Effect of Silica Exposure on Urinary Excretion of Copper and Zinc

Urinary Trace Elements Are Biomarkers for Early Detection of Acute Kidney Injury

“…Rodent models have revealed that Cu is present in PT cells 50 52 and is bound to MTs within PT epithelial cells. 53 Studies of renal tubular silica toxicity have revealed Cu release into the urine as a result of tubular toxicity, 54 but presence of Cu in the urine after ATI has not been reported. Zn is absorbed predominantly in the duodenum and jejunum.…”

Renal functional and structural integrity in infants with iron deficiency anemia: relation to oxidative stress and response to iron therapy

“…The presence of proximal tubular structural damage among our IDA patients, as evidenced by increased urinary excretion of LAP and the significant positive correlation between LAP and the level of each of urinary zinc and copper, supports this possibility. Urinary levels of copper and zinc have been found to be correlated with both glomerular and tubular functional and structural parameters [27]. Thus, it would appear that both mechanisms may operate simultaneously in IDA, leading to the increased urinary excretion of zinc and copper which could serve as reliable markers for glomerular and proximal tubular alterations.…”

Relationship between occupational exposure to respirable crystalline silica and serum copper level as an indicator of silicosis: A systematic review and meta-analysis

“…Several studies have reported a relationship between serum copper levels and silicosis. [ 12 13 14 ] Cu has a fibrogenic role in the primary pathologic changes of silicosis including fibrosis and the proliferation of collagen tissue in the lungs, which raises the possibility of an association between serum Cu levels and silicosis. [ 12 ] Due to inconsistent results regarding the relationship between serum copper levels and silicosis, the present study aimed to evaluate this association as a systematic review and meta-analysis.…”