Effect of sılymarın on oxıdatıve stress and lıver hıstopathology ın experımental obstructıve jaundıce model

Abstract

PURPOSE:To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model. METHODS:Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1. Bile duct ligation was performed in group 2. In group 3, bile duct ligation was performed and orogastic silymarin 300 mg/ kg/day dose was given for seven days. At the end of seven days, rats were sacrificed. The blood and liver tissue samples were taken to be examined biochemically and histopathologically. RESULTS:The plasma and liver levels of malondialdehyde were significantly lower in silymarin group than in the bile duct ligated group. Although liver levels of GSH were significantly higher in silymarin group than in the bile duct ligated group, there was no significant difference between the plasma GSH levels of these groups. In silymarin group; the enlargement of hepatocytes, dilatation of canaliculi and the edema were regressed. CONCLUSION:Silymarin diminished the harmful effects of obstructive jaundice on liver.

Comparative Study on The Hepato-Protective Effect of Carvedilol and Nebivolol in Carbon Tetrachloride-Induced Liver Fibrosis in Normotensive and Hypertensive Albino Rats

“…In the present study, induction of liver fibrosis in Wistar male albino rats was done by injection with carbontetrachloride (CCl4) (2 ml/kg body weight, dissolved in olive oil [1:9(v/v)] by intraperitoneal (i.p) injection twice a week for 8 weeks (12) .…”

Artichoke for biochemistry, histology, and gene expression in obstructive jaundice

“…After the surgical procedures were completed, the rats were sacrificed on postoperative day 10, and liver tissue and blood samples were taken. The obstructive jaundice model in the study is a model that has been widely used by both our team members and other researchers [12][13][14] .…”

Molecular networking-assisted flavonoid profile of Gypsophila glomerata extract in relation to its protective effects on carbon tetrachloride-induced hepatorenal damage in rats

“…Freitag et al (46) reported that silymarin treatment has restored the hepatocyte functional and histopathological alterations induced by paracetamol in normotensive and hypertensive animals. In another study of experımental obstructıve jaundice model, the enlargement of hepatocytes, dilatation of canaliculi and the edema regressed in livers in the silymarin--treated group was reported (47).…”