Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction

Cavalcanti, Ana Lucia; Bagnoli, Vicente Renato; Fonseca, Ângela Maggio da; Pastore, Roberto A.; Cardoso, Eduardo Blanco; Paixão, Jucilene Sales da; Soares, José Maria; Saad, F.; Baracat, Edmund C.

doi:10.1016/j.ijgo.2008.03.020

Cited by 37 publications

(34 citation statements)

References 16 publications

(24 reference statements)

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“…Outcome data from randomized trials in the general population on treatment of sexual dysfunction in women are unconvincing because they rely on surrogate outcomes, such as genital engorgement, changes in sexual function scores, and changes in female sexual function after treatment of their male partner (33)(34)(35)(36). The clinical relevance of such outcomes to women is not clear.…”

Section: Discussionmentioning

confidence: 99%

Sexual Dysfunction in Women with ESRD Requiring Hemodialysis

Strippoli

Depression

2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives The few existing studies of sexual dysfunction in women on hemodialysis are limited by small sample size. This large, cross-sectional study evaluated the prevalence and correlates of female sexual dysfunction in advanced kidney disease.Design, setting, participants, & methods A total of 1472 women with ESRD undergoing hemodialysis were recruited to a multinational, cross-sectional study conducted within a collaborative dialysis network in Europe and South America. Sexual dysfunction was identified by the Female Sexual Function Index. Correlates of selfreported sexual dysfunction were identified by regression analyses.Results Of the 1472 women, 659 completed questionnaires (45% Conclusions This descriptive study suggests most women on hemodialysis experience sexual problems. Additional research on the relevance of sexual dysfunction to symptom burden and quality of life in these women is needed.

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Section: Discussionmentioning

confidence: 99%

Sexual Dysfunction in Women with ESRD Requiring Hemodialysis

Strippoli

Depression

2012

Clinical Journal of the American Society of Nephrology

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“…This fact might explain the improvement in menopausal symptoms obser ved in both groups during the study. Fur thermore, our group expected that any improvement in vasomotor symptoms would have an impact on sexuality, and for this reason we applied the GRISS 28 . This questionnaire has been validated in Brazil 28 and other countries to assess the presence and severity of sexual problems.…”

Section: Discussionmentioning

confidence: 99%

“…Subjective evaluation of the sexuality of sexually active women was per formed using the GRISS 27 , a reproducible questionnaire already validated in Brazil 28 . This inventor y consists of a questionnaire with 28 questions that evaluate how women relate to their own body and to their par tner 's, the level of interest in sexual activity, quality of communication with the par tner, sexual frequency, and the ability to achieve orgasm.…”

Section: Golombok R U S T I N V E N T O R Y O F S E X U a L S At I Sfmentioning

confidence: 99%

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Efeitos do Trifolium pratense nos sintomas climatéricos e sexuais na pós-menopausa

Giorno¹,

Fonseca²,

Bagnoli³

et al. 2010

Rev. Assoc. Med. Bras.

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objectIve. To evaluate the effects of treatment with Trifolium pratense on climacteric symptoms and sexual satisfaction in postmenopausal women. Methods. This is a prospective, randomized, double-blind, placebo-controlled study. Initially, 120 women aged 45-65 years with menopausal symptoms, more than 12-month amenorrhea and no treatment in the past six months were selected. The participants were then divided into two groups: TG -receiving 40 mg Trifolium pratense, 1 capsule/day; PG -receiving placebo capsules containing lactose (control), 1 capsule/day. The duration of treatment was 12 months. The patients underwent clinical and laboratory evaluation before treatment and at four, eight and 12 months of treatment. The Kupperman Menopausal Index and the Golombok Rust Inventory of Sexual Satisfaction (GRISS) were used. At the end of the study, each group comprised 50 patients. results. According to the Kupperman Menopausal Index, there was significant improvement in menopausal symptoms after four months of treatment, especially in relation to hot flashes, when compared to baseline data in both groups. However, no significant differences were observed between groups. There was no improvement in sexual satisfaction after treatment. conclusIon. A 12-month treatment with a daily dose of 40 mg Trifolium pratense did not yield a significant improvement in menopausal symptoms and sexual satisfaction.

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“…Therefore, improvement of the study subjects' sexual desire could have occurred due to the fact that they expected a positive change after using sildenafil. Another study also showed that, in comparison to the placebo, sildenafil was more effective in increasing clitoral blood flow [20].…”

Section: Resultsmentioning

confidence: 97%

Effect of sildenafil citrate on women affected by sexual dysfunction referred to health clinics

Zeinalzadeh

Akbarzadeh

Faridi

et al. 2017

fmpcr

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Background. Female sexual dysfunction is a serious, multifactorial problem which affects women's quality of life. Objectives. This study aimed at assessing the effect of sildenafil citrate on sexual dysfunction among women of reproductive age. Materials and methods. The present randomized clinical trial was conducted on 84 married women between 18 and 40 years old who suffered from sexual dysfunction. The inclusion criteria of the study were being married and between 18-40 years old, obtaining scores ≥ 22 in FSFI, not having a history of hypothyroidism or hyperprolactinemia, and not suffering from dyspareunia or vaginismus. The intervention group was required to consume 50 mg sildenafil citrate 1 hour before sexual intercourse for 5 weeks, and the control group received placebo. FSFI was completed by both study groups before and 5 weeks after the treatment. The data were analyzed through SPSS (v. 18) and paired t-test and independent t-test. Results. Most of the women (67.2%) were between 30 and 40 years old. The study results revealed a significant difference between the two groups regarding the mean scores of sexual desire (p = 0.011), sexual arousal (p = 0.001), lubrication (p = 0.026), orgasm and sexual satisfaction (p < 0.001), and the whole dimension (p < 0.001). Besides, total mean sexual function before and after for the intervention and control groups was 21.1 ± 3.28 vs. 17.22 ± 5.9 (p < 0.001). Conclusion. In this study, sildenafil citrate was effective in enhancing sexual desire, arousal, orgasm, and sexual satisfaction. Of course, more studies need to be conducted on this issue.

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Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction

Abstract: Sildenafil may improve clitoral blood flow and increase the GRISS scores in postmenopausal women with orgasmic dysfunction.

Cited by 37 publications

References 16 publications

Sexual Dysfunction in Women with ESRD Requiring Hemodialysis

Sexual Dysfunction in Women with ESRD Requiring Hemodialysis

Efeitos do Trifolium pratense nos sintomas climatéricos e sexuais na pós-menopausa

Effect of sildenafil citrate on women affected by sexual dysfunction referred to health clinics

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