2007
DOI: 10.1902/jop.2007.060480
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Effect of Simvastatin Administration on Periodontitis‐Associated Bone Loss in Ovariectomized Rats

Abstract: Within the limits of this study, it can be concluded that simvastatin shows protective features against the impact of periodontitis on attachment apparatus and alveolar bone.

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Cited by 45 publications
(53 citation statements)
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References 33 publications
(52 reference statements)
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“…This result is consistent with in vitro studies showing a decreased measure of osteoclastic potential (RANKL/osteoprotegrin mRNA) caused by simvastatin in mouse bone cell culture [27]. In a recent report, twice weekly injections of simvastatin appeared to reduce bone resorption in a ligature-induced rat periodontitis model [28]. However, in our studies, osteoclast surface was 4% of the total bone surface at 24 days, implying a remodeling process at that later time.…”
Section: Discussionsupporting
confidence: 92%
“…This result is consistent with in vitro studies showing a decreased measure of osteoclastic potential (RANKL/osteoprotegrin mRNA) caused by simvastatin in mouse bone cell culture [27]. In a recent report, twice weekly injections of simvastatin appeared to reduce bone resorption in a ligature-induced rat periodontitis model [28]. However, in our studies, osteoclast surface was 4% of the total bone surface at 24 days, implying a remodeling process at that later time.…”
Section: Discussionsupporting
confidence: 92%
“…One reason for the conflicting results may be that most statin preparations are given orally and are designed to be metabolized first by passage in the liver, in which the β‐hydroxy‐carboxyl metabolite is the active compound, inhibiting the 3‐hydroxy‐2‐methyl‐glutaryl coenzyme A reductase and inhibiting cholesterol synthesis. Only a small percentage of the statin passes through the liver and arrives at bone cells 47 . The current study has considered the technique of subgingivally delivering SMV directly into pockets of patients with type 2 diabetes and CP as the local drug delivery system offer the advantages of high concentrations at the target site with reduced dosage, fewer applications, and high patient acceptability 48 .…”
Section: Discussionmentioning
confidence: 99%
“…Based on this assumption, a possible beneficial role of statins in the management of periodontal inflammatory diseases has been proposed. However, the majority of the research has been conducted in vitro 30,31 or in animal models, 32‐34 mostly using topical administration of statins. Regarding the systemic consumption of statins by patients at risk for CVD, recent retrospective studies 35,36 have supported a positive role of statins for the periodontium.…”
mentioning
confidence: 99%