2012
DOI: 10.6000/1927-5951.2012.02.02.8
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Effect of Short Term Sibutramine Supplementation on Appetite Suppression and Related Metabolic Responses

Abstract: The appetite suppressing property of Sibutramine is well reported. The present study was undertaken to investigate the appetite regulatory mechanism and associated metabolic changes induced in male Sprague Dawley rats by its short term supplementation. The effect of the drug on the regulatory hormones and biochemical variables was studied at an oral dose of 10 mg/kg body weight. There was a decrease in food intake of rats by 35.5% in comparison to their basal food intake as well as untreated controls. There wa… Show more

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