Many Indian women suffer from hypothyroidism. Thyroid imbalance, if left untreated, may lead to elevated cholesterol, excess body fat, hypertension, cardiovascular disease, an irregular heartbeat, and even depression. Hypothyroidism is more common in India (11% prevalence) than in the United Kingdom (2%) and the United States (4-6%). The incidence of hypothyroidism is 13% higher in women aged 35-60 than in any other age group. Weight loss, dyslipidemia, depression, cardiovascular and respiratory difficulties, and autonomic nervous system balance are only few of the benefits of yoga. In this study we investigated whether middle-aged women with hypothyroidism would have different results for certain physiological variables such as body mass index and heart rate. The effects of yoga on body mass index and heart rate in middle-aged women (35-60 years old) with hypothyroidism were the subject of a randomized controlled trial. Thirty middle-aged women were recruited for the research, with 15 placed in a Yoga group and 15 in a control group, all for 8-week intervention period. Body mass index (BMI) and heart rate (HR) were measured before and after the training session for both Experimental group I and Control group II. The analysis of covariance (ANCOVA) was performed to identify group-specific differences. The significance threshold of the test was set at 0.05. In this study, Yoga significantly affect physiological variables in middle-aged women with hypothyroidism. Middle-aged women with hypothyroidism might benefit from practicing yoga to lower their body mass index and heart rate.