidemiological studies showing a dose-response relationship between lycopene and CVD. A less clear and more complex picture emerges from the interventional trials, where several works have reported conflicting results. Although many aspects of lycopene in vivo metabolism, functions and clinical indications remain to be clarified, supplementation of low doses of lycopene has been already suggested as a preventive measure for contrasting and ameliorating many aspects of CVD.

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Section: Lycopene: Chemistry Biochemical Func-tions Dietary Sourcesmentioning

confidence: 99%

Section: Interventional Studiesmentioning

confidence: 99%

Lycopene and Cardiovascular Diseases: An Update

Mordente

Guantario²,

Meucci³

et al. 2011

CMC

146

View full text Add to dashboard Cite

show abstract

“…Neste estudo, ficou evidente uma diminuição da integridade das membranas plasmática e do retículo sarcoplasmático após o exercício. Vários experimentos comprovaram a eficiência do licopeno: na redução significativa de tumores da próstata 22 , no risco de câncer pancreático 23 , prevenção de tumores de mama 24 , redução do tamanho da próstata em hiperplasias benignas 25 , redução no risco de desenvolvimento de doenças coronarianas 26 , no controle significativo de dislipidemias 27 e na redução da indução de crises asmáticas 28 . Experimentos mostraram a eficiência do antioxidante ácido ascór-bico como um potente suplemento que aumenta a sobrevida dos cardiomiócitos e promove a neovascularização cardíaca 29 .…”

Section: Discussionunclassified

Ação do licopeno nos músculos esquelético e cardíaco sob estresse oxidativo por exercícios

Simões

Magosso

Lagoeiro

et al. 2014

Rev Bras Med Esporte

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RESuMoIntrodução: Os radicais livres produzidos durante os exercícios podem exceder o sistema de defesa antioxidante, provocando danos oxidativos de biomoléculas específicas. As lesões causadas pelos radicais livres nas células podem ser prevenidas ou reduzidas por meio da atividade de antioxidantes naturais, sendo estes encontrados em muitos alimentos. O licopeno é um dos mais potentes carotenoides com ação antioxidante, sendo utilizado na prevenção da carcinogênese e aterogênese por proteger moléculas como lipídios, lipoproteínas de baixa densidade (LDL), proteínas e DNA. Objetivo: Investigar a atuação do licopeno a uma possível ação protetora das fibras musculares cardíacas e esqueléticas contra o estresse oxidativo, durante a atividade física exaustiva, a qual provocaria alterações morfológicas nesses tecidos. Método: Na realização dos experimentos foram utilizados 32 ratos machos adultos divididos em quatro grupos, sendo dois grupos controles e dois grupos treinados sem e com suplementação de licopeno (6 mg por animal). Os animais dos grupos treinados foram submetidos a 42 sessões de natação por nove semanas, com sessões diárias de natação, cinco dias por semana, com sobrecarga produzida pelo aumento do tempo de treinamento. A avaliação morfológica foi realizada por meio de lâminas histológicas dos tecidos cardíaco e muscular esquelético. Resultados: Modificações teciduais cardíacas e musculares esqueléticas no grupo treinado sem suplementação com licopeno foram observadas, sendo que o grupo treinado suplementado apresentou aspecto morfológico normal. Nos grupos sedentários controle suplementado e não suplementado não houve alteração em relação às características histológicas dos tecidos. Conclusão: Podemos afirmar que o licopeno exerceu um efeito protetor nos músculos cardíaco e esquelético contra o estresse oxidativo, induzido por exercícios exaustivos, além de promover uma neovascularização do tecido cardíaco, podendo ser utilizado com eficiência por atletas e praticantes de atividade física. Palavras

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“…Four weeks of lycopene supplementation (tomato-derived Lyc-O-Mato) at 30mg·day -1 in obese patients was not found to favorably influence markers of inflammation and oxidation biomarkers, despite a significant increase in plasma cartenoids, and specifically lyopene (Markovits et al, 2009). One week of lyopene supplementation (80mg·day -1 ) was found again to increased endogenous capacity of plasma lipid-soluble antioxidants (lycopene, -carotene, and -tocopherol); however, biomarkers of vascular oxidative stress and inflammation were unaffected in the fasted state, as well as post consumption of a high fat meal, in young, healthy subjects (Denniss et al, 2008). Finally, both acute (24 hour) and long-term (seven day) tomato puree consumption had no effects on endothelial dysfunction after consumption of a meal, despite a significant increase in plasma lyopene levels in healthy postmenopausal women (Stangl et al, 2011).…”

Section: Lycopenementioning

confidence: 95%