Effect of short-term propionate infusion on feed intake and blood parameters in sheep

Leuvenink, H; Bleumer, E.J.B.; Bongers, L.J.G.M.; Bruchem, J. van; Heide, D. van der

doi:10.1152/ajpendo.1997.272.6.e997

Cited by 16 publications

(13 citation statements)

References 3 publications

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“…Simultaneously, the arterial concentrations of L-lactate, propanol, and propionate increased, which also might decrease glucose uptake in peripheral tissues. Furthermore, we cannot exclude the possibility that the marked response of plasma propionate to PG infusion could be involved in the hyperinsulinemic effect of PG (Sano et al, 1993;Leuvenink et al, 1997).…”

Section: Glucose Metabolismmentioning

confidence: 99%

Ruminal and Intermediary Metabolism of Propylene Glycol in Lactating Holstein Cows

Kristensen

Raun

2007

Journal of Dairy Science

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Four lactating Holstein cows fitted with ruminal cannulas and permanent indwelling catheters in the mesenteric artery, mesenteric vein, hepatic portal vein, and hepatic vein were used in a cross-over design to study the metabolism of propylene glycol (PG). Each cow received 2 treatments: control (no infusion) and infusion of 650 g of PG into the rumen at the time of the morning feeding. Propylene glycol was infused on the day of sampling only. Samples of arterial, portal, and hepatic blood as well as ruminal fluid were obtained at 0.5 h before feeding and at 0.5, 1.5, 2.5, 3.5, 5, 7, 9, and 11 h after feeding. Infusion of PG did not affect ruminal pH or the total concentration of ruminal volatile fatty acids, but did decrease the molar proportion of ruminal acetate. The ruminal concentrations of PG, propanol, and propanal as well as the molar proportion of propionate increased with PG infusion. The plasma concentrations of PG, ethanol, propanol, propanal, glucose, L-lactate, propionate, and insulin increased with PG and the plasma concentrations of acetate and beta-hydroxybutyrate decreased. The net portal flux of PG, propanol, and propanal increased with PG. The hepatic uptake of PG was equivalent to 19% of the intraruminal dose. When cows were dosed with PG, the hepatic extraction of PG was between 0 and 10% depending on the plasma concentration of PG, explaining the slow decrease in arterial PG. The increased net hepatic flux of L-lactate with PG could account for the entire hepatic uptake of PG, which suggests that the primary hepatic pathway for PG is oxidation to l-lactate. The hepatic uptake of propanol increased with PG, but no effects of PG on the net hepatic and net splanchnic flux of glucose were observed. Despite no effect of PG on net portal flux and net hepatic flux of propionate, the net splanchnic flux of propionate increased and the data suggest that propionate produced from hepatic metabolism of propanol is partly released to the blood. The data suggest that PG affects metabolism of the cows by 2 modes of action: 1) increased supply of l-lactate and propionate to gluconeogenesis and 2) insulin resistance of peripheral tissues induced by increased concentrations of PG and propanol as well as a decreased ratio of ketogenic to glucogenic metabolites in arterial blood plasma.

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Section: Glucose Metabolismmentioning

confidence: 99%

Ruminal and Intermediary Metabolism of Propylene Glycol in Lactating Holstein Cows

Kristensen

Raun

2007

Journal of Dairy Science

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“…Plasma insulin concentrations were quantified in duplicate with a validated RIA (Leuvenink et al, 1997). The sensitivity was 7.3 IU/mL at 80% of the maximal binding.…”

Section: Plasma Analysesmentioning

confidence: 99%

Dietary energy source at two feeding levels during lactation of primiparous sows: I. Effects on glucose, insulin, and luteinizing hormone and on follicle development, weaning-to-estrus interval, and ovulation rate.

Brand

Dieleman

Soede

et al. 2000

Journal of Animal Science

103

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Our objective was to study the effects of dietary-induced insulin enhancement during and after lactation on the reproductive performance of primiparous sows. During a 21-d lactation period, 48 sows were allotted to a 2 × 2 factorial experiment. Treatments were feeding level (high or low; 44 MJ or 33 MJ NE/d) and dietary energy source (fat or starch). After weaning, all sows received the same amount of feed (31 MJ NE/d from weaning to estrus and 17.5 MJ NE/d from breeding until slaughter) of the same energy source as fed during lactation. On d 7, 14, and 21 of lactation and d 22 (weaning), blood samples were taken every 12 min for 12 h and analyzed for plasma glucose, insulin, and LH. Sows were slaughtered on d 35 of the subsequent pregnancy, and ovulation rate was assessed. During lactation, postprandial plasma glucose and insulin concentrations were higher for sows fed the starch diet than for those fed the fat diet (P < .001), whereas feeding level had no effect. Basal and mean LH concentrations were not affected by treatments. The LH pulse fre-

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“…Of the volatile fatty acids produced, propionate is the most important for gluconeogenesis and, as a result, increasing the yield of propionate has been proposed as a strategy to improve feed efficiency (Rogers and Davis 1982;Leuvenink et al 1997) and marbling in meat (Sano et al 1993;Kersten 2001). Volatile fatty acid profiles have been shown to influence not only the extent of lipogenesis, but also the site (Smith and Crouse 1984).…”

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confidence: 99%

Effect of Propionibacterium acidipropionici P169 on growth performance and rumen metabolism of beef cattle fed a corn- and corn dried distillers’ grains with solubles-based finishing diet

et al. 2014

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Narvaez, N., Alazzeh, A. Y., Wang, Y. and McAllister, T. A. 2014. Effect of Propionibacterium acidipropionici P169 on growth performance and rumen metabolism of beef cattle fed a corn- and corn dried distillers’ grains with solubles-based finishing diet. Can. J. Anim. Sci. 94: 363–369. A growth and metabolism experiment was conducted to evaluate the effect of Propionibacterium acidipropionici P169 on feedlot steers fed a corn- and corn dried distillers' grains with soluble (DDGS)-based finishing diet. Steers (40 non-cannulated and 8 ruminally cannulated) were divided into two groups and administered 10 g head−1 d−1 of maltodextrin containing 1×1011 colony-forming units (CFU) of P169 or the same amount of carrier (Control), top-dressed once daily upon feeding. Feed intake, growth rate and feed efficiency were determined over 115 d. For cannulated steers, ruminal pH was monitored continuously for 5 d during the second week of each month over the entire feeding period with rumen samples collected 3 h after feeding on days 1 and 5. Molar proportions of butyrate, branched-chain volatile fatty acids (VFA) and NH3-N concentration increased (P<0.01) with P169, whereas total VFA, molar proportions of propionate, the acetate:propionate ratio, and lactate concentration did not differ (P>0.05) between treatments. P169 had a limited effect on ruminal pH as duration and area under the curve both at pH 5.5 and 5.2 as well as frequency of acute ruminal acidosis bouts were similar (P>0.05) for both groups. Compared with control steers, steers fed P169 had more (P<0.05) bouts of subacute ruminal acidosis (SARA). All steers had similar (P>0.05) feed intake, growth rate, feed efficiency and carcass characteristics, except for longissiumus muscle area, being less (P<0.05) for P169 steers than controls. Supplementing P169 to beef cattle fed a corn- and corn DDGS-based finishing diet had no effect on growth performance of beef cattle or ruminal pH and increased the bouts of SARA.

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Effect of short-term propionate infusion on feed intake and blood parameters in sheep

Cited by 16 publications

References 3 publications

Ruminal and Intermediary Metabolism of Propylene Glycol in Lactating Holstein Cows

Ruminal and Intermediary Metabolism of Propylene Glycol in Lactating Holstein Cows

Dietary energy source at two feeding levels during lactation of primiparous sows: I. Effects on glucose, insulin, and luteinizing hormone and on follicle development, weaning-to-estrus interval, and ovulation rate.

Effect of Propionibacterium acidipropionici P169 on growth performance and rumen metabolism of beef cattle fed a corn- and corn dried distillers’ grains with solubles-based finishing diet

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