Effect of short‐term treatment with bumetanide, quinapril and low‐sodium diet on dogs with moderate congestive heart failure

Ma, Martinez-Alcaine; Ynaraja, E.; Corbera, Juan Alberto; Ja, Montoya

doi:10.1111/j.1751-0813.2001.tb10709.x

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…32 Enalapril is commonly used, and a few studies have investigated the effect of quinapril in dogs and found a well-tolerated and effective dos- age. 33,34 As expected, both treatments reduced serum ACE activity in the dogs. Quinapril decreased ACE activity significantly more than did enalapril.…”

Section: Discussionmentioning

confidence: 99%

Neurohormonal and Circulatory Effects of Short-Term Treatment with Enalapril and Quinapril in Dogs with Asymptomatic Mitral Regurgitation

Moesgaard¹,

Pedersen²,

Teerlink

et al. 2005

Journal of Veterinary Internal Medicine

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The aim of the study was to compare the effect of 2 angiotensin-converting enzyme (ACE) inhibitors on neurohormonal and circulatory variables in Cavalier King Charles Spaniels (CKCSs) with asymptomatic mitral regurgitation (MR). Ten CKCSs with mild to severe untreated MR were treated with 2 ACE inhibitors, quinapril and enalapril (each at 0.5 mg/kg PO q24h for 7 days), in a double-blind, crossover study with a washout period of 7 days between treatments. Blood samples were drawn and echocardiography was performed on days 0, 7, 14, and 21. Both treatments reduced ACE activity (P < .001) and increased renin activity (P < .001) and atrial natriuretic peptide concentration (P < .005). The ACE inhibitors had no effect on the concentrations of nitrate and nitrite (NOx) or asymmetric dimethylarginine (ADMA). On day 0, a lower NOx concentration (P = .02) was found in samples taken in the clinic as compared to samples taken in the homes of the dogs. Quinapril caused a significant reduction in more variables that reflect the severity of MR (eg, jet size and left ventricular end diastolic diameter) than did enalapril. However, in terms of specific variables, no significant difference was identified between the effects of the 2 treatments on MR. These results suggest that ACE inhibitors do not affect NOx and ADMA concentrations in asymptomatic dogs, but exercise, stress, or some combination may influence NOx concentrations in these dogs.

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Section: Discussionmentioning

confidence: 99%

Neurohormonal and Circulatory Effects of Short-Term Treatment with Enalapril and Quinapril in Dogs with Asymptomatic Mitral Regurgitation

Moesgaard¹,

Pedersen²,

Teerlink

et al. 2005

Journal of Veterinary Internal Medicine

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“…In human beings and small animals, ACE inhibitors are usually used for long‐term application (Schon et al., 1994). But a beneficial effect on left ventricular performance in chronic mitral regurgitation could also be seen after a single dose of quinapril in man (Schon et al., 1994) and after short‐term treatment (4 weeks) in dogs (Martinez‐Alcaine et al., 2001). In our study, we used quinapril for 8 weeks and we could also observe significant beneficial effects on systolic cardiac variables as an increased stroke volume and cardiac output.…”

Section: Discussionmentioning

confidence: 99%

“…Results of human studies show that the proportion of patients reporting associated adverse effects, caused by generalized vasodilatation, was lower with quinapril than with captopril or enalapril (Frank et al., 1990). In small animal internal medicine, different ACE inhibitors are successful in treating different cardiovascular disorders, such as CHF and mitral valve insufficiency (Morisse and Kersten, 1995; Martinez‐Alcaine et al., 2001), but there are no studies or literature about the use and effects of ACE inhibitors in horses with mitral valve insufficiencies. Mitral valve insufficiency is the most common cardiovascular disease in horses (Reef et al., 1998) and can lead to exercise intolerance and resulting in acute congestive heart failure.…”

Section: Introductionmentioning

confidence: 99%

Effects of the ACE Inhibitor Quinapril on Echocardiographic Variables in Horses with Mitral Valve Insufficiency

Gehlen¹,

Vieht²,

Štádler³

2003

Journal of Veterinary Medicine Series A

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Twenty horses with mitral valve insufficiency, but without signs of congestive heart failure, and five horses without signs of heart disease were examined before and after medication with an angiotensin-converting enzyme (ACE) inhibitor. The examination included echocardiography assessment as well as heart catheterization. The echocardiographic examination included B-mode, M-mode, conventional and colour Doppler techniques. For 8 weeks, all horses were treated with Accupro 20 (active substance: Quinapril) at an oral dose rate of 120 mg/horse/day. A follow-up of the horses with mitral valve insufficiency after 8 weeks revealed a statistically significant increase in the stroke volume and the cardiac output as well as a decrease in regurgitation velocity time integral (VTI). The regurgitation blood velocity remained the same. The severity of mitral valve insufficiencies revealed a moderate improvement in five horses, from moderate to mild, after therapy. Significant changes of cardiac dimension (B-mode) and shortening fraction (M-mode) before and after treatment could not be observed. The owners' judgement of the horses' performance was that of a minor improvement. In the horses without clinical findings the results of examination before and after treatment remained the same.

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“…Several studies carried out with ACE1 in veterinary medicine demonstrate the capacity of these drugs to improve, even reverse, lung oedema because of their venous vasodilator and diuretic effects (Kittleson, 2000;Martinez-Alcaine et al, 2001). Similarly 14 dogs had vena cava distension before treatment and only 6 after treatment.…”

Section: Resultsmentioning

confidence: 99%

Effect of Treatment with Enalapril, Frusemide and a Low-sodium Diet on Dogs with Mitral Regurgitation

Ynaraja¹,

Caro²,

Montoya

2002

Journal of Applied Animal Research

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Abst rac tYnaraja, E., Caro, A. and Montoya, J.A. 2002. Effect of treatment with enalapril, frusemide a n d a low-sodium d i e t o n dogs w i t h m i t r a l regurgitation. J. Appl. Anim. Res., 22: 219-224.Thirty-five dogs with coiigestive heart failure due to chronic initral valve disease were treated with fruseinide (1 ing/kg bid), enalapril (0.4 ing/kg bid) and a low-sodium diet to evaluated the effects produced by coinbiiiatioii of these drugs and to ascertain the possible iiegative effects following the use of these drugs. The treatment was safe, effective and well tolerated. No major side effects and no significant changes i n haeinatological and biochemical variables were observed.

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Effect of short‐term treatment with bumetanide, quinapril and low‐sodium diet on dogs with moderate congestive heart failure

Cited by 9 publications

References 21 publications

Neurohormonal and Circulatory Effects of Short-Term Treatment with Enalapril and Quinapril in Dogs with Asymptomatic Mitral Regurgitation

Neurohormonal and Circulatory Effects of Short-Term Treatment with Enalapril and Quinapril in Dogs with Asymptomatic Mitral Regurgitation

Effects of the ACE Inhibitor Quinapril on Echocardiographic Variables in Horses with Mitral Valve Insufficiency

Effect of Treatment with Enalapril, Frusemide and a Low-sodium Diet on Dogs with Mitral Regurgitation

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