“…As shown in Figure 2 (black line), the signal from the bare antennas (after plasma ozone cleaning) is almost flat with only some vibration peaks of the CaF 2 substrate appearing. 63 Much stronger signal is observed on antennas coated with the aptamer (Figure 2 64,66,67,73,77 The peaks positions agree with the literature on SERS of DNA and DNA bases, while the relative enhancement intensities of the single peaks turns out to be substrate-dependent (materials, shapes). 64,65,67,68,73 The surface blocking with 6-MHO (blue curve) does not shift the DNA vibrations, but neither provides new peaks to the spectrum but only yields some increase of the continuum background.…”