Effect of Simvastatin on the Prognosis and the Changes of the Clinical Status in Patients With Acute Ischemic Stroke. The Results of the 12 Month Randomized, Open Comparative Study

Yakusevich, V. V.; Malygin, A. Yu.; Kabanov, A. V.

doi:10.20996/1819-6446-2013-9-4-379-385

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…1). Of these 42 publications, 40 were in English, one was Russian 27 , and one Japanese 28 . In total, 40 RCTs reported about the effect of statins on change of eGFR 13–15,27,29–63 , of which 30 compared a statin to control, and 10 compared two or more statins with each other.…”

Section: Resultsmentioning

confidence: 99%

“…Of these 42 publications, 40 were in English, one was Russian 27 , and one Japanese 28 . In total, 40 RCTs reported about the effect of statins on change of eGFR 13–15,27,29–63 , of which 30 compared a statin to control, and 10 compared two or more statins with each other. The effect of statins on proteinuria was reported in 25 RCTs 13,14,28,29,32–34,36,39,45,46,48–54,57,60,62–65 , of which 19 compared a statin to control intervention, and six compared two or more statins.…”

Section: Resultsmentioning

confidence: 99%

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Effect of different types of statins on kidney function decline and proteinuria: a network meta-analysis

Esmeijer

Dekkers

Fijter

et al. 2019

Sci Rep

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Previous studies showed that statins reduce the progression of kidney function decline and proteinuria, but whether specific types of statins are more beneficial than others remains unclear. We performed a network meta-analysis of randomized controlled trials (RCT) to investigate which statin most effectively reduces kidney function decline and proteinuria. We searched MEDLINE, Embase, Web of Science, and the Cochrane database until July 13, 2018, and included 43 RCTs (>110,000 patients). We performed a pairwise random-effects meta-analysis and a network meta-analysis according to a frequentist approach. We assessed network inconsistency, publication bias, and estimated for each statin the probability of being the best treatment. Considerable heterogeneity was present among the included studies. In pairwise meta-analyses, 1-year use of statins versus control reduced kidney function decline by 0.61 (95%-CI: 0.27; 0.95) mL/min/1.73 m2 and proteinuria with a standardized mean difference of −0.58 (95%-CI:−0.88; −0.29). The network meta-analysis for the separate endpoints showed broad confidence intervals due to the small number available RCTs for each individual comparison. In conclusion, 1-year statin use versus control attenuated the progression of kidney function decline and proteinuria. Due to the imprecision of individual comparisons, results were inconclusive as to which statin performs best with regard to renal outcome.

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